Next Article in Journal
Phenolic Glucosides from Dendrobium aurantiacum var. denneanum and Their Bioactivities
Previous Article in Journal
Superoxide Scavenging Effects of Some Novel Bis-Ligands and Their Solvated Metal Complexes Prepared by the Reaction of Ligands with Aluminum, Copper and Lanthanum Ions
 
 
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

One-Pot Synthesis of Novel Chiral β-Amino Acid Derivatives by Enantioselective Mannich Reactions Catalyzed by Squaramide Cinchona Alkaloids

State Key Laboratory of Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang 550025, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2013, 18(6), 6142-6152; https://doi.org/10.3390/molecules18066142
Submission received: 1 April 2013 / Revised: 13 May 2013 / Accepted: 16 May 2013 / Published: 23 May 2013
(This article belongs to the Section Organic Chemistry)

Abstract

:
An efficient one-pot synthesis of novel β-amino acid derivatives containing a thiadiazole moiety was developed using a chiral squaramide cinchona alkaloid as organocatalyst. The reactions afforded chiral β-amino acid derivatives in moderate yields and with moderate to excellent enantioselectivities. The present study demonstrated for the first time the use of a Mannich reaction catalyzed by a chiral bifunctional organocatalyst for the one-pot synthesis of novel β-amino acid derivatives bearing a 1,3,4-thiadiazole moiety on nitrogen.

1. Introduction

β-Amino acids are key structural components of peptides, peptidomimetics, and natural products [1,2]. Stereochemically defined β-amino acids are synthesized and applied in drug development, molecular recognition, and bimolecular structure and functional studies [3,4,5,6,7]. Extensive research has been carried out to develop suitable methodology for the stereoselective synthesis of β-amino acids [8,9,10,11,12,13,14]. The general methods usually rely on classical resolution, stoichiometric use of chiral auxiliaries, or homologation of α-amino acids [15,16,17,18,19,20,21]. However, the synthesis of β-amino acids bearing various functional groups on the β-carbon, while maintaining desired chirality, is a big challenge. Thiadiazole ring systems have been well studied and reported to have a variety of biological activities, including antifungal, antitubercular, antibacterial, anticancer, and analgesic properties [22,23,24,25,26]. Therefore, enantio-enriched β-amino acids containing 1,3,4-thiadiazoles have potential therapeutic value and are a great challenge for chiral synthesis.
Our group has previously developed a highly enantioselective Mannich reaction catalyzed by cinchona alkaloid thiourea to produce novel β-amino acid ester and ketone derivatives containing benzoxazol and benzothiazole moieties, and β-amino ketones containing benzothiazole units [27,28,29]. In the present work, we report an enantioselective synthesis of β-amino acid derivatives bearing a 1, 3, 4-thiadiazole moiety on nitrogen by an asymmetric Mannich reaction catalyzed by a squaramide cinchona alkaloid catalyst. To the best of our knowledge, our study is the first one on the asymmetric synthesis of β-amino acid derivatives containing a 1,3,4-thiadiazole moiety on nitrogen in the presence of a squaramide organocatalyst.

