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Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives

Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt
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Molecules 2012, 17(12), 14625-14636; https://doi.org/10.3390/molecules171214625
Received: 16 October 2012 / Revised: 23 November 2012 / Accepted: 26 November 2012 / Published: 10 December 2012
New series of 1,3,4-thiadiazoles have been prepared via reaction of 1,3,4-thiadiazolenaminones 1 with N-phenyl 2-oxopropanehydrazonoyl chloride (2) in dioxane in the presence of triethylamine. Also, some new heterocycles incorporating 1,3,4-thiadiazole ring were obtained by reaction of 1,3,4-thiadiazolenaminones 1 with nitrogen-nucleophiles like hydrazine hydrate, 3-amino-1,2,4-triazole and 2-aminobenzimidazole. The structure of the new products was established based on elemental and spectral analysis. The relation between the structure of the products and their activity towards some microorganisms was studied and promising results were obtained. View Full-Text
Keywords: antimicrobial activity; enaminone; 1,3,4-thiadiazole; hydrazonoyl halides antimicrobial activity; enaminone; 1,3,4-thiadiazole; hydrazonoyl halides
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Farghaly, T.A.; Abdallah, M.A.; Aziz, M.R.A. Synthesis and Antimicrobial Activity of Some New 1,3,4-Thiadiazole Derivatives. Molecules 2012, 17, 14625-14636.

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