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Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction

Department of Natural Products Chemistry, Pharmaceutical School, China Medical University, Shenyang 110001, China
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Molecules 2010, 15(11), 8501-8506; https://doi.org/10.3390/molecules15118501
Received: 9 October 2010 / Revised: 14 November 2010 / Accepted: 14 November 2010 / Published: 22 November 2010
In the course of synthesizing 3-demethyltylophorine (1) by Lewis acid catalyzed intramolecular Friedel-Crafts reaction starting from N-(3-hydroxy-2,6,7-trimethoxy-phenanthr-9-ylmethyl)-2-chloromethylpyrrolidine, two chlorinated phenanthrene derivatives N-(4,10-dichloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (4) and N-(4-chloro-3-hydroxy-2,6,7-trimethoxyphenanthr-9-ylmethyl)-2-chloromethylpyrrolidine (5) were obtained. The structures of these compounds were determined by spectroscopic analysis. View Full-Text
Keywords: phenanthroindolizidine; antitumor; Friedel-Crafts reaction phenanthroindolizidine; antitumor; Friedel-Crafts reaction
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Li, S.; Han, L.; Liu, J.; Hu, Y.; Zheng, D.; Fu, Y.; Huang, X. Synthesis of Seco-Chlorinated Derivatives of Phenanthroindolizidine Precursors via Friedel-Crafts Reaction. Molecules 2010, 15, 8501-8506.

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