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A Novel Benzo[f][1,7]Naphthyridine Produced by Streptomyces Albogriseolus from Mangrove Sediments

by Xiao-Ling Li 1,3,†, Min-Juan Xu 2,†, Yi-Lei Zhao 1 and Jun Xu 1,*
1
Key Laboratory of MOE for Microbial metabolism and School of Life Science & Biotechnology, State Key Laboratory of Ocean Engineering, Shanghai JiaoTong University, Shanghai 200240, China
2
Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China
3
Key Laboratory of Marine Biogenetic Resources, the Third Institute of Oceanography SOA, Xiamen, Fujian 361005, China
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2010, 15(12), 9298-9307; https://doi.org/10.3390/molecules15129298
Received: 24 October 2010 / Revised: 30 November 2010 / Accepted: 7 December 2010 / Published: 15 December 2010
(This article belongs to the Section Natural Products Chemistry)
Mangrove Streptomyces represent a rich source of novel bioactive compounds in medicinal research. A novel alkaloid, named 1-N-methyl-3-methylamino-[N-butanoic acid-3¢-(9¢-methyl-8¢-propen-7¢-one)-amide]-benzo[f][1,7]naphthyridine-2-one (1) was isolated from Streptomyces albogriseolus originating from mangrove sediments. The structure of compound 1 was elucidated by extensive spectroscopic data analyses and verified by the 13C-NMR calculation at the B3LYP/6-311+G(2d,p) level of theory. View Full-Text
Keywords: Streptomyces albogriseolus; mangrove; benzo[f][1,7]naphthyridine Streptomyces albogriseolus; mangrove; benzo[f][1,7]naphthyridine
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Li, X.-L.; Xu, M.-J.; Zhao, Y.-L.; Xu, J. A Novel Benzo[f][1,7]Naphthyridine Produced by Streptomyces Albogriseolus from Mangrove Sediments. Molecules 2010, 15, 9298-9307.

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