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Open AccessArticle

A New Tetrahydrofuran Lignan Diglycoside from Viola tianshanica Maxim

by Yan Qin 1, Chengle Yin 1 and Zhihong Cheng 1,2,*
1
Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China
2
Key Laboratory of Modern Chinese Preparation, Jiangxi University of Traditional Chinese Medicine, Ministry of Education of China, Nanchang 330004, China
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(11), 13636-13644; https://doi.org/10.3390/molecules181113636
Received: 11 September 2013 / Revised: 10 October 2013 / Accepted: 18 October 2013 / Published: 4 November 2013
(This article belongs to the Section Natural Products Chemistry)
A new lignan glycoside, tianshanoside A (1), together with a known phenylpropanoid glycoside, syringin (2) and two known lignan glycosides, picraquassioside C (3), and aketrilignoside B (4), were isolated from the whole plant of Viola tianshanica Maxim. The structure of the new compound was elucidated by extensive NMR (1H, 13C, COSY, HSQC, HMBC and ROESY) and high resolution mass spectrometry analysis. The three lignans 1, 3, and 4 did not exhibit significant cytotoxicity against human gastric cancer Ags cells or HepG2 liver cancer cells. This is the first report of the isolation of a lignan skeleton from the genus Viola L. View Full-Text
Keywords: Viola tianshanica; lignan; tianshanoside A; cytotoxicity Viola tianshanica; lignan; tianshanoside A; cytotoxicity
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Qin, Y.; Yin, C.; Cheng, Z. A New Tetrahydrofuran Lignan Diglycoside from Viola tianshanica Maxim. Molecules 2013, 18, 13636-13644.

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