Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies
Abstract
:1. Introduction
2. The History of Artemisinin
3. Physical and Chemical Properties of Artemisinin
4. Artemisinins and Iron
5. The Structure-Efficacy Relationship of Artemisinins and Other Endoperoxidic Antimalarials
6. Mechanistic Insights from Chemistry Studies and Proposed Biological Models
6.1. PfATP6 as the target
6.2. Heme as the activator and target
6.3. Mitochondria as the target
7. Mutations Affecting Artemisinin Resistance
8. Conclusions
Acknowledgements
References
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Li, J.; Zhou, B. Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies. Molecules 2010, 15, 1378-1397. https://doi.org/10.3390/molecules15031378
Li J, Zhou B. Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies. Molecules. 2010; 15(3):1378-1397. https://doi.org/10.3390/molecules15031378
Chicago/Turabian StyleLi, Jian, and Bing Zhou. 2010. "Biological Actions of Artemisinin: Insights from Medicinal Chemistry Studies" Molecules 15, no. 3: 1378-1397. https://doi.org/10.3390/molecules15031378