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Correction published on 10 November 2010, see Molecules 2010, 15(11), 8143.

Open AccessArticle

Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia
Molecules 2010, 15(10), 7016-7034;
Received: 25 September 2010 / Revised: 29 September 2010 / Accepted: 8 October 2010 / Published: 12 October 2010
PDF [177 KB, uploaded 18 June 2014]


This paper reports the synthesis of phenyl-substituted 2-alkoxy(methylsulfanyl)-1,2,4-triazolo[1,5-a]quinazolines starting from N-cyanoimidocarbonates and substituted hydrazinobenzoic acids as building blocks. Thionation or chlorination of the inherent lactam moiety in the target compounds followed by treatment with multifunctional nucleophiles provided access to a variety of derivatives. View Full-Text
Keywords: triazolo[1,5-a]quinazolines; thionation; alkylation; chlorination; tetracyclic systems triazolo[1,5-a]quinazolines; thionation; alkylation; chlorination; tetracyclic systems

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Al-Salahi, R.A. Synthesis and Reactivity of [1,2,4]Triazolo-annelated Quinazolines. Molecules 2010, 15, 7016-7034.

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