Next Article in Journal
Natural Carotenoids as Nanomaterial Precursors for Molecular Photovoltaics: A Computational DFT Study
Previous Article in Journal
Antioxidant Properties of European Cranberrybush Fruit (Viburnum opulus var. edule)
Open AccessArticle

In Vitro Antioxidant Activity and Hepatoprotective Effects of Lentinula edodes against Paracetamol-Induced Hepatotoxicity

1
Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia
2
Department of Biotechnology, Faculty of Applied Sciences, AIMST University, Jalan Bedong-Semeling, Batu 3 ½, Bukit Air Nasi, Bedong 08100, Kedah, Malaysia
3
School of Biological Sciences, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia
4
Centre for Drug Research, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia
5
School of Biotechnology, Madurai Kamaraj University, Palkalai Nagar, Madurai, India
*
Author to whom correspondence should be addressed.
Molecules 2010, 15(6), 4478-4489; https://doi.org/10.3390/molecules15064478
Received: 6 May 2010 / Revised: 9 June 2010 / Accepted: 10 June 2010 / Published: 23 June 2010
Background: The objective of this study was to investigate the antioxidant and hepatoprotective effects of methanolic extracts of L. edodes and the determination of their total phenolics content. Results: The amount of total phenolics was estimated to be 70.83 mg Gallic Acid Equivalent (GAE) per gram of dry extract. The antioxidant activity of the L. edodes extract was 39.0% at a concentration of 1 mg/mL and was also concentration dependant, with an EC50 value of 4.4 mg/mL. Different groups of animals (Wister albino mice) were administered paracetamol (1 g/kg, p.o.). L. edodes extract at a dose of 200 mg/kg was administered to the paracetamol treated mice for seven days. The effects of L. edodes extract on serum transaminases (SGOT, SGPT), alkaline phosphatase (ALP) and bilirubin were measured in the paracetamol-induced hepatotoxic mice. L. edodes extract produced significant (p < 0.05) hepatoprotective effects by decreasing the activity of serum enzymes and bilirubin. Conclusions: From these results, it was suggested that L. edodes extract could perhaps protect liver cells from paracetamol-induced liver damage by its antioxidative effect on hepatocytes, hence diminishing or eliminating the harmful effects of toxic metabolites of paracetamol. View Full-Text
Keywords: Lentinula edodes; hepatoprotective activity; antioxidant activity; liver marker enzymes Lentinula edodes; hepatoprotective activity; antioxidant activity; liver marker enzymes
Show Figures

Figure 1

MDPI and ACS Style

Sasidharan, S.; Aravindran, S.; Latha, L.Y.; Vijenthi, R.; Saravanan, D.; Amutha, S. In Vitro Antioxidant Activity and Hepatoprotective Effects of Lentinula edodes against Paracetamol-Induced Hepatotoxicity. Molecules 2010, 15, 4478-4489.

Show more citation formats Show less citations formats

Article Access Map by Country/Region

1
Only visits after 24 November 2015 are recorded.
Back to TopTop