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Volume 15
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10.3390/e15125362
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Article

Ribozyme Activity of RNA Nonenzymatically Polymerized from 3′,5′-Cyclic GMP

by
Samanta Pino
1,
Giovanna Costanzo
2,
Alessandra Giorgi
3,
Jiří Šponer
4,
Judit E. Šponer
4 and
Ernesto Di Mauro
1,*
1
Fondazione "Istituto Pasteur-Fondazione Cenci-Bolognetti" c/o Dipartimento di Biologia e Biotecnologie "Charles Darwin", "Sapienza" Università di Roma, P.le Aldo Moro, 5, Rome 00185, Italy
2
Istituto di Biologia e Patologia Molecolari, CNR, P.le Aldo Moro, 5, Rome 00185, Italy
3
Dipartimento di Scienze Biochimiche, "Sapienza" Università di Roma, P.le Aldo Moro, 5, Rome 00185, Italy
4
Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, Brno 61265, Czech Republic
*
Author to whom correspondence should be addressed.
Entropy 2013, 15(12), 5362-5383; https://doi.org/10.3390/e15125362
Submission received: 13 September 2013 / Revised: 19 November 2013 / Accepted: 22 November 2013 / Published: 3 December 2013
(This article belongs to the Special Issue Entropy and RNA Structure, Folding and Mechanics)
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Abstract

3′,5′-Cyclic GMP spontaneously nonenzymatically polymerizes in a base-catalyzed reaction affording G oligonucleotides. When reacted with fully or partially sequence-complementary RNA (oligo C), the abiotically generated oligo G RNA displays a typical ribozyme activity consisting of terminal ligation accompanied by cleavage of an internal phosphate site of the donor oligonucleotide stem upon attack of the acceptor 3′ terminal OH. This reaction is dubbed Ligation following Intermolecular Cleavage (LIC). In a prebiotic perspective, the ability of oligo G polynucleotides to react with other sequences outlines a simple and possible evolutionary scenario based on the autocatalytic properties of RNA.
Keywords: RNA; RNA polymerization; RNA origin; ribozymes; origin of life RNA; RNA polymerization; RNA origin; ribozymes; origin of life
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MDPI and ACS Style

Pino, S.; Costanzo, G.; Giorgi, A.; Šponer, J.; Šponer, J.E.; Mauro, E.D. Ribozyme Activity of RNA Nonenzymatically Polymerized from 3′,5′-Cyclic GMP. Entropy 2013, 15, 5362-5383. https://doi.org/10.3390/e15125362

AMA Style

Pino S, Costanzo G, Giorgi A, Šponer J, Šponer JE, Mauro ED. Ribozyme Activity of RNA Nonenzymatically Polymerized from 3′,5′-Cyclic GMP. Entropy. 2013; 15(12):5362-5383. https://doi.org/10.3390/e15125362

Chicago/Turabian Style

Pino, Samanta, Giovanna Costanzo, Alessandra Giorgi, Jiří Šponer, Judit E. Šponer, and Ernesto Di Mauro. 2013. "Ribozyme Activity of RNA Nonenzymatically Polymerized from 3′,5′-Cyclic GMP" Entropy 15, no. 12: 5362-5383. https://doi.org/10.3390/e15125362

APA Style

Pino, S., Costanzo, G., Giorgi, A., Šponer, J., Šponer, J. E., & Mauro, E. D. (2013). Ribozyme Activity of RNA Nonenzymatically Polymerized from 3′,5′-Cyclic GMP. Entropy, 15(12), 5362-5383. https://doi.org/10.3390/e15125362

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