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Keywords = thiourea derived from squaramide cinchona alkaloid

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41 pages, 13502 KB  
Review
Recent Advances in the Enantioselective Organocatalytic [4+2] Cycloadditions
by Tomasz Bauer
Molecules 2025, 30(9), 1978; https://doi.org/10.3390/molecules30091978 - 29 Apr 2025
Cited by 4 | Viewed by 2784
Abstract
This review covers the recent advances in asymmetric organocatalytic Diels–Alder reactions published since the beginning of 2015. It describes recent approaches to enantioselective [4+2] cycloadditions based on the application of various types of chiral organocatalysts. Full article
(This article belongs to the Special Issue Organocatalysis: Past, Present, and Future Perspectives)
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11 pages, 320 KB  
Article
One-Pot Synthesis of Novel Chiral β-Amino Acid Derivatives by Enantioselective Mannich Reactions Catalyzed by Squaramide Cinchona Alkaloids
by Kankan Zhang, Xueping Liang, Ming He, Jian Wu, Yuping Zhang, Wei Xue, Linhong Jin, Song Yang and Deyu Hu
Molecules 2013, 18(6), 6142-6152; https://doi.org/10.3390/molecules18066142 - 23 May 2013
Cited by 18 | Viewed by 8246
Abstract
An efficient one-pot synthesis of novel β-amino acid derivatives containing a thiadiazole moiety was developed using a chiral squaramide cinchona alkaloid as organocatalyst. The reactions afforded chiral β-amino acid derivatives in moderate yields and with moderate to excellent enantioselectivities. The present [...] Read more.
An efficient one-pot synthesis of novel β-amino acid derivatives containing a thiadiazole moiety was developed using a chiral squaramide cinchona alkaloid as organocatalyst. The reactions afforded chiral β-amino acid derivatives in moderate yields and with moderate to excellent enantioselectivities. The present study demonstrated for the first time the use of a Mannich reaction catalyzed by a chiral bifunctional organocatalyst for the one-pot synthesis of novel β-amino acid derivatives bearing a 1,3,4-thiadiazole moiety on nitrogen. Full article
(This article belongs to the Section Organic Chemistry)
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