Topic Editors

Centre for Oral Immunobiology and Regenerative Medicine, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
Prof. Dr. Dipak Sapkota
Department of Oral Biology, University of Oslo, 0372 Oslo, Norwa
Dr. Tami Yap
Melbourne Dental School, Melbourne, Australia

Sustainable Point-of-Care Diagnostics for Early Oral Cancer Detection

Abstract submission deadline
30 June 2026
Manuscript submission deadline
30 August 2026
Viewed by
827

Topic Information

Dear Colleagues,

The increasing trends in global burden of oral cancer, particularly in low- and middle-income countries, underscores the urgent need for fast, sustainable, and cost-effective diagnostic solutions that can be deployed at the point of care (POC) to identify and treat patients rapidly with minimal intervention.

This research topic invites interdisciplinary contributions focused on biomarkers with clinical translational potential for early oral cancer detection, emphasizing accessibility for underserved and lower socioeconomic populations. We encourage studies that explore non-invasive (e.g., saliva, brush cytology, imaging, etc.), or minimally invasive (e.g., blood, needle aspiration, curette/punch biopsies, etc.) sampling methods for biomarkers that can be detected cost-effectively using user-friendly and robust platforms. Preference is given to biomarkers that minimize reliance on artificial intelligence (AI), positioning it as an optional enhancer rather than a