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Molecules 2010, 15(6), 4261-4266;

Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid

School of Pharmacy, Nanjing Medical University, Nanjing 210029, China
Nanjing Children’s hospital, Nanjing Medical University, Nanjing 210008, China
Author to whom correspondence should be addressed.
Received: 9 April 2010 / Revised: 13 May 2010 / Accepted: 9 June 2010 / Published: 11 June 2010
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This paper reports a novel synthesis of bosutinib starting from 3-methoxy-4-hydroxybenzoic acid. The process starts with esterification of the starting material, followed by alkylation, nitration, reduction, cyclization, chlorination and two successive amination reactions. The intermediates and target molecule were characterized by 1H-NMR, 13C-NMR, MS and the purities of all the compounds were determined by HPLC. View Full-Text
Keywords: bosutinib; protein kinase inhibitors; 3-methoxy-4-hydroxybenzoic acid bosutinib; protein kinase inhibitors; 3-methoxy-4-hydroxybenzoic acid

Scheme 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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MDPI and ACS Style

Yin, X.J.; Xu, G.H.; Sun, X.; Peng, Y.; Ji, X.; Jiang, K.; Li, F. Synthesis of Bosutinib from 3-Methoxy-4-hydroxybenzoic Acid. Molecules 2010, 15, 4261-4266.

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