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Molecules 2011, 16(9), 8053-8061;

A Short Synthesis of Bisabolane Sesquiterpenes

College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China
Key Laboratory of Protection and Utilization of Biological Resources in Tarim Basin, Talimu University, Alaer, Xinjiang 843300, China
Author to whom correspondence should be addressed.
Received: 31 August 2011 / Revised: 4 September 2011 / Accepted: 14 September 2011 / Published: 19 September 2011
(This article belongs to the Special Issue Terpenoids)
PDF [436 KB, uploaded 18 June 2014]


A facile total synthesis of three members of the bisabolane sesquiterpene family, namely (±)-curcumene, (±)-xanthorrhizol and (±)-curcuhydroquinone had been achieved in high overall yield. The synthesis used bromobenzene derivatives as starting materials. The halogen-lithium exchange followed by addition of isoprenylacetone and reduction of the obtained carbinols are the key steps of the synthetic pathway. This synthetic approach provides a new route to the bisabolane sesquiterpenes.
Keywords: curcumene; xanthorrhizol; curcuhydroquinone; synthesis curcumene; xanthorrhizol; curcuhydroquinone; synthesis
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Du, Z.-T.; Zheng, S.; Chen, G.; Lv, D. A Short Synthesis of Bisabolane Sesquiterpenes. Molecules 2011, 16, 8053-8061.

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