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Open AccessArticle

An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI)

Department of Biosciences and Nutrition, Karolinska Institute (KI), Novum, Huddinge SE-141 83, Sweden
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Molecules 2013, 18(10), 12740-12750; https://doi.org/10.3390/molecules181012740
Received: 2 September 2013 / Revised: 2 October 2013 / Accepted: 9 October 2013 / Published: 15 October 2013
(This article belongs to the Special Issue Synthesis of Nucleosides, Nucleotides and Their Derivatives)
An efficient and facile strategy has been developed for bromination of nucleosides using sodium monobromoisocyanurate (SMBI). Our methodology demonstrates bromination at the C-5 position of pyrimidine nucleosides and the C-8 position of purine nucleosides. Unprotected and also several protected nucleosides were brominated in moderate to high yields following this procedure. View Full-Text
Keywords: bromination; sodium monobromoisocyanurate (SMBI); pyridine-based nucleosides; purine-based nucleosides; bromonucleosides bromination; sodium monobromoisocyanurate (SMBI); pyridine-based nucleosides; purine-based nucleosides; bromonucleosides
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MDPI and ACS Style

Maity, J.; Stromberg, R. An Efficient and Facile Methodology for Bromination of Pyrimidine and Purine Nucleosides with Sodium Monobromoisocyanurate (SMBI). Molecules 2013, 18, 12740-12750.

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