Next Article in Journal
Fluorescent Probes for Nucleic Acid Visualization in Fixed and Live Cells
Previous Article in Journal
Discrimination of Multi-Origin Chinese Herbal Medicines Using Gas Chromatography-Mass Spectrometry-Based Fatty Acid Profiling
Open AccessArticle

Identification and Physicochemical Characteristics of Temozolomide Process-Related Impurities

1
Pharmaceutical Research Institute (PRI), Warszawa 01-793, Poland
2
Faculty of Chemistry, University of Warsaw, Warszawa 02-093, Poland
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(12), 15344-15356; https://doi.org/10.3390/molecules181215344
Received: 24 October 2013 / Revised: 27 November 2013 / Accepted: 3 December 2013 / Published: 11 December 2013
(This article belongs to the Section Medicinal Chemistry)
In this article the crystal structures of the starting material TZ-5 and the key intermediate TZ-6 of temozolomide (TZ-7), an anticancer therapeutic agent, are presented, together with their spectroscopic and thermal characteristics. Both compounds crystallize in the triclinic P-1 space group. X-ray crystallography studies proved that the compound TZ-6 exists as a monohydrate. A complete structural assignment was obtained for the signals in the 1H-, 13C- and 15N-nuclear magnetic resonance spectra and the structures were confirmed by Fourier-Transform infrared and Raman spectroscopy. The article describes the importance of the high purity of TZ-6 during the small-scale plant production of TZ-7 in a desired polymorphic form III with the purity higher than 99.50%, according to an HPLC method. View Full-Text
Keywords: temozolomide intermediate; X-ray crystallography; nuclear magnetic resonance; high-performance liquid chromatography temozolomide intermediate; X-ray crystallography; nuclear magnetic resonance; high-performance liquid chromatography
Show Figures

Figure 1

MDPI and ACS Style

Łaszcz, M.; Kubiszewski, M.; Jedynak, Ł.; Kaczmarska, M.; Kaczmarek, Ł.; Łuniewski, W.; Gabarski, K.; Witkowska, A.; Kuziak, K.; Malińska, M. Identification and Physicochemical Characteristics of Temozolomide Process-Related Impurities. Molecules 2013, 18, 15344-15356.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop