Next Article in Journal
Synthetic Approaches and Pharmacological Activity of 1,3,4-Oxadiazoles: A Review of the Literature from 2000–2012
Previous Article in Journal
Distribution of Primary and Specialized Metabolites in Nigella sativa Seeds, a Spice with Vast Traditional and Historical Uses
Article Menu

Export Article

Open AccessArticle
Molecules 2012, 17(9), 10178-10191;

A Synthetic Method to Access Symmetric and Non-Symmetric 2-(N,N'-disubstituted)guanidinebenzothiazoles

Departamento de Ciencias Básicas de la Unidad Profesional Interdisciplinaria de Biotecnología del IPN, Av. Acueducto s/n, Barrio la Laguna Ticomán, México, D.F., 07340, Mexico
Author to whom correspondence should be addressed.
Received: 26 June 2012 / Revised: 14 August 2012 / Accepted: 15 August 2012 / Published: 24 August 2012
(This article belongs to the Section Organic Chemistry)
Full-Text   |   PDF [542 KB, uploaded 18 June 2014]   |  


Symmetric and non-symmetric 2-(N-H, N-methyl, N-ethylenyl and N-aryl)guanidinebenzothiazoles were synthesized from the reaction of ammonia, methylamine, pyrrolidine and aniline with dimethyl benzo[d]thiazol-2-yl-carbono-dithioimidate (5) as intermediate. The products were characterized by 1H-, 13C-NMR spectroscopy and three of them by X-ray diffraction analysis. HN-phenyl protons formed intramolecular hydrogen bonds that assist the stereochemistry of the second substituent, whereas the HN-alkyl protons were involved in intermolecular hydrogen bonding. View Full-Text
Keywords: 2-aminobenzothiazole; dithiomethylcarboimidate; isothiourea; benzothiazole; guanidine 2-aminobenzothiazole; dithiomethylcarboimidate; isothiourea; benzothiazole; guanidine

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Cruz, A.; Padilla-Martínez, I.I.; García-Báez, E.V. A Synthetic Method to Access Symmetric and Non-Symmetric 2-(N,N'-disubstituted)guanidinebenzothiazoles. Molecules 2012, 17, 10178-10191.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top