Next Article in Journal
Preparation of Dispersed Particle Gel (DPG) through a Simple High Speed Shearing Method
Previous Article in Journal
Efficacy of Carbazole Alkaloids, Essential Oil and Extract of Murraya koenigii in Enhancing Subcutaneous Wound Healing in Rats
Open AccessArticle

Multi-Component One-Pot Synthesis and Antimicrobial Activities of 3-Methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydro-pyrazolo[5,4-b]pyrimidino[5,4-e]pyridine-5-one and Related Derivatives

Department of Chemistry, Faculty of Science, Assiut University, Assiut 71516, Egypt
*
Author to whom correspondence should be addressed.
Molecules 2012, 17(12), 14464-14483; https://doi.org/10.3390/molecules171214464
Received: 24 October 2012 / Revised: 25 November 2012 / Accepted: 27 November 2012 / Published: 6 December 2012
(This article belongs to the Section Organic Chemistry)
The synthesis of 3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydropyrazolo[5,4-b] pyrimidino[5,4-e]pyridine-5-one (6) was achieved by two different one-pot multi-component synthesis (one-pot three-component and one-pot four component synthesis). Mono and dialkylation of 6 under different conditions gave compounds 711. The hydrazine 12 produced from reaction of 9 with N2H4 was subjected to reactions with some aromatic aldehydes, ethyl acetoacetate, acetyl acetone, ethyl cyanoacetate and triethyl orthoformate to give 1317, respectively. Compound 12 upon reaction with CS2, nitrous acid, benzoin, chloroacetone and phenacyl bromide gave 18,20,21,22. Alkylation of 18 with ethyl iodide, ethyl chloroacetate and phenacyl bromide gave 19ac. The antibacterial and antifungal activities of selected derivatives were evaluated. View Full-Text
Keywords: one-pot reactions; pyrazolo[5,4-b]pyrimidino[5,4-e]pyridines; synthesis; anti-microbial activity one-pot reactions; pyrazolo[5,4-b]pyrimidino[5,4-e]pyridines; synthesis; anti-microbial activity
Show Figures

Scheme 1

MDPI and ACS Style

El-Emary, T.I.; El-Mohsen, S.A.A. Multi-Component One-Pot Synthesis and Antimicrobial Activities of 3-Methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydro-pyrazolo[5,4-b]pyrimidino[5,4-e]pyridine-5-one and Related Derivatives. Molecules 2012, 17, 14464-14483.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Search more from Scilit
 
Search
Back to TopTop