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Keywords = astataricusol A

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12 pages, 388 KiB  
Article
Astataricusones A–D and Astataricusol A, Five New Anti-HBV Shionane-Type Triterpenes from Aster tataricus L. f.
by Wen-Bing Zhou, Guang-Zhi Zeng, Hui-Min Xu, Wen-Jun He and Ning-Hua Tan
Molecules 2013, 18(12), 14585-14596; https://doi.org/10.3390/molecules181214585 - 25 Nov 2013
Cited by 26 | Viewed by 6153
Abstract
Five new shionane-type triterpenes, astataricusones A–D (compounds 14) and astataricusol A (5), together with one known shionane-type triterpene 6 were obtained from the roots and rhizomes of Aster tataricus L. f. Their structures were elucidated on the basis [...] Read more.
Five new shionane-type triterpenes, astataricusones A–D (compounds 14) and astataricusol A (5), together with one known shionane-type triterpene 6 were obtained from the roots and rhizomes of Aster tataricus L. f. Their structures were elucidated on the basis of spectroscopic data, mainly NMR and MS data. The absolute configurations of 1 and 4 was determined by single crystal X-ray diffraction and CD analysis. Compound 2 showed inhibitory activity on HBsAg secretion with an IC50 value of 23.5 μM, while 2 and 6 showed inhibitory activities on HBeAg secretion with IC50 values of 18.6 and 40.5 μM, and cytotoxicity on HepG 2.2.15 cells with CC50 values of 172.4 and 137.7 μM, respectively. Compounds 2 and 6 also exhibited inhibitory activities on HBV DNA replication with IC50 values of 2.7 and 30.7 μM, respectively. Full article
(This article belongs to the Section Natural Products Chemistry)
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