Next Article in Journal
Assessment of Worldwide Genetic Diversity of Siberian Wild Rye (Elymus sibiricus L.) Germplasm Based on Gliadin Analysis
Previous Article in Journal
Adsorption Behavior of Fe(II) and Fe(III) Ions on Thiourea Cross-Linked Chitosan with Fe(III) as Template
Open AccessReview

Honey: A Novel Antioxidant

Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
*
Author to whom correspondence should be addressed.
Molecules 2012, 17(4), 4400-4423; https://doi.org/10.3390/molecules17044400
Received: 25 February 2012 / Revised: 30 March 2012 / Accepted: 1 April 2012 / Published: 12 April 2012
The global prevalence of chronic diseases such as diabetes mellitus, hypertension, atherosclerosis, cancer and Alzheimer's disease is on the rise. These diseases, which constitute the major causes of death globally, are associated with oxidative stress. Oxidative stress is defined as an “imbalance between oxidants and antioxidants in favor of the oxidants, potentially leading to damage”. Individuals with chronic diseases are more susceptible to oxidative stress and damage because they have elevated levels of oxidants and/or reduced antioxidants. This, therefore, necessitates supplementation with antioxidants so as to delay, prevent or remove oxidative damage. Honey is a natural substance with many medicinal effects such as antibacterial, hepatoprotective, hypoglycemic, reproductive, antihypertensive and antioxidant effects. This review presents findings that indicate honey may ameliorate oxidative stress in the gastrointestinal tract (GIT), liver, pancreas, kidney, reproductive organs and plasma/serum. Besides, the review highlights data that demonstrate the synergistic antioxidant effect of honey and antidiabetic drugs in the pancreas, kidney and serum of diabetic rats. These data suggest that honey, administered alone or in combination with conventional therapy, might be a novel antioxidant in the management of chronic diseases commonly associated with oxidative stress. In view of the fact that the majority of these data emanate from animal studies, there is an urgent need to investigate this antioxidant effect of honey in human subjects with chronic or degenerative diseases. View Full-Text
Keywords: honey; antioxidant; oxidative stress; chronic diseases, kidney; pancreas; liver; plasma; testis honey; antioxidant; oxidative stress; chronic diseases, kidney; pancreas; liver; plasma; testis
Show Figures

Figure 1

MDPI and ACS Style

Erejuwa, O.O.; Sulaiman, S.A.; Ab Wahab, M.S. Honey: A Novel Antioxidant. Molecules 2012, 17, 4400-4423.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop