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Antimicrobial and Antioxidant Activities of the Root Bark Essential Oil of Periploca sepium and Its Main Component 2-Hydroxy-4-methoxybenzaldehyde

College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China
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Molecules 2010, 15(8), 5807-5817; https://doi.org/10.3390/molecules15085807
Received: 5 August 2010 / Revised: 16 August 2010 / Accepted: 23 August 2010 / Published: 24 August 2010
(This article belongs to the Special Issue Phenolics and Polyphenolics)
The root bark essential oil of Periploca sepium Bunge (Asclepiadaceae/ Apocynaceae) obtained by hydrodistillation was investigated by GC and GC-MS. 2-Hydroxy-4-methoxybenzaldehyde was found to be the main component (78.8% of the total) among 17 identified compounds. 2-Hydroxy-4-methoxybenzaldehyde was separated and purified by preparative thin layer chromatography, and was further identified by means of physicochemical and spectrometric analysis. Both the essential oil and 2-hydroxy-4-methoxybenzaldehyde exhibited antimicrobial activities on all test bacteria and fungi, with MBC/MFC values ranging from 125 μg/mL to 300 μg/mL, MIC values from 80 μg/mL to 300 μg/mL, and IC50 values from 63.29 μg/mL to 167.30 μg/mL. They also showed moderate antioxidant activity in the DPPH free radical scavenging, β-carotene bleaching and ferrozine-ferrous ions assays. The results indicated that the major portion of these antimicrobial and antioxidant activities was due to the presence of 2-hydroxy-4-methoxy-benzaldehyde in the oil, which could potentially be developed as an antimicrobial and antioxidant agent in the future. View Full-Text
Keywords: Asclepiadaceae; Apocynaceae; Periploca sepium; essential oil; 2-hydroxy-4-methoxybenzaldehyde; antimicrobial activity; antioxidant activity Asclepiadaceae; Apocynaceae; Periploca sepium; essential oil; 2-hydroxy-4-methoxybenzaldehyde; antimicrobial activity; antioxidant activity
MDPI and ACS Style

Wang, J.; Liu, H.; Zhao, J.; Gao, H.; Zhou, L.; Liu, Z.; Chen, Y.; Sui, P. Antimicrobial and Antioxidant Activities of the Root Bark Essential Oil of Periploca sepium and Its Main Component 2-Hydroxy-4-methoxybenzaldehyde. Molecules 2010, 15, 5807-5817.

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