2. Results and Discussion

2.1. Chemistry

In prior studies, several differentially substituted chiral derivatives of squaramides (SQ) have been synthesized and used as catalysts for asymmetric reactions [30,31,32,33,34]. The preparation of SQ involves an easy one-step synthesis as shown in Scheme 1. 3-(3,5-Bis(trifluoromethyl)phenylamino)-4-methoxycyclobut-3-ene-1,2-dione was stirred with 9-amino (9-deoxyquinine) in dry DCM at room temperature to produce the catalyst SQ in moderate yield.
Scheme 1. Synthesis of catalyst SQ.
Scheme 1. Synthesis of catalyst SQ.
Molecules 18 06142 g002
In search of the optimum catalyst for the enantioselective synthesis of β-amino acids containing 1,3,4-thiadiazoles, we initially tested two commercially available cinchona alkaloid catalysts Q-1 and Q-2 (Figure 1) in the catalytic one-pot asymmetric Mannich reaction of 2-amino-1,3,4-thiadiazole (1), benzaldehyde (2, R1 = Ph) and dimethyl malonate (3, R2 = Me) (Scheme 2).
Figure 1. Structures of commercial cinchona alkaloid catalysts.
Figure 1. Structures of commercial cinchona alkaloid catalysts.
Molecules 18 06142 g001
Scheme 2. Synthesis of the chiral β-amino acid derivatives.
Scheme 2. Synthesis of the chiral β-amino acid derivatives.
Molecules 18 06142 g003
The quinine catalyst Q-1 turned out to be a poor catalyst, affording a 37% yield and 11% ee, whereas the catalyst Q-2 performed slightly better, with 39% yield and 37% ee, respectively, when the reactions were carried out at 60 °C for 96 h (entry 1 and 2, Table 1). Since both Q-1 and Q-2 failed to achieve the desired high yield and enantioselectivity, we continued our search for a better catalyst and found that the cinchona alkaloid derivative (SQ) bearing both the hydrogen-bond donor squaramide and the hydrogen-bond acceptor tertiary amines delivered superior results. Compared with the quinine Q-1 and 9-amino (9-deoxyquinine) Q-2 catalysts, the SQ catalyst bearing strong electron-withdrawing trifluoromethyl substituents on its benzene ring achieved better yield (41%) and much higher enantioselectivity (91%) (entry 3, Table 1). The superior performance of SQ catalyst could be attributed to its ability to promote the reaction through double-hydrogen bond activation of the substrate.
Table 1. Screening of various catalysts a.
Table 1. Screening of various catalysts a.
Molecules 18 06142 i001
EntryCatalystTemp. (°C)SolventYield b (%)ee c (%)
1Q-1 60Toluene3711
2Q-2 60Toluene3937
3SQ 60Toluene4191
a Reactions were carried out with 1.0 mmol of 1, 1.2 mmol of 2, and 1.5 mmol of 3 in 3.0 mL of toluene in the presence of 10 mol% catalyst at 60 °C for 96 h. b Isolated yield after chromatographic purification. c ee Determined by HPLC analysis (Chiralpak IA).
The effects of three important experimental parameters (solvent, catalyst loading, and reaction temperature) on the SQ-catalyzed reactions were examined to determine the optimal reaction conditions (Table 2). We found that solvent significantly affected the reaction yield and ee of the final product. Among the four solvents tested, the best yield was obtained in methanol (53%) while the highest ee was achieved in toluene (91%). (entries 1–4, Table 2). The catalyst loading also affected the yield and ee of 4d. When the reaction was conducted at 60 °C in toluene, the highest yield (49%; entry 4, Table 2) and ee (91%; entry 4, Table 2) were obtained with the highest catalyst loading of 10 mol%. The yield and ee were also affected by the reaction temperature. When the reaction temperature was increased from room temperature to 60 °C, the reaction yield and ee increased by 12% and 11%, respectively (entries 4 and 5, Table 2). Taken together, the optimum result was achieved at 60 °C with 10 mol% catalyst loading in toluene.
Table 2. Optimization of reaction conditions using catalyst SQ a.
Table 2. Optimization of reaction conditions using catalyst SQ a.
Molecules 18 06142 i002
EntryCatalyst load (mol%)Temp. (°C)SolventYield b (%)ee c (%)
11060Methanol5371
21060Acetone4175
31060Chloroform3883
41060Toluene4991
510r.t.Toluene3780
6560Toluene4570
72.560Toluene4443
a Reactions were carried out with 1.0 mmol of 1, 1.2 mmol of 2, and 1.5 mmol of 3 in 2.0 mL of the specified solvent for 96 h. b Isolated yield after chromatographic purification. c ee Determined by HPLC analysis (Chiralpak IA).
Having established the ideal reaction conditions, we explored the synthetic scope of the reaction with different aldehydes and malonates as substrates. The results were summarized in Table 3. The highest enantioselectivities were obtained with a phenyl R1 group with higher than 45% yields (45% yield, 91% ee, entry 5; 52% yield, 99% ee, entry 6, Table 3). However, when the R1 group was substituted phenyl, the yields dropped below 45% (except product 4e, 61% yield, entry 4, Table 3) and the ee values were < 60%, regardless of the substituent being an electron-withdrawing group (chlorine and trifluoromethyl) or an electron-donating group (methoxyl) (entries 1–4, Table 3). Therefore, the reaction showed highest enantioselectivity and best chemical yields with unsubstituted benzaldehyde.
Table 3. Enantioselective Mannich reaction of 2-amino-1, 3, 4-thiadiazole, aldehyde, and malonate catalyzed by the SQ catalyst a.
Table 3. Enantioselective Mannich reaction of 2-amino-1, 3, 4-thiadiazole, aldehyde, and malonate catalyzed by the SQ catalyst a.
Molecules 18 06142 i003
Entry4R1R2Time (h)Yield b (%)ee c (%)
14a2, 3-di-Cl-Ph-OMe964241
24b3-CF3- Ph-OMe963958
34c2, 3-di-OMe-Ph-OMe974448
44dPh-OMe964591
54e2, 4-di-Cl-Ph-OMe966142
64fPh-OEt935299
a Reactions were carried out with 1.0 mmol of 1, 1.2 mmol of 2, and 1.5 mmol of 3 in 2.0 mL of toluene in the presence of 10 mol% catalyst SQ at 60 °C for 90–110 h. b Isolated yields after chromatographic purification. c ee Determined by HPLC analysis (Chiralpak IA).
2-Amino-1,3,4-thiadiazole (1) aldehyde 2, and dimethyl malonate (or diethyl malonate) 3 were mixed in the presence of catalyst SQ and stirred at 60 °C for 93–97 h. The in situ generation of imine was confirmed by thin-layer chromatography (TLC) and mass spectrometry (MS).
Scheme 3. Proposed mechanism of the asymmetric Mannich reaction catalyzed by squaramide cinchona alkaloid.
Scheme 3. Proposed mechanism of the asymmetric Mannich reaction catalyzed by squaramide cinchona alkaloid.
Molecules 18 06142 g004
We speculate that while the imine was activated by the squaramide moiety through hydrogen bonding, the intermediate transition state (enol form of the malonate) was activated by the basic nitrogen atom in the tertiary amine moiety of the catalyst, leading to a stable transition state (Scheme 3). These speculated interactions in our proposed mechanism might be responsible for the observed stereochemical outcome of the reaction and the enhanced reaction rate.

