Next Article in Journal
Synthesis of Novel Benzimidazolyl-substituted Acrylonitriles and Amidino-substituted Benzimidazo[1,2-a]Quinolines
Previous Article in Journal
Synthesis of Some New Anils: Part 1. Reaction of 2-Hydroxy-benzaldehyde and 2-Hydroxynaphthaldehyde with 2-Aminopyridene and 2-Aminopyrazine
Article Menu

Export Article

Open AccessArticle
Molecules 2007, 12(8), 1805-1816; https://doi.org/10.3390/12081805

A Study on 4-Acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones

1
Education Faculty, Kafkas University, 36100 Kars, Turkey
2
Department of Chemistry, Rize University, Rize, Turkey
3
Fatih Education Faculty, Karadeniz Technical University, 61335 Trabzon, Turkey
4
Gaziosmanpasa University, Dept. of Chemistry, Tokat, Turkey
5
Department of Chemistry, Karadeniz Technical University, 61100 Trabzon, Turkey
*
Author to whom correspondence should be addressed.
Received: 28 May 2007 / Revised: 2 August 2007 / Accepted: 2 August 2007 / Published: 13 August 2007
Full-Text   |   PDF [149 KB, uploaded 18 June 2014]   |  

Abstract

Five novel 3-alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) were synthesized by the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with phenylacetyl chloride and characterized by elemental analyses and IR, 1HNMR, 13C-NMR and UV spectral data. The newly synthesized compounds 2 were titrated potentiometrically with tetrabutylammonium hydroxide in four non-aqueous solvents such as isopropyl alcohol, tert-butyl alcohol, acetonitrile and N,N-dimethylformamide, and the half-neutralization potential values and the corresponding pKa values were determined for all cases. In addition, these new compounds and five recently reported 3-alkyl-4-(pmethoxybenzoylamino)- 4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were screened for their antioxidant activities. View Full-Text
Keywords: 4; 5-Dihydro-1H-1; 2; 4-triazol-5-ones; Acylation; Acidity; Potentiometric titrations; pKa; Antioxidant. 4; 5-Dihydro-1H-1; 2; 4-triazol-5-ones; Acylation; Acidity; Potentiometric titrations; pKa; Antioxidant.
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Alkan, M.; Yüksek, H.; İslamoğlu, F.; Bahçeci, S.; Calapoğlu, M.; Elmastaş, M.; Akşit, H.; Özdemir, M. A Study on 4-Acylamino-4,5-dihydro-1H-1,2,4-triazol-5-ones. Molecules 2007, 12, 1805-1816.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top