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Open AccessArticle

Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose

1
Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, Napoli 80131, Italy
2
Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Via Cintia 21, Napoli 80126, Italy
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(8), 9420-9431; https://doi.org/10.3390/molecules18089420
Received: 27 May 2013 / Revised: 19 July 2013 / Accepted: 1 August 2013 / Published: 6 August 2013
(This article belongs to the Section Organic Chemistry)
The antiviral activity of certain acyclic nucleosides drew our attention to the fact that the replacement of the furanose ring by an alkyl group bearing hydroxyl(s) could be a useful structural modification to modulate the biological properties of those nucleosides. Herein, we report on the synthesis of some novel acadesine analogues, where the ribose moiety is mimicked by a d-ribityl or by a hydroxybutyl chain. View Full-Text
Keywords: AICAR; ZMP; acadesine; AMPK; AMPK activation; imidazole nucleosides; nucleoside analogues; modified nucleosides; acyclic nucleosides; acyclic nucleotides AICAR; ZMP; acadesine; AMPK; AMPK activation; imidazole nucleosides; nucleoside analogues; modified nucleosides; acyclic nucleosides; acyclic nucleotides
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MDPI and ACS Style

D'Errico, S.; Oliviero, G.; Borbone, N.; Amato, J.; Piccialli, V.; Varra, M.; Mayol, L.; Piccialli, G. Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose. Molecules 2013, 18, 9420-9431.

AMA Style

D'Errico S, Oliviero G, Borbone N, Amato J, Piccialli V, Varra M, Mayol L, Piccialli G. Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose. Molecules. 2013; 18(8):9420-9431.

Chicago/Turabian Style

D'Errico, Stefano; Oliviero, Giorgia; Borbone, Nicola; Amato, Jussara; Piccialli, Vincenzo; Varra, Michela; Mayol, Luciano; Piccialli, Gennaro. 2013. "Synthesis of New Acadesine (AICA-riboside) Analogues Having Acyclic d-Ribityl or 4-Hydroxybutyl Chains in Place of the Ribose" Molecules 18, no. 8: 9420-9431.

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