3. Experimental

3.1. General

Unless otherwise stated, all reagents and reactants were purchased from commercial suppliers. Melting points were determined with a XT-4 binocular microscope (Beijing Tech Instrument Co., Beijing, China) without correction. 1H-NMR, 13C-NMR, and 19F-NMR spectra were recorded on a JEOL ECX 500 NMR spectrometer at room temperature operated at 500 MHz for 1H-NMR, 125 MHz for 13C-NMR, and 470 MHz for 19F-NMR using CDCl3 as solvent and TMS as an internal standard. Infrared spectra were recorded in KBr on a Bruker VECTOR 22 spectrometer, and elemental analysis was performed on an Elemental Vario-III CHN analyzer. The progress of the reactions was monitored by TLC, and preparative TLC was performed on silica gel GF254. High-performance liquid chromatography (HPLC) analysis was performed on an Agilent 1100/1200 series instrument equipped with a quaternary pump using a Daicel Chiralpak IA Column (250 mm × 4.6 mm). UV absorption was monitored at 270 nm. Specific rotations were measured on a WZZ-2S digital polarimeter with a sodium lamp. The intermediate 3-(3,5-bis(trifluoromethyl)phenylamino)-4-methoxycyclobut-3-ene-1,2-dione was prepared according to a literature procedure [26].

3.2. Preparation of the SQ Catalyst (Scheme 1)

A solution of 3-(3,5-bis(trifluoromethyl)phenylamino)-4-methoxycyclobut-3-ene-1,2-dione (0.339 g, 1.0 mmol) in dry DCM (5.0 mL) was added dropwise at room temperature to a solution of 9-amino- (9-deoxyquinine) (0.330 g, 1.02 mmol) in dry DCM (5.0 mL). The reaction mixture was stirred at room temperature for 50–56 h. The solvent was removed in vacuo and the residue was purified by column chromatography (silica gel: ethyl acetate/methanol = 15/1) to generate an amorphous solid (59% yield) with a m.p. of 170–171 °C; [α]D25 +56.8 (c = 0.50, DMSO); 1H-NMR (CDCl3): δ 8.62 (s, 1H), 8.00 (d, J = 5.0 Hz, 1H), 7.70–7.69 (m, 1H), 1.60–7.54 (m, 2H), 7.39 (s, 2H), 7.36 (s, 1H), 6.12 (br s, 1H), 5.77–5.70 (m, 1H), 5.02 (br s, 1H), 4.98 (d, J = 10.0 Hz, 1H), 3.93 (s, 3H), 3.38–3.34 (m, 2H), 3.14–3.12 (m, 1H), 2.80–2.75 (m, 2H), 2.33 (br s, 1H), 2.05 (s, 1H), 1.73 (s, 1H), 1.65 (s, 2H), 0.87 (br s, 1H); 13C-NMR (CDCl3): δ 184.7, 180.7, 168.9, 163.6, 159.3, 147.1, 144.2, 141.0, 140.8, 132.5, 130.4, 128.1, 124.3, 132.2, 122.1, 118.1, 115.4, 114.1, 100.7, 59.8, 55.6, 53.5, 40.5, 39.2, 27.5, 26.9, 25.9; 19F-NMR (CDCl3, ppm): δ -63.09; IR (KBr, cm−1): ν 3212, 3087, 2945, 2877, 1794, 1691, 1623, 1606, 1554, 1509, 1471, 1436, 1380, 1179, 1230, 1181, 1133, 1029, 934, 881, 850, 830, 700, 680. MASS (ESI) m/z calcd. for C32H29F6N4O3 [M+H]+ 631.3, found 631.3.

