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Molecules 2011, 16(4), 2833-2845;

Synthesis and Herbicidal Activity of 5-(4-Hydroxybenzyl)-2-Thioxoimidazolidin-4-one Esters

Department of Applied Chemistry, China Agricultural University, Beijing 100193, China
State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China
Author to whom correspondence should be addressed.
Received: 28 February 2011 / Revised: 16 March 2011 / Accepted: 25 March 2011 / Published: 30 March 2011
(This article belongs to the Collection Bioactive Compounds)
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A series of novel 5-(4-hydroxybenzyl)-2-thioxoimidazolidin-4-one esters were synthesized under mild conditions by the reaction of 5-(4-hydroxybenzyl)-2-thioxoimidazolidin-4-one and carboxylic acids with DCC and DMAP as the promoters. Their structures were confirmed by 1H-NMR, IR, ESI-MS and elemental analysis. The preliminary bioassy results indicated that some of compounds exhibit good herbicidal activity against Zea mays, Triticum aestivum and Arabidopsis thaliana. The further greenhouse test showed that compounds 6-16 and 6-28 have 60%, 50% and 50% efficacy against Stellaria media, Echinochloa crus-galli and Setaria viridis at 1,000 g/ha, respectively. View Full-Text
Keywords: 5-(4-hydroxybenzyl)-2-thioxoimidazolidin-4-one esters; synthesis; herbicidal activity 5-(4-hydroxybenzyl)-2-thioxoimidazolidin-4-one esters; synthesis; herbicidal activity

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Han, J.; Wang, J.; Dong, H.; Lei, J.; Wang, M.; Fang, J. Synthesis and Herbicidal Activity of 5-(4-Hydroxybenzyl)-2-Thioxoimidazolidin-4-one Esters. Molecules 2011, 16, 2833-2845.

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