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Molecules 2012, 17(7), 8674-8686;

Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives

Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union, Medical College, Beijing 100050, China
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China
Authors to whom correspondence should be addressed.
Received: 8 June 2012 / Revised: 28 June 2012 / Accepted: 13 July 2012 / Published: 23 July 2012
(This article belongs to the Special Issue Heterocycles)
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A series of 3'-aminospiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]-2,5',10'-trione derivatives have been synthesized by a one-pot three-component reaction of isatin, malononitrile or ethyl cyanoacetate and phthalhydrazide catalyzed by piperidine under ultrasound irradiation. For comparison the reactions were carried out under both conventional and ultrasonic conditions. In general, improvement in rates and yields were observed when the reactions were carried out under sonication compared with classical conditions. View Full-Text
Keywords: multicomponent; ultrasound; spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]; spirooxindole multicomponent; ultrasound; spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine]; spirooxindole

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Wang, J.; Bai, X.; Xu, C.; Wang, Y.; Lin, W.; Zou, Y.; Shi, D. Ultrasound-Promoted One-Pot, Three-Component Synthesis of Spiro[indoline-3,1'-pyrazolo[1,2-b]phthalazine] Derivatives. Molecules 2012, 17, 8674-8686.

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