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Open AccessArticle

Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarpus orientalis From Al Ain and Oman

1
Department of Biology, Faculty of Science, U.A.E. University, Al-Ain, P.O. Box 17551, UAE
2
National Organization of Drug Control and Research, 6 Abu Hazem St., Giza, 12613, Egypt
*
Author to whom correspondence should be addressed.
Molecules 2012, 17(11), 12521-12532; https://doi.org/10.3390/molecules171112521
Received: 5 July 2012 / Revised: 3 September 2012 / Accepted: 20 September 2012 / Published: 24 October 2012
(This article belongs to the Section Natural Products Chemistry)
Acridocarpus orientalis (AO) is a traditional medicinal plant used for treatment of inflammatory diseases that may have potential in cancer treatment. In the present study, the aqueous ethanolic crude extract of Acridocarpus aerial parts obtained from Al Ain and Oman were evaluated for their antioxidant capability, polyphenolic content, anti-lipoxygenase and anti-histone deacetylase (HDAC) properties. The total antioxidant capacity was estimated by the FRAP, DPPH, ABTS and b-carotene bleaching assays. Acridocarpus-Al Ain exhibited the highest polyphenolic content (184.24 mg gallic acid/g) and the best antioxidant activity (1.1, 1.04, 1.14 mmol ascorbic acid equivalent/g in the FRAP, ABTS and DPPH assays, respectively). Additionally, the same extract showed significant anti-inflammatory properties via lipoxygenase (LOX) inhibitory activity (IC50 = 50.58 µg/mL). Acridocarpus-Al Ain also showed the strongest histone deacetylase (HDACs) inhibitory activity (IC50 = 93.28 µg/mL). The results reported here suggest that there was a significant influence of location and the plant may be considered a good source of compounds with antioxidant, anti-LOX and HDAC properties for therapeutic, nutraceutical and functional food applications. View Full-Text
Keywords: Acridocarpus orientalis; total phenol; antioxidant; anti-lipoxygenase; anti-histone deacetylase activity Acridocarpus orientalis; total phenol; antioxidant; anti-lipoxygenase; anti-histone deacetylase activity
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MDPI and ACS Style

Ksiksi, T.; Hamza, A.A. Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarpus orientalis From Al Ain and Oman. Molecules 2012, 17, 12521-12532. https://doi.org/10.3390/molecules171112521

AMA Style

Ksiksi T, Hamza AA. Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarpus orientalis From Al Ain and Oman. Molecules. 2012; 17(11):12521-12532. https://doi.org/10.3390/molecules171112521

Chicago/Turabian Style

Ksiksi, Taoufik; Hamza, Alaaeldin A. 2012. "Antioxidant, Lipoxygenase and Histone Deacetylase Inhibitory Activities of Acridocarpus orientalis From Al Ain and Oman" Molecules 17, no. 11: 12521-12532. https://doi.org/10.3390/molecules171112521

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