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Article

Herb-Drug Interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim Extract on the Pharmacokinetics of Sildenafil in Rats

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Institute of Traditional Medicine, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
2
Department of Urology, School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
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Department of Education and Research, Taipei City Hospital, Taipei 10341, Taiwan
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National Research Institute of Chinese Medicine, Taipei 11221, Taiwan
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Institute of Microbiology and Immunology, National Yang-Ming University, Taipei 11221, Taiwan
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Graduate Institute of Acupuncture Science, China Medical University, Taichung 40402, Taiwan
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(6), 7323-7335; https://doi.org/10.3390/molecules18067323
Received: 9 April 2013 / Revised: 16 May 2013 / Accepted: 19 June 2013 / Published: 21 June 2013
(This article belongs to the Section Natural Products Chemistry)
Epimedium sagittatum (Sieb. et Zucc.) Maxim is one of the herbs used to treat erectile dysfunction in Traditional Chinese Medicine. Sildenafil is a phosphodiesterase 5 inhibitor used to treat erectile dysfunction in Western Medicine. This study evaluates the herbal-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil in rats by ultra-performance liquid chromatography. The rat plasma was sampled from each anesthetized rat after pretreatment with 3-days Epimedium sagittatum extract (1/2 g/kg/day) and intravenous injection with sildenafil (10/30 mg/kg). The pharmacokinetic data demonstrate that the area under the concentration-time curve (AUC) of sildenafil (10 mg/kg) was significantly decreased in groups that received a high dose of Epimedium sagittatum extract. In conclusion, the study demonstrates that there was significant herb-drug interaction of Epimedium sagittatum extract on the pharmacokinetics of sildenafil at low and high daily doses, suggesting co-administration use of Epimedium sagittatum extract and sildenafil in clinical practice should be prevented due to possible herb-drug interactions. View Full-Text
Keywords: sildenafil; Epimedium sagittatum extract; herb-drug interaction; Traditional Chinese Medicine sildenafil; Epimedium sagittatum extract; herb-drug interaction; Traditional Chinese Medicine
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MDPI and ACS Style

Hsueh, T.Y.; Wu, Y.-T.; Lin, L.-C.; Chiu, A.W.; Lin, C.-H.; Tsai, T.-H. Herb-Drug Interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim Extract on the Pharmacokinetics of Sildenafil in Rats. Molecules 2013, 18, 7323-7335. https://doi.org/10.3390/molecules18067323

AMA Style

Hsueh TY, Wu Y-T, Lin L-C, Chiu AW, Lin C-H, Tsai T-H. Herb-Drug Interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim Extract on the Pharmacokinetics of Sildenafil in Rats. Molecules. 2013; 18(6):7323-7335. https://doi.org/10.3390/molecules18067323

Chicago/Turabian Style

Hsueh, Thomas Y., Yu-Tse Wu, Lie-Chwen Lin, Allen W. Chiu, Chi-Hung Lin, and Tung-Hu Tsai. 2013. "Herb-Drug Interaction of Epimedium sagittatum (Sieb. et Zucc.) Maxim Extract on the Pharmacokinetics of Sildenafil in Rats" Molecules 18, no. 6: 7323-7335. https://doi.org/10.3390/molecules18067323

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