3.3. Preparation of Chiral Compounds 4a4f

Aldehydes 2 (0.60 mmol) and chiral catalyst SQ (0.005 mmol) were added to a well-stirred solution of 2-amino-1,3,4-thiadiazole (1, 0.50 mmol), and dimethyl malonate (diethyl malonate) 3 (0.75 mmol) in toluene (2.5 mL). The mixtures were stirred at 60 °C for 96 h and reaction progress monitored by TLC. After the reactions were completed, the solvents were evaporated and the crude products were directly purified by preparative TLC (GF254 silica gel) using a mixture of petroleum ether and ethyl acetate (1/1–2/3, v/v) as developing solvent to produce chiral compounds 4a-4f.
Dimethyl 2-((1,3,4-thiadiazol-2-ylamino)(2,3-dichlorophenyl)methyl)malonate [(-)-4a]: White solid, yield 42%; m.p. 127–128 °C; ee 41% as determined by HPLC [Daicel Chiralpak IA, hexane/EtOH = 80/20, 1.0 mL·min−1, λ = 270 nm, tr (major) = 10.83 min, tr (minor) = 13.29 min], [α]D20 −30.2 (c 1.01, CHCl3); 1H-NMR (CDCl3): δ 8.40 (s, 1H, NH), 7.61 (s, 1H, ArH), 7.19–7.16 (m, 2H, ArH), 5.89 (s, 1H, =CH), 4.19 (d, J = 4.6 Hz, 1H, CH), 3.77 (s, 3H, OCH3), 3.66 (s, 3H, OCH3); 13C-NMR (CDCl3): δ 168.4, 168.2, 166.9, 142.7, 137.6, 133.7, 131.3, 130.5, 127.7, 126.3, 57.5, 53.9, 53.4, 52.9; IR (KBr) ν: 3401, 3223, 3024, 2953, 2848, 1749, 1734, 1558, 1506, 1498, 1273, 1247, 1157, 1031, 1039, 893, 788, 752 cm−1; Anal. Calcd for C14H13Cl2N3O4S: C 43.09, H 3.36, N 10.77; found: C 43.26, H 3.18, N 10.64.
Dimethyl 2-((1,3,4-thiadiazol-2-ylamino)(3-(trifluoromethyl)phenyl)methyl) malonate [(-)-4b]: White solid, yield 39%; m.p. 156–157 °C; ee 58% as determined by HPLC [Daicel Chiralpak IA, hexane/EtOH = 80/20, 1.0 mL·min−1, λ = 270 nm, tr (major) = 7.75 min, tr (minor) = 10.46 min], [α]D25 −73.4 (c 0.57, CHCl3); 1H-NMR (CDCl3): δ 8.40 (s, 1H, NH), 7.62–7.59 (m, 2H, ArH), 7.56–7.55(m, 1H, ArH), 7.49–7.47 (m, 1H, ArH), 5.66 (d, J = 5.0 Hz, 1H, =CH), 4.00 (s, 1H, CH), 3.73 (s, 3H, OCH3), 3.69 (s, 3H, OCH3); 13C-NMR (CDCl3): δ 168.3, 168.1, 166.9, 142.6, 139.3, 131.4, 131.1, 130.3, 129.5, 125.3, 123.5, 58.9, 56.7, 53.3, 53.1; 19F-NMR (CDCl3): δ -62.7; IR (KBr): ν 3445, 3225, 3024, 2920, 2851, 1747, 1722, 1558, 1506, 1458, 1437, 1329, 1265, 1163, 1072, 1024, 893, 704 cm−1; Anal. Calcd for C15H14F3N3O4S: C 46.27, H 3.62, N 10.79; found: C 46.59, H 3.42, N 10.54.
Dimethyl 2-((1,3,4-thiadiazol-2-ylamino)(2,3-dimethoxyphenyl)methyl) malonate [(-)-4c]: White solid, yield 44%; m.p. 102–103 °C; ee 48% as determined by HPLC [Daicel Chiralpak IA, hexane/EtOH = 80/20, 1.0 mL·min−1, λ = 270 nm, tr (major) = 10.83 min, tr (minor) = 12.43 min], [α]D20 −22.4 (c 0.65, CHCl3); 1H-NMR (CDCl3): δ 8.37 (s, 1H, NH), 6.98–6.97 (m, 1H, ArH), 6.96–6.95 (m, 1H, ArH), 6.86–6.85 (m, 1H, ArH), 5.62 (d, J = 5.0 Hz, 1H, =CH), 4.14 (d, J = 5.0 Hz, 1H, CH), 4.03 (s, 3H, OCH3), 3.86 (s, 3H, OCH3), 3.71 (s, 3H, CH3), 3.65 (s, 3H, CH3); 13C-NMR (CDCl3): δ 169.0, 168.6, 167.3, 152.6, 146.5, 142.3, 130.8, 124.0, 119.5, 112.7, 60.9, 56.7, 55.8, 55.7, 53.1, 52.8; IR (KBr): ν 3443, 3186, 3107, 2943, 2837, 1761, 1734, 1558, 1481, 1437, 1364, 1271, 1223, 1063, 1001, 812, 794, 743 cm−1; Anal. Calcd for C16H19N3O6S: C 50.39, H 5.02, N 11.02; found: C 50.60, H 5.09, N 11.16.
