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Molecules 2011, 16(3), 2107-2118;

Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A)

Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Ex-Hacienda de la Concepción, Tilcuautla, 42080 Pachuca de Soto, Hgo, Mexico
Ezose Sciences Inc, Pine Brook, New Jersey 07058, USA
Parasitología Experimental, Instituto Nacional de Pediatría, Mexico, D.F. Mexico
Laboratorio de Virus y Cáncer, Unidad de Investigación Biomédica en Cáncer. Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México and Instituto Nacional de Cancerología, Secretaría de Salud, Mexico, D.F., Mexico
Facultad de Odontología, Universidad Nacional Autónoma de México (UNAM), México, D.F., Mexico
Instituto de Ciencias Básicas e Ingeniería, Universidad Autónoma del Estado de Hidalgo, Pachuca, Hidalgo, Mexico
Escuela Superior de Cómputo, Instituto Politécnico Nacional, México, D.F., Mexico
Author to whom correspondence should be addressed.
Received: 16 December 2010 / Revised: 25 February 2011 / Accepted: 28 February 2011 / Published: 2 March 2011
(This article belongs to the Section Molecular Diversity)
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Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines. View Full-Text
Keywords: lectins; tepary beans; cytotoxicity; tepary bean lectins lectins; tepary beans; cytotoxicity; tepary bean lectins

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Valadez-Vega, C.; Alvarez-Manilla, G.; Riverón-Negrete, L.; García-Carrancá, A.; Morales-González, J.A.; Zuñiga-Pérez, C.; Madrigal-Santillán, E.; Esquivel-Soto, J.; Esquivel-Chirino, C.; Villagómez-Ibarra, R.; Bautista, M.; Morales-González, Á. Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A). Molecules 2011, 16, 2107-2118.

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