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Molecules 2009, 14(8), 2947-2958;

Antioxidant Activity of Some Plant Extracts Towards Xanthine Oxidase, Lipoxygenase and Tyrosinase

College of Pharmacy, Taipei Medical University, 250 Wu Xin Street, Taipei 11031,Taiwan
Department of Medical Laboratory Science and Biotechnology, Yuanpei University, 306 Yuanpei St, Hsinchu 300, Taiwan
Author to whom correspondence should be addressed.
Received: 22 May 2009 / Revised: 9 July 2009 / Accepted: 22 July 2009 / Published: 10 August 2009
PDF [225 KB, uploaded 18 June 2014]


Natural products have the potential to be developed into new drugs for the treatment of various diseases. The aim of the present study was to screen the antioxidant activities of some common edible fruits, garden plants and medicinal plants indigenous to Taiwan. This was performed by assessing the activities of lipoxygenase, xanthine oxidase and tyrosinase following incubation with extracts from these plants. A further aim was to use HPLC-DAD and tyrosinase to chromatographically identify the antioxidative constituents obtained from an extract exhibiting strong antioxidative properties. The acetone extracts of 27 cultivated plant species from Taiwan were tested for antioxidant activities towards xanthine oxidase, tyrosinase and lipoxygenase using spectrophotometric assays. Koelreuteria henryi, Prunus campanulata, and Rhodiola rosea showed the highest xanthine oxidase inhibitory activities. Camellia sinensis, Rhodiola rosea, and Koelreuteria henryi exhibited good tyrosinase inhibitory activities and potent anti-lipoxygenase activities. As Koelreuteria henryi had notable significant inhibitory activities towards xanthine oxidase, tyrosinase, and lipoxygenase, it was further tested with tyrosinase and HPLC-DAD. The results from this part of the study revealed that the more powerful the antioxidant capability of the extracted component, the greater the decrease in peak height obtained after reacting with tyrosinase. Additional studies are warranted to further characterize the compounds responsible for the antioxidant properties of the examined extracts. View Full-Text
Keywords: HPLC-DAD; antioxidant; plant extracts; xanthine oxidase; tyrosinase; lipoxygenase HPLC-DAD; antioxidant; plant extracts; xanthine oxidase; tyrosinase; lipoxygenase

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Chen, C.-H.; Chan, H.-C.; Chu, Y.-T.; Ho, H.-Y.; Chen, P.-Y.; Lee, T.-H.; Lee, C.-K. Antioxidant Activity of Some Plant Extracts Towards Xanthine Oxidase, Lipoxygenase and Tyrosinase. Molecules 2009, 14, 2947-2958.

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