Dimethyl 2-((1,3,4-thiadiazol-2-ylamino)(phenyl)methyl)malonate [(-)-4d]: White solid, yield 45%; m.p. 162–163 °C; ee 91% as determined by HPLC [Daicel Chiralpak IA, hexane/EtOH = 80/20, 1.0 mL·min−1, λ = 270 nm, tr (major) = 9.12 min, tr (minor) = 11.53 min], [α]D20 −75.2 (c = 1.00, CHCl3); 1H-NMR (CDCl3): δ 8.36 (s, 1H, NH), 7.39–7.38 (d, J = 5.0 Hz, 2H, ArH), 7.35–7.32 (m, 2H, ArH), 7.30–7.28 (m, 1H, ArH), 5.39 (d, J = 6.3 Hz, 1H, =CH), 4.03 (d, J = 6.3 Hz, 1H, CH), 3.69 (s, 3H, OCH3), 3.67 (s, 3H, OCH3); 13C-NMR (CDCl3): δ 169.5, 168.2, 167.0, 142.1, 137.6, 130.1, 128.9, 128.5, 128.4, 126.9, 60.5, 57.4, 53.1, 53.0; IR (KBr): ν 3221, 3011, 2953, 1734, 1558, 1506, 1435, 1259, 1238, 1060, 1022, 891, 769, 704 cm−1; Anal. Calcd for C14H15N3O4S: C 52.33, H 4.70, N 13.08; found: C 52.44, H 4.63, N 13.10.
Diethyl 2-((1,3,4-thiadiazol-2-ylamino)(2,4-dichlorophenyl)methyl)malonate [(-)-4e]: White solid, yield 61%; m.p. 142–143 °C; ee 42% as determined by HPLC [Daicel Chiralpak IA, hexane/EtOH = 80/20, 1.0 mL·min−1, λ = 270 nm, tr (major) = 8.87 min, tr (minor) = 13.87 min], [α]D20 −151.3 (c = 0.84, CHCl3); 1H-NMR (CDCl3): δ 8.39 (s, 1H, NH), 7.42–7.41 (m, 1H, ArH), 7.40–7.38 (m, 1H, ArH), 7.22–7.21 (m, 1H, ArH), 5.80 (d, J = 4.6 Hz, 1H, =CH), 4.23–4.18 (m, 2H, OCH2), 4.11–4.08 (m, 2H, OCH2), 4.06 (d, J = 6.3 Hz, 1H, CH), 1.22 (t, J = 6.9 Hz, 3H, CH3), 1.17 (t, J = 7.1 Hz, 3H, CH3); 13C-NMR (CDCl3): δ 168.3, 168.0, 166.5, 142.6, 134.8, 134.0, 133.8, 129.8, 129.4, 127.7, 62.5, 62.2, 56.8, 54.4, 14.0, 13.9; IR (KBr): ν 3362, 3109, 3088, 2990, 2938, 1738, 1719, 1585, 1558, 1497, 1472, 1298, 1240, 1171, 1099, 1059, 866, 781, 743 cm−1; Anal. Calcd for C16H17Cl2N3O4S: C 45.94, H 4.10, N 10.05; found: C 45.75, H 4.00, N 10.10.
Diethyl 2-((1,3,4-thiadiazol-2-ylamino)(phenyl)methyl)malonate [(-)-4f]: White solid, yield 52%; m.p. 120–121 °C; ee 99% as determined by HPLC [Daicel Chiralpak IA, hexane/EtOH = 80/20, 1.0 mL·min−1, λ = 270 nm, tr (major) = 5.61 min, tr (minor) = 9.50 min], [α]D20 −29.2 (c = 0.89, CHCl3); 1H-NMR (CDCl3): δ 8.36 (s, 1H, NH), 7.38–7.37 (m, 2H, ArH), 7.35–7.32 (m, 2H, ArH), 7.27–7.26 (m, 1H, ArH), 5.51 (s, 1H, =CH), 4.19–4.12 (m, 4H, 2OCH2), 3.95 (d, J = 5.2 Hz, 1H, CH), 1.18 (t, J = 7.2 Hz, 3H, CH3), 1.15 (t, J = 7.2 Hz, 3H, CH3); 13C-NMR (CDCl3): δ 169.1, 168.7, 166.6, 142.1, 137.9, 129.9, 128.4, 127.0, 62.3, 62.1, 60.3, 57.5, 14.0, 13.9; IR (KBr): ν 3210, 3011, 2992, 2922, 1749, 1742, 1653, 1558, 1506, 1458, 1370, 1314, 1260, 1152, 1032, 891, 876, 702 cm−1; Anal. Calcd for C16H19 N3O4S: C 55.00, H 5.48, N 12.03; found: C 55.11, H 5.26, N 12.05.

