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Molecules 2012, 17(7), 8687-8695; https://doi.org/10.3390/molecules17078687

Buddleja officinalis Maximowicz Extract Inhibits Lipid Accumulation on Adipocyte Differentiation in 3T3-L1 Cells and High-Fat Mice

1
Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 1266, Sinjeong-dong, Jeongeup, Jeonbuk 580-185, Korea
2
Department of Chemistry, Seoul National University, Gwanak-ro, Gwanak-gu, Seoul 151-747, Korea
*
Authors to whom correspondence should be addressed.
Received: 4 July 2012 / Revised: 16 July 2012 / Accepted: 17 July 2012 / Published: 23 July 2012
(This article belongs to the Section Natural Products Chemistry)
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Abstract

Obesity is a global health problem. It is also known to be a risk factor for the development of metabolic disorders, type 2 diabetes, systemic hypertension, cardiovascular disease, dyslipidemia, and atherosclerosis. In this study, we elucidated that Buddleja officinalis Maximowicz extract significantly inhibited lipid accumulation during 3T3-L1 adipocyte differentiation. Furthermore, Buddleja officinalis Maximowicz extract reduced the body weight gain induced through feeding a high-fat diet to C57BL/6 mice. The treatment of Buddleja officinalis Maximowicz extract significantly reduced the adipose tissue weight to 2.7/100 g of body weight in high-fat mice. When their adipose tissue morphology was investigated for histochemical staining, the distribution of cell size in the high-fat diet groups was hypertrophied compared with those from Buddleja officinalis Maximowicz extract-treated mice. In addition, in Buddleja officinalis Maximowicz extract-treated mice, a significant reduction of serum triglyceride and T-cholesterol was observed at to 21% and 17%, respectively. The discovery of bioactive compounds from diet or dietary supplementation is one of possible ways to control obesity and to prevent or reduce the risks of various obesity-related diseases. These results support that Buddleja officinalis Maximowicz extract is expected to create the therapeutic interest with respect to the treatment of obesity. View Full-Text
Keywords: anti-obesity; lipid inhibition; adipocyte differentiation; Buddleja officinalis Maximowicz extract anti-obesity; lipid inhibition; adipocyte differentiation; Buddleja officinalis Maximowicz extract
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Roh, C.; Park, M.-K.; Shin, H.-J.; Jung, U.; Kim, J.-K. Buddleja officinalis Maximowicz Extract Inhibits Lipid Accumulation on Adipocyte Differentiation in 3T3-L1 Cells and High-Fat Mice. Molecules 2012, 17, 8687-8695.

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