Next Article in Journal
Sonoelectrochemical Synthesis of Nanoparticles
Next Article in Special Issue
Oxidative Desulfurization of Fuel Oil by Pyridinium-Based Ionic Liquids
Previous Article in Journal
An Unsymmetrical Tetrathiafulvalene with a Fused 1,2,5-Thiadiazole Ring and Methylthio Groups
Previous Article in Special Issue
On the Chemical Stabilities of Ionic Liquids
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Molecules
Volume 14
Issue 10
10.3390/molecules14104275
molecules-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Communication

Preparation of (S)-1-Halo-2-octanols Using Ionic Liquids and Biocatalysts

by
Mireia Oromí-Farrús
1,
Jordi Eras
1,
Núria Sala
2,
Mercè Torres
2,* and
Ramon Canela
1,*
1
Chemistry Department, Lleida University, 25198-Lleida, Spain
2
Food Technology Department, Lleida University, 25198-Lleida, Spain
*
Authors to whom correspondence should be addressed.
Molecules 2009, 14(10), 4275-4283; https://doi.org/10.3390/molecules14104275
Submission received: 31 August 2009 / Revised: 26 September 2009 / Accepted: 16 October 2009 / Published: 23 October 2009
(This article belongs to the Collection Ionic Liquids)
Versions Notes

Abstract

Preparation of (S)-1-chloro-2-octanol and (S)-1-bromo-2-octanol was carried out by the enzymatic hydrolysis of halohydrin palmitates using biocatalysts. Halohydrin palmitates were prepared by various methods from palmitic acid and 1,2-octanediol. A tandem hydrolysis was carried out using lipases from Candida antarctica (Novozym® 435), Rhizomucor miehei (Lipozyme IM), and “resting cells” from a Rhizopus oryzae strain that was not mycotoxigenic. The influence of the enzyme and the reaction medium on the selective hydrolysis of isomeric mixtures of halohydrin esters is described. Novozym® 435 allowed preparation of (S)-1-chloro-2-octanol and (S)-1-bromo-2-octanol after 1–3 h of reaction at 40 °C in [BMIM][PF6].
Keywords: (S)-1-bromomethyl-1-heptanol; (S)-1-chloromethyl-1-heptanol; lipases; enzymatic resolution (S)-1-bromomethyl-1-heptanol; (S)-1-chloromethyl-1-heptanol; lipases; enzymatic resolution

Share and Cite

MDPI and ACS Style

Oromí-Farrús, M.; Eras, J.; Sala, N.; Torres, M.; Canela, R. Preparation of (S)-1-Halo-2-octanols Using Ionic Liquids and Biocatalysts. Molecules 2009, 14, 4275-4283. https://doi.org/10.3390/molecules14104275

AMA Style

Oromí-Farrús M, Eras J, Sala N, Torres M, Canela R. Preparation of (S)-1-Halo-2-octanols Using Ionic Liquids and Biocatalysts. Molecules. 2009; 14(10):4275-4283. https://doi.org/10.3390/molecules14104275

Chicago/Turabian Style

Oromí-Farrús, Mireia, Jordi Eras, Núria Sala, Mercè Torres, and Ramon Canela. 2009. "Preparation of (S)-1-Halo-2-octanols Using Ionic Liquids and Biocatalysts" Molecules 14, no. 10: 4275-4283. https://doi.org/10.3390/molecules14104275

APA Style

Oromí-Farrús, M., Eras, J., Sala, N., Torres, M., & Canela, R. (2009). Preparation of (S)-1-Halo-2-octanols Using Ionic Liquids and Biocatalysts. Molecules, 14(10), 4275-4283. https://doi.org/10.3390/molecules14104275

Article Metrics

Back to TopTop