4. Conclusions

In conclusion, we have developed a convenient one-pot synthesis of novel β-amino acid derivatives bearing a 1,3,4-thiadiazole moiety on nitrogen which have valuable applications in medicinal and chemical synthesis and studies using an enantioselective Mannich reaction catalyzed by the chiral squaramide cinchona alkaloid catalyst SQ. The desired β-amino acid derivatives were produced in moderate yields (39%–61%) and with moderate to excellent enantioselectivities (41%–99%). Further research aimed at investigating the mechanism and scope of the catalysts and the reactions, as well as the activity of the Mannich products against plant viruses, is underway and will be reported in due course.

Supplementary Materials

The NMR spectra and HPLC chromatographs of catalyst SQ and compounds 4a4f were provided as supplementary materials can be accessed at: https://www.mdpi.com/1420-3049/18/6/6142/s1.

Acknowledgments

We gratefully acknowledge the National Natural Science Foundation of China (No. 2010CB126105) and the National Key Technologies R&D Program of China (No. 2011BAE06B05-6) for supporting the project.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Seebach, D.; Gardiner, J. Beta-peptidic peptidomimetics. Acc. Chem. Res. 2008, 41, 1366–1375. [Google Scholar] [CrossRef]
  2. Weiner, B.; Baeza, A.; Jerphagnon, T.; Feringa, B.L. Aldehyde selective wacker oxidations of phthalimide protected allylic amines: A new catalytic route to β-amino acids. J. Am. Chem. Soc. 2009, 131, 9473–9474. [Google Scholar] [CrossRef]
  3. Gellman, S.H. Foldamers: A manifesto. Acc. Chem. Res. 1998, 31, 173–180. [Google Scholar] [CrossRef]
  4. Gademann, K.; Hintermann, T.; Schreiber, J.V. Beta-peptides: Twisting and turning. Curr. Med. Chem. 1999, 6, 905–925. [Google Scholar]
  5. Hill, D.J.; Mio, M.J.; Prince, R.B.; Hughes, T.S.; Moore, J.S. A field guide to foldamers. Chem. Rev. 2001, 101, 3893–4011. [Google Scholar] [CrossRef]
  6. Cheng, R.P.; Gellman, S.H.; DeGrado, W.F. β-peptides: From structure to function. Chem. Rev. 2001, 101, 3219–3232. [Google Scholar] [CrossRef]
  7. Steer, D.L.; Lew, R.A.; Perlmutter, P.; Smith, A.I.; Aguilar, M.I. β-amino acids: Versatile peptidomimetics. Curr. Med. Chem. 2002, 9, 811–822. [Google Scholar] [CrossRef]
  8. Miyabe, H.; Fujii, K.; Naito, T. Highly diastereoselective radical addition to oxime ethers: Asymmetric synthesis of β-amino acids. Org. Lett. 1999, 1, 569–572. [Google Scholar] [CrossRef]
  9. Abele, S.; Seebach, D. Preparation of achiral and of enantiopure geminally disubstituted β-amino acids for β-peptide synthesis. Eur. J. Org. Chem. 2000, 1, 1–15. [Google Scholar] [CrossRef]
  10. Seki, M.; Shimizu, T.; Matsumoto, K. Stereoselective synthesis of β-benzyl-α-alkyl-β-amino acids from L-aspartic acid. J. Org. Chem. 2000, 65, 1298–1304. [Google Scholar] [CrossRef]
  11. Albertina, G.M.; Elena, M.; José, A.C.; Ángel, Á.L.; Graciela, Y.M.; Vicenc, B.; Rosa, M.O. Reaction between N-alkylhydroxilamines and chiral enoate esters: More experimental evidence for a cycloaddition-like process, a rationale based on DFT theoretical calculations and stereoselective synthesis of new enantiopure β-amino acids. J. Org. Chem. 2002, 67, 2402–2410. [Google Scholar]
  12. Luisi, R.; Capriati, V.; Degennaro, L.; Florio, S. Oxazolinyloxiranyllithium-mediated stereoselective synthesis of a-epoxy-b-amino acids. Org. Lett. 2003, 5, 2723–2726. [Google Scholar]
  13. Swiderska, M.A.; Stewart, J.D. Asymmetric bioreductions of β-nitro acrylates as a route to chiral β-amino acids. Org. Lett. 2006, 8, 6131–6133. [Google Scholar]
  14. Saavedra, C.; Hernández, R.; Boto, A.; Álvarez, E. Catalytic, One-pot synthesis of β-amino acids from α-amino acids. Preparation of α,β-peptide derivatives. J. Org. Chem. 2009, 74, 4655–4665. [Google Scholar]
  15. Juaristi, E.; Soloshonok, V.A. Enantioselective Synthesis of β-amino Acids, 2nd ed; John Wiley & Sons, Inc.: Hoboken, NJ, USA, 2005. [Google Scholar]
  16. Juaristi, E.; Quintana, D.; Escalante, J. Enantioselective synthesis of β-amino acids. Aldrichim. Acta 1994, 27, 3–11. [Google Scholar]
