Mechanical, Rheological and Release Behaviors of a Poloxamer 407/ Poloxamer 188/Carbopol 940 Thermosensitive Composite Hydrogel
Abstract
:1. Introduction
2. Results and Discussion
2.1. Characterization of TCH
2.1.1. Phase Transition Temperature
Formulation | hydrogel temperature (°C) |
---|---|
F0 | 37.26 ± 0.26 |
F1 | 37.52 ± 0.35 |
F2 | 37.70 ± 0.03 |
F3 | 38.34 ± 0.15 |
2.1.2. Hydrogel Texture
Formulation | Hardness (a1)/(Kg) | Cohesiveness (a2)/(Kg) | Strength (A1)/(Kg) | Adhesiveness (A2)/(Kg) |
---|---|---|---|---|
F0 | 0.025 | 0.022 | 0.110 | 0.036 |
F1 | 0.042 | 0.040 | 0.189 | 0.037 |
F2 | 0.049 | 0.046 | 0.207 | 0.070 |
F3 | 0.064 | 0.064 | 0.307 | 0.105 |
2.1.3. Rheological Properties
Formulation | G′ max/(Pa) | G′′max/(Pa) | ηmax/(Pas) |
---|---|---|---|
F0 | 7,760.00 | 1,274.00 | 1,252.00 |
F1 | 1,883.89 | 23.85 | 32.53 |
F2 | 201.00 | 32.30 | 32.39 |
F3 | 157.50 | 36.28 | 25.73 |
2.2. In-vitro Release
3. Experimental
3.1. Materials
3.2. Preparation of TCH
Ingredients (w/v) | F0 (%) | F1 (%) | F2 (%) | F3 (%) |
---|---|---|---|---|
P407 | 24 | 24 | 24 | 24 |
P188 | 16 | 16 | 16 | 16 |
C940 | 0.1 | 0.1 | 0.1 | 0.1 |
NB/HP-β-CD | 0 | 1 | 2 | 3 |
3.3. Characterization of TCH
3.3.1. Measurement of Phase Transition Temperature
3.3.2. Hydrogel Texture
3.3.3. Rheological Properties of the Hydrogels
3.4. In-Vitro Release
3.5. Determination of the Calibration Curve of NB
3.5.1. Gas Chromatography (GC)
3.5.2. Measurement of the Calibration Curve of NB
3.6. Statistical Analysis
4. Conclusions
Acknowledgments
Conflicts of Interest
References
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Chen, J.; Zhou, R.; Li, L.; Li, B.; Zhang, X.; Su, J. Mechanical, Rheological and Release Behaviors of a Poloxamer 407/ Poloxamer 188/Carbopol 940 Thermosensitive Composite Hydrogel. Molecules 2013, 18, 12415-12425. https://doi.org/10.3390/molecules181012415
Chen J, Zhou R, Li L, Li B, Zhang X, Su J. Mechanical, Rheological and Release Behaviors of a Poloxamer 407/ Poloxamer 188/Carbopol 940 Thermosensitive Composite Hydrogel. Molecules. 2013; 18(10):12415-12425. https://doi.org/10.3390/molecules181012415
Chicago/Turabian StyleChen, Jianping, Rong Zhou, Lin Li, Bing Li, Xia Zhang, and Jianyu Su. 2013. "Mechanical, Rheological and Release Behaviors of a Poloxamer 407/ Poloxamer 188/Carbopol 940 Thermosensitive Composite Hydrogel" Molecules 18, no. 10: 12415-12425. https://doi.org/10.3390/molecules181012415