Bioactive Phenolic Amides from Celtis africana
Abstract
:1. Introduction
2. Results and Discussion
2.1. Structure Elucidation and Biological Assay of Compounds 1–3
Compounds | DPPH Scavenging Activity IC50a [μM] |
---|---|
1 | 62.0 ± 0.15 |
2 | 33.2 ± 0.14 |
3 | 26.3 ± 0.32 |
BHAb | 44.3 ± 0.09 |
Group (3 rats in each) | Treatment10 mg/kg | Edema Volume(Vc = Vf − V0) | Percent Inhibition(%) |
---|---|---|---|
1 | Cage-1 control | 0 | |
2 | Diclofenic Sodium | 0.22 ± 0.05 | 57.6 |
3 | 1 | 0.26 ± 0.24 | 48.3 |
4 | 2 | 0.35 ± 0.22 | 32.6 |
5 | 3 | 0.28 ± 0.11 | 25.5 |
Compounds | AChE IC50a [μM] |
---|---|
1 | 98.3 ± 0.21 |
2 | 86.0 ± 0.34 |
3 | 84.3 ± 0.32 |
Galanthamine | 32.3 ± 2.3 |
3. Experimental
3.1. General
3.2. Plant Material
3.3. Extraction and Isolation
3.4. Biological Bioassay
3.4.1. Antioxidant Assay
3.4.2. In Vivo Anti-Inflammatory Assay
3.4.3.In Vitro Acetylcholinesterase Inhibition Assay
3.4.4. Estimation of IC50 Values
3.5. Spectral Data
4. Conclusions
Acknowledgements
Conflict of Interest
- Samples Availability: Not available.
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Al-Taweel, A.M.; Perveen, S.; El-Shafae, A.M.; Fawzy, G.A.; Malik, A.; Afza, N.; Iqbal, L.; Latif, M. Bioactive Phenolic Amides from Celtis africana. Molecules 2012, 17, 2675-2682. https://doi.org/10.3390/molecules17032675
Al-Taweel AM, Perveen S, El-Shafae AM, Fawzy GA, Malik A, Afza N, Iqbal L, Latif M. Bioactive Phenolic Amides from Celtis africana. Molecules. 2012; 17(3):2675-2682. https://doi.org/10.3390/molecules17032675
Chicago/Turabian StyleAl-Taweel, Areej Mohammad, Shagufta Perveen, Azza Muhammed El-Shafae, Ghada Ahmed Fawzy, Abdul Malik, Nighat Afza, Lubna Iqbal, and Mehreen Latif. 2012. "Bioactive Phenolic Amides from Celtis africana" Molecules 17, no. 3: 2675-2682. https://doi.org/10.3390/molecules17032675