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Astataricusones A–D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.

by Wen-Bing Zhou 1,2,†, Guang-Zhi Zeng 1,†, Hui-Min Xu 1,2, Wen-Jun He 1 and Ning-Hua Tan 1,*
1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming 650201, China
2
University of Chinese Academy of Sciences, Beijing 100049, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2013, 18(12), 14585-14596; https://doi.org/10.3390/molecules181214585
Received: 9 October 2013 / Revised: 13 November 2013 / Accepted: 15 November 2013 / Published: 25 November 2013
(This article belongs to the Section Natural Products Chemistry)
Five new shionane-type triterpenes, astataricusones A–D (compounds 14) and astataricusol A (5), together with one known shionane-type triterpene 6 were obtained from the roots and rhizomes of Aster tataricus L. f. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configurations of 1 and 4 was determined by single crystal X-ray diffraction and CD analysis. Compound 2 showed inhibitory activity on HBsAg secretion with an IC50 value of 23.5 μM, while 2 and 6 showed inhibitory activities on HBeAg secretion with IC50 values of 18.6 and 40.5 μM, and cytotoxicity on HepG 2.2.15 cells with CC50 values of 172.4 and 137.7 μM, respectively. Compounds 2 and 6 also exhibited inhibitory activities on HBV DNA replication with IC50 values of 2.7 and 30.7 μM, respectively. View Full-Text
Keywords: Aster tataricus; shionane-type triterpenes; astataricusones A–D; astataricusol A; anti-HBV Aster tataricus; shionane-type triterpenes; astataricusones A–D; astataricusol A; anti-HBV
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Zhou, W.-B.; Zeng, G.-Z.; Xu, H.-M.; He, W.-J.; Tan, N.-H. Astataricusones A–D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.. Molecules 2013, 18, 14585-14596.

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