  17. Cole, D.C. Recent stereoselective synthetic approaches to β-amino acids. Tetrahedron. 1994, 50, 9517–9582. [Google Scholar]
  18. Cardillo, G.; Tomasini, C. Asymmetric synthesis of ß-amino acids and α-substituted β-amino acids. Chem. Soc. Rev. 1996, 25, 117–128. [Google Scholar]
  19. Juaristi, E. Enantioselective Synthesis of β-amino Acids; Wiley-VCH: New York, NY, USA, 1997; chapters: 11–13. [Google Scholar]
  20. Juaristi, E.; López-Ruiz, H. Recent advances in the enantioselective synthesis of beta-amino acids. Curr. Med Chem. 1999, 6, 983–1004. [Google Scholar]
  21. Liu, M.; Sibi, M.P. Recent advances in the stereoselective synthesis of β-amino acids. Tetrahedron 2002, 58, 7991–8035. [Google Scholar] [CrossRef]
  22. Mohammad, A.; Harish, K.; Sadique, A.J. Synthesis and pharmacological evaluation of condensed heterocyclic 6-substituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives of naproxen. Bioorg. Med. Chem. Lett. 2007, 17, 4504–4508. [Google Scholar]
  23. Mathew, V.; Keshavayya, J.; Vaidya, V.P. Heterocyclic system containing bridgehead nitrogen atomsynthesis and pharmacologicalactivities of some substituted 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles. Eur. J. Med. Chem. 2006, 41, 1048–1058. [Google Scholar] [CrossRef]
  24. Nasser, S.; Khalil, A.M. N- and S-a-L-arabinopyranosyl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles. First synthesis and biological evaluation. Eur. J. Med. Chem. 2007, 42, 1193–1199. [Google Scholar] [CrossRef]
  25. Karegoudar, P.; Prasad, D.J.; Ashok, M.; Mahalinga, M.; Poojary, B.; Holla, B.S. Synthesis, antimicrobial and anti-inflammatory activities of some 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazines bearing trichlorophenyl moiety. Eur. J. Med. Chem. 2008, 43, 808–815. [Google Scholar] [CrossRef]
  26. El-Barbary, A.A.; Abou-El-Ezz, A.Z.; Abdel-Kader, A.A.; El-Daly, M.; Nielsenc, C. Synthesis of some new 4-amino-1,2,4-triazole derivatives as potential anti-HIV and anti-HBV. Phosphorus, Sulfur Silicon. Relat. Elem. 2004, 179, 1497–1508. [Google Scholar] [CrossRef]
  27. Bai, S.; Liang, X.P.; Song, B.A.; Bhadury, P.S.; Hu, D.Y.; Yang, S. Asymmetric Mannich reactions catalyzed by cinchona alkaloid thiourea: Enantioselective one-pot synthesis of novel β-amino ester derivatives. Tetrahedron: Asymmetry. 2011, 22, 518–523. [Google Scholar] [CrossRef]
  28. Li, L.; Song, B.A.; Bhadury, P.S.; Zhang, Y.P.; Hu, D.Y.; Yang, S. Enantioselective synthesis of β-amino esters bearing a benzothiazole moiety via a Mannich-type reaction catalyzed by a cinchona alkaloid derivative. Eur. J. Org. Chem. 2011, 25, 4743–4376. [Google Scholar]
  29. Lin, P.; Song, B.A.; Bhadury, P.S.; Hu, D.Y.; Zhang, Y.P.; Jin, L.H.; Yang, S. Chiral cinchona alkaloid-thiourea catalyzed Mannich reaction for enantioselective synthesis of β-amino ketones bearing benzothiazol moiety. Chin. J. Chem. 2011, 29, 2433–2438. [Google Scholar] [CrossRef]
  30. Vakulya, B.; Varga, S.; Csámpai, A.; Soós, T. Highly enantioselective conjugate addition of nitromethane to chalcones using bifunctional cinchona organocatalysts. Org. Lett. 2005, 7, 1967–1969. [Google Scholar] [CrossRef]
  31. Malerich, J.P.; Hagihara, K.; Rawal, V.H. Chiral squaramide derivatives are excellent hydrogen bond donor catalysts. J. Am. Chem.Soc. 2008, 130, 14416–14417. [Google Scholar] [CrossRef]
  32. Yang, W.; Du, D.M. Highly Enantioselective Michael addition of nitroalkanes to chalcones using chiral squaramides as hydrogen bonding organocatalysts. Org. Lett. 2010, 12, 5450–5453. [Google Scholar] [CrossRef]
  33. Jang, H.B.; Rho, H.S.; Oh, J.S.; Nam, E.H.; Park, S.F.; Bae, H.Y.; Song, C.E. DOSY NMR for monitoring self aggregation of bifunctional organocatalysts: Increasing enantioselectivity with decreasing catalyst concentration. Org. Biomol. Chem. 2010, 8, 3918–3922. [Google Scholar] [CrossRef]
  34. Jiang, H.; Paixão, M.W.; Monge, D.; Jørgensen, K.A. Acyl phosphonates: Good hydrogen bond acceptors and ester/amide equivalents in asymmetric organocatalysis. J. Am. Chem. Soc. 2010, 132, 2775–2783. [Google Scholar] [CrossRef]
  • Sample Availability: Samples of the compounds are available from the authors.

