Next Article in Journal
Antioxidant Activity of Extracts of Momordica Foetida Schumach. et Thonn.
Previous Article in Journal
Click-to-Chelate: Development of Technetium and Rhenium-Tricarbonyl Labeled Radiopharmaceuticals
Article Menu

Export Article

Open AccessArticle
Molecules 2013, 18(3), 3227-3240; https://doi.org/10.3390/molecules18033227

Synthesis and Antimicrobial Activity of Novel Substituted Ethyl 2-(Quinolin-4-yl)-propanoates

Biomedical Research Centre, Sheffield Hallam University, Howard Street, Sheffield, S1 1WB, UK
*
Author to whom correspondence should be addressed.
Received: 30 January 2013 / Revised: 1 March 2013 / Accepted: 4 March 2013 / Published: 13 March 2013
(This article belongs to the Section Organic Chemistry)
Full-Text   |   PDF [437 KB, uploaded 18 June 2014]   |  

Abstract

Substituted 4-hydroxyquinolines were synthesized from anilines and diethyl 2-(ethoxymethylene)malonate by the Gould-Jacobs reaction via cyclization of the intermediate anilinomethylenemalonate followed by hydrolysis and decarboxylation. The 4-hydroxyquinolines reacted with phosphorous oxychloride to form 4-chloroquinolines, which reacted on heating with diethyl sodiomethylmalonate in DMF to yield moderate yields of substituted ethyl 2-(quinolin-4-yl)propanoates, many of which showed potent antimicrobial activity against Helicobacter pylori. View Full-Text
Keywords: synthesis; 4-quinolylpropionic esters; Gould-Jacobs reaction; anti-microbial activity synthesis; 4-quinolylpropionic esters; Gould-Jacobs reaction; anti-microbial activity
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Khan, M.A.; Miller, K.; Rainsford, K.D.; Zhou, Y. Synthesis and Antimicrobial Activity of Novel Substituted Ethyl 2-(Quinolin-4-yl)-propanoates. Molecules 2013, 18, 3227-3240.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top