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Open AccessReview
Molecules 2011, 16(10), 8515-8534;

Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010

Laboratory of Pharmaceutical Technology, Federal University of Paraiba, 58051-900, João Pessoa-PB, Brazil
Department of Chemistry, Federal University of Paraíba, 58059-900, João Pessoa-PB, Brazil
Author to whom correspondence should be addressed.
Received: 22 July 2011 / Revised: 7 September 2011 / Accepted: 26 September 2011 / Published: 11 October 2011
(This article belongs to the Special Issue Alkaloids: Novel Therapeutic Perspectives)
Full-Text   |   PDF [413 KB, uploaded 18 June 2014]


Many natural substances with proven anti-inflammatory activity have been isolated throughout the years. The aim of this review is to review naturally sourced alkaloids with anti-inflammatory effects reported from 2000 to 2010. The assays were conducted mostly in vivo, and carrageenan-induced pedal edema was the most used experimental model. Of the 49 alkaloids evaluated, 40 demonstrated anti-inflammatory activity. Of these the most studied type were the isoquinolines. This review was based on NAPRALERT data bank, Web of Science and Chemical Abstracts. In this review, 95 references are cited. View Full-Text
Keywords: alkaloids; anti-inflammatory activity; inflammation; experimental models; review alkaloids; anti-inflammatory activity; inflammation; experimental models; review
This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Souto, A.L.; Tavares, J.F.; da Silva, M.S.; Diniz, M.F.F.M.; de Athayde-Filho, P.F.; Barbosa Filho, J.M. Anti-Inflammatory Activity of Alkaloids: An Update from 2000 to 2010. Molecules 2011, 16, 8515-8534.

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