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Molecules 2012, 17(2), 2049-2057;

Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides

Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Coyoacan C.P. 04960, D.F.A.P. 23-181, Mexico
Author to whom correspondence should be addressed.
Received: 13 February 2012 / Revised: 13 February 2012 / Accepted: 14 February 2012 / Published: 20 February 2012
(This article belongs to the Section Natural Products Chemistry)
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In the present work we describe the structure and anti-inflammatory activity of a new compound, kramecyne, isolated from a methanol extract of Krameria cytisoides (Krameriaceae). The structure of kramecyne was determined by IR, NMR, MS, and elemental analysis, which indicated that the structure corresponded to a hexamer of cyclic peroxide monomers. This compound exhibited good anti-inflammatory activity in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema (51.8 ± 6.9% inhibition) and carrageenan-induced rat paw edema models at doses of 50 mg/kg. The compound significantly reduced edema to 63.1% after 1.0 h, and the effect was unchanged for 5 h. Kramecyne did not present acute toxicity, even at doses of 5,000 mg/kg. View Full-Text
Keywords: anti-inflammatory activity; Krameria; peroxide; polymer; kramecyne anti-inflammatory activity; Krameria; peroxide; polymer; kramecyne

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Pérez-Gutiérrez, S.; Sánchez-Mendoza, E.; Martínez-González, D.; Zavala-Sánchez, M.A.; Pérez-González, C. Kramecyne — A New Anti-inflammatory Compound Isolated from Krameria cytisoides. Molecules 2012, 17, 2049-2057.

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