Synthesis and Antibacterial Activities of Novel 4-Hydroxy-7-hydroxy- and 3-Carboxycoumarin Derivatives
Abstract
:1. Introduction
2. Results and Discussion
MIC (μg/mL) a | ||||
---|---|---|---|---|
Gram (+) bacteria b | Gram (−) bacteria b | |||
Compds. | B. s. | S. a. | E. c. | P. a. |
3a | >256 | >256 | >256 | >256 |
3a1 | >256 | >256 | >256 | >256 |
3a2 | 128 | >256 | >256 | >256 |
3b | 128 | >256 | 128 | >256 |
3b1 | 128 | 256 | 256 | >256 |
3b2 | >256 | >256 | >256 | >256 |
3c | 32 | 32 | >256 | >256 |
3c1 | 32 | >256 | >256 | >256 |
3c2 | >256 | >256 | >256 | >256 |
4a | 128 | >256 | >256 | >256 |
4a1 | >256 | >256 | >256 | >256 |
4a2 | 64 | >256 | >256 | >256 |
4b | 64 | 128 | 256 | >256 |
4b1 | >256 | >256 | >256 | >256 |
4b2 | 128 | >256 | >256 | >256 |
4c | 16 | 16 | 128 | >256 |
4c1 | >256 | >256 | >256 | >256 |
4c2 | 64 | 32 | >256 | >256 |
7d | 64 | 64 | >256 | >256 |
7e | >256 | >256 | >256 | >256 |
7f | 8 | 8 | >256 | >256 |
7g | >256 | >256 | >256 | >256 |
7h | >256 | >256 | >256 | >256 |
8i | >256 | >256 | >256 | >256 |
8j | >256 | >256 | >256 | >256 |
10k | >128 | >128 | 128 | >128 |
10l | >128 | >128 | >128 | >128 |
10m | >128 | >128 | 128 | >128 |
10n | >128 | >128 | >128 | >128 |
10o | >128 | >128 | >128 | >128 |
10p | >128 | >128 | >128 | >128 |
10q | >128 | >128 | >128 | >128 |
10r | >128 | >128 | >128 | >128 |
11k | >128 | >128 | >128 | >128 |
14 | >128 | >128 | >128 | >128 |
15 | >128 | >128 | >128 | >128 |
16 | >128 | >128 | >128 | >128 |
17 | >128 | >128 | >128 | >128 |
18 | >128 | >128 | >128 | >128 |
19 | >128 | >128 | >128 | >128 |
20 | >128 | >128 | >128 | >128 |
21 | >128 | >128 | >128 | >128 |
PenicillinG c | 8 | 0.0625 | - | - |
Amikin | - | - | 1 | 0.125 |
2.1. Chemistry
2.2. Antibacterial Activity Test
3. Experimental
3.1. General
3.2. Preparation of Acylcoumarins
3.3. Preparation of 4-hydroxy-, and 7-hydroxycoumarin Derivatives via Ring Opening of Activated Aziridines
3.4. Preparation of Coumarin Amide Dimers
4. Conclusions
Acknowledgments
References
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Lin, P.-Y.; Yeh, K.-S.; Su, C.-L.; Sheu, S.-Y.; Chen, T.; Ou, K.-L.; Lin, M.-H.; Lee, L.-W. Synthesis and Antibacterial Activities of Novel 4-Hydroxy-7-hydroxy- and 3-Carboxycoumarin Derivatives. Molecules 2012, 17, 10846-10863. https://doi.org/10.3390/molecules170910846
Lin P-Y, Yeh K-S, Su C-L, Sheu S-Y, Chen T, Ou K-L, Lin M-H, Lee L-W. Synthesis and Antibacterial Activities of Novel 4-Hydroxy-7-hydroxy- and 3-Carboxycoumarin Derivatives. Molecules. 2012; 17(9):10846-10863. https://doi.org/10.3390/molecules170910846
Chicago/Turabian StyleLin, Pen-Yuan, Kuang-Sheng Yeh, Chien-Ling Su, Shiow-Yunn Sheu, Tiffany Chen, Keng-Liang Ou, Mei-Hsiang Lin, and Lin-Wen Lee. 2012. "Synthesis and Antibacterial Activities of Novel 4-Hydroxy-7-hydroxy- and 3-Carboxycoumarin Derivatives" Molecules 17, no. 9: 10846-10863. https://doi.org/10.3390/molecules170910846