Next Article in Journal
Synthesis of cis- and trans-3-Aminocyclohexanols by Reduction of β-Enaminoketones
Previous Article in Journal
Like a Bolt from the Blue: Phthalocyanines in Biomedical Optics
Article Menu

Export Article

Open AccessCommunication
Molecules 2012, 17(1), 145-150;

The Biological Response of Spermidine Induced by Ionization Radiation

Radiation Research Division for Biotechnology, Advanced Radiation Technology Institute (ARTI), Korea Atomic Energy Research Institute (KAERI), 1266, Sinjeong-dong, Jeongeup, Jeonbuk 580-185, Korea
Author to whom correspondence should be addressed.
Received: 14 November 2011 / Revised: 20 December 2011 / Accepted: 21 December 2011 / Published: 23 December 2011
(This article belongs to the Section Molecular Diversity)
Full-Text   |   PDF [266 KB, uploaded 18 June 2014]   |  


Globally, there are concerns over the risks associated with radiation exposure, so it is important to understand the biological effects of radiation exposure. Driven by the need to detect the presence of radiation exposure, biomarkers to monitor potential exposure after radiological accidents can be developed and would be extremely valuable for biological response. In this study, the behavior of spermidine as a biomarker was investigated in a C57BL/6 mouse model exposed to an acute whole-body sublethal dose of 6 Gy. The spermidine content values in serum increased for up to two days after 6 Gy irradiation. However, the enhanced spermidine content observed on day +3 in irradiated mice returned to normal levels on the subsequent five days. The result indicates that spermidine can be used as a biomarker of biological response to radiation exposure. View Full-Text
Keywords: ionizing radiation; metabolomics; polyamines; biological response ionizing radiation; metabolomics; polyamines; biological response

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Roh, C.; Yu, D.-K.; Kim, I.; Jo, S.K. The Biological Response of Spermidine Induced by Ionization Radiation. Molecules 2012, 17, 145-150.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top