Share and Cite

MDPI and ACS Style

Zhang, K.; Liang, X.; He, M.; Wu, J.; Zhang, Y.; Xue, W.; Jin, L.; Yang, S.; Hu, D. One-Pot Synthesis of Novel Chiral β-Amino Acid Derivatives by Enantioselective Mannich Reactions Catalyzed by Squaramide Cinchona Alkaloids. Molecules 2013, 18, 6142-6152. https://doi.org/10.3390/molecules18066142

AMA Style

Zhang K, Liang X, He M, Wu J, Zhang Y, Xue W, Jin L, Yang S, Hu D. One-Pot Synthesis of Novel Chiral β-Amino Acid Derivatives by Enantioselective Mannich Reactions Catalyzed by Squaramide Cinchona Alkaloids. Molecules. 2013; 18(6):6142-6152. https://doi.org/10.3390/molecules18066142

Chicago/Turabian Style

Zhang, Kankan, Xueping Liang, Ming He, Jian Wu, Yuping Zhang, Wei Xue, Linhong Jin, Song Yang, and Deyu Hu. 2013. "One-Pot Synthesis of Novel Chiral β-Amino Acid Derivatives by Enantioselective Mannich Reactions Catalyzed by Squaramide Cinchona Alkaloids" Molecules 18, no. 6: 6142-6152. https://doi.org/10.3390/molecules18066142

Article Metrics

Back to TopTop