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Molecules 2013, 18(7), 8160-8167; https://doi.org/10.3390/molecules18078160

Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis

1,†
,
2,3,†
,
1,4,5
,
1
,
1,3,4
,
2,3,4
,
1,4,5,* and 1,2,3,4,6,7,*
1
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan
2
Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan
3
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
4
Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan
5
Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung 804, Taiwan
6
Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404, Taiwan
7
Graduate Institute of Natural Products, Kaohsiung Medical University, Kaohsiung 807, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Received: 27 May 2013 / Revised: 4 July 2013 / Accepted: 8 July 2013 / Published: 10 July 2013
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Abstract

A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinularia flexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells. View Full-Text
Keywords: flexibilisquinone; cultured soft coral; Sinularia flexibilis; anti-inflammatory; iNOS; COX-2 flexibilisquinone; cultured soft coral; Sinularia flexibilis; anti-inflammatory; iNOS; COX-2
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Lin, Y.-F.; Kuo, C.-Y.; Wen, Z.-H.; Lin, Y.-Y.; Wang, W.-H.; Su, J.-H.; Sheu, J.-H.; Sung, P.-J. Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis. Molecules 2013, 18, 8160-8167.

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