Next Article in Journal
G-Quadruplexes as Potential Therapeutic Targets for Embryonal Tumors
Previous Article in Journal
Ultrasound-Assisted Extraction (UAE) and Solvent Extraction of Papaya Seed Oil: Yield, Fatty Acid Composition and Triacylglycerol Profile
Open AccessArticle

Copper-Catalyzed Three- Five- or Seven-Component Coupling Reactions: The Selective Synthesis of Cyanomethylamines, N,N-Bis(Cyanomethyl)Amines and N,N'-Bis(Cyanomethyl)Methylenediamines Based on a Strecker-Type Synthesis

Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan
*
Author to whom correspondence should be addressed.
Molecules 2013, 18(10), 12488-12499; https://doi.org/10.3390/molecules181012488
Received: 28 August 2013 / Revised: 27 September 2013 / Accepted: 27 September 2013 / Published: 10 October 2013
(This article belongs to the Section Organic Chemistry)
We have demonstrated that a cooperative catalytic system comprised of CuCl and Cu(OTf)2 could be used to effectively catalyse the three-, five- and seven-component coupling reactions of aliphatic or aromatic amines, formaldehyde, and trimethylsilyl cyanide (TMSCN), and selectively produce in good yields the corresponding cyanomethylamines, N,N-bis(cyanomethyl)amines and N,N'-bis(cyanomethyl)methylenediamines. View Full-Text
Keywords: multi-component coupling; Strecker-type reaction; nitriles; copper multi-component coupling; Strecker-type reaction; nitriles; copper
Show Figures

Graphical abstract

MDPI and ACS Style

Sakai, N.; Takahashi, N.; Inoda, D.; Ikeda, R.; Konakahara, T. Copper-Catalyzed Three- Five- or Seven-Component Coupling Reactions: The Selective Synthesis of Cyanomethylamines, N,N-Bis(Cyanomethyl)Amines and N,N'-Bis(Cyanomethyl)Methylenediamines Based on a Strecker-Type Synthesis. Molecules 2013, 18, 12488-12499.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop