Next Article in Journal
An ent-Kaurane-Type Diterpene in Croton antisyphiliticus Mart.
Previous Article in Journal
Synthesis and Biological Activity of 23-Hydroxybetulinic Acid C-28 Ester Derivatives as Antitumor Agent Candidates
Article Menu

Export Article

Open AccessArticle
Molecules 2012, 17(8), 8842-8850; https://doi.org/10.3390/molecules17088842

Anti-Inflammatory and Analgesic Activity of Total Flavone of Cunninghamia lanceolata

1
Department of Traditional Chinese Medicine, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2
Department of Naval Medicine, Second Military Medical University, Shanghai 200433, China
3
Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
4
Plant Biotechnology Research Center, School of Agriculture and Biology, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, Shanghai Jiao Tong University, Shanghai 200240, China
5
Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
*
Authors to whom correspondence should be addressed.
Received: 21 May 2012 / Revised: 9 July 2012 / Accepted: 13 July 2012 / Published: 25 July 2012
Full-Text   |   PDF [260 KB, uploaded 18 June 2014]   |  

Abstract

The present study was undertaken to investigate the anti-inflammatory and analgesic activity of total flavone of branches and leaves of Cunninghamia lanceolata (TFC) to provide a scientific basis for its clinical use and resource development. TFC was evaluated for anti-inflammatory and analgesic activity in mice or rats using chemical and thermal models of nociception, including acetic acid-induced writhing test, hot plate latency test, formalin test and carrageenan induced paw oedema test. Results showed that TFC given orally can significantly attenuate acetic acid-induced writhing in mice in a dose-dependent manner. In the hot plate latency test, TFC showed common activity in prolonging duration time only at the highest dose (400 mg/kg). Each dose of TFC could not significantly inhibit the first phase but was active in the later phase of formalin-induced pain, whereas morphine showed notable activity in the two phases. In the carrageenan-induced paw oedema model, TFC could significantly and dose-dependently reduce the carrageenan-induced paw edema at the third and fifth hour, and decrease the content of PEG2 in paw edema tissue and that of COX-2 in blood serum. It may be concluded that TFC showed both anti-inflammatory and analgesic effects, showing that it can be of importance in drug development, especially in the field of pain and inflammation. View Full-Text
Keywords: Cunninghamia lanceolata (Lamb.) Hook; total flavone; anti-inflammatory; analgesia Cunninghamia lanceolata (Lamb.) Hook; total flavone; anti-inflammatory; analgesia
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Xin, H.-L.; Zhai, X.-F.; Zheng, X.; Zhang, L.; Wang, Y.-L.; Wang, Z. Anti-Inflammatory and Analgesic Activity of Total Flavone of Cunninghamia lanceolata. Molecules 2012, 17, 8842-8850.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top