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A Novel Benzo[f][1,7]Naphthyridine Produced by Streptomyces Albogriseolus from Mangrove Sediments

by Xiao-Ling Li 1,3,†, Min-Juan Xu 2,†, Yi-Lei Zhao 1 and Jun Xu 1,*
Key Laboratory of MOE for Microbial metabolism and School of Life Science & Biotechnology, State Key Laboratory of Ocean Engineering, Shanghai JiaoTong University, Shanghai 200240, China
Key Laboratory of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China
Key Laboratory of Marine Biogenetic Resources, the Third Institute of Oceanography SOA, Xiamen, Fujian 361005, China
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Molecules 2010, 15(12), 9298-9307;
Received: 24 October 2010 / Revised: 30 November 2010 / Accepted: 7 December 2010 / Published: 15 December 2010
(This article belongs to the Section Natural Products Chemistry)
Mangrove Streptomyces represent a rich source of novel bioactive compounds in medicinal research. A novel alkaloid, named 1-N-methyl-3-methylamino-[N-butanoic acid-3¢-(9¢-methyl-8¢-propen-7¢-one)-amide]-benzo[f][1,7]naphthyridine-2-one (1) was isolated from Streptomyces albogriseolus originating from mangrove sediments. The structure of compound 1 was elucidated by extensive spectroscopic data analyses and verified by the 13C-NMR calculation at the B3LYP/6-311+G(2d,p) level of theory. View Full-Text
Keywords: Streptomyces albogriseolus; mangrove; benzo[f][1,7]naphthyridine Streptomyces albogriseolus; mangrove; benzo[f][1,7]naphthyridine
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Li, X.-L.; Xu, M.-J.; Zhao, Y.-L.; Xu, J. A Novel Benzo[f][1,7]Naphthyridine Produced by Streptomyces Albogriseolus from Mangrove Sediments. Molecules 2010, 15, 9298-9307.

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