Synthesis of Some Oxadiazole Derivatives as New Anticandidal Agents
Abstract
:1. Introduction
2. Results and Discussion
Compound | R | Yield (%) | M.p. (°C) | Molecular formula | Molecular weight |
---|---|---|---|---|---|
4a | H | 75 | 112-114 | C15H12N4O2S2 | 344 |
4b | p-Cl | 85 | 106-108 | C15H11ClN4O2S2 | 378,5 |
4c | p-NO2 | 95 | 145-149 | C15H11N5O4S2 | 389 |
4d | m-NO2 | 92 | 79-80 | C15H11N5O4S2 | 389 |
4e | m-Cl | 84 | 89-90 | C15H11ClN4O2S2 | 378,5 |
4f | 2,4-Cl | 88 | 75-77 | C15H10Cl2N4O2S2 | 413 |
4a | 4b | 4c | 4d | 4e | 4f | Ref. | |
---|---|---|---|---|---|---|---|
A | 0.015 | 0.015 | 0.06 | 0.125 | 0.015 | 0.03 | 0.007 |
B | 0.03 | 0.03 | 0.03 | 0.06 | 0.03 | 0.06 | 0.007 |
C | 0.03 | 0.125 | 0.06 | 0.06 | 0.125 | 0.06 | 0.003 |
D | 0.015 | 0.015 | 0.015 | 0.06 | 0.06 | 0.06 | 0.001 |
E | 0.007 | 0.03 | 0.015 | 0.125 | 0.03 | 0.015 | 0.001 |
F | 0.06 | 0.06 | 0.03 | 0.06 | 0.06 | 0.06 | 0.001 |
G | 0.06 | 0.06 | 0.06 | 0.125 | 0.06 | 0.06 | 0.001 |
H | 0.06 | 0.03 | 0.03 | 0.06 | 0.03 | 0.015 | 0.001 |
3. Experimental
3.1. General
3.2. General Procedure for Synthesis of the Compounds
3.3. Microbiology
3.3.1. Anticandidal Evaluation
3.3.2. Microbroth Dilution Assay
4. Conclusions
Conflict of Interest
- Samples Availability: Samples of the compounds 4a–f are available from the author.
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Kaplancikli, Z.A. Synthesis of Some Oxadiazole Derivatives as New Anticandidal Agents. Molecules 2011, 16, 7662-7671. https://doi.org/10.3390/molecules16097662
Kaplancikli ZA. Synthesis of Some Oxadiazole Derivatives as New Anticandidal Agents. Molecules. 2011; 16(9):7662-7671. https://doi.org/10.3390/molecules16097662
Chicago/Turabian StyleKaplancikli, Zafer Asim. 2011. "Synthesis of Some Oxadiazole Derivatives as New Anticandidal Agents" Molecules 16, no. 9: 7662-7671. https://doi.org/10.3390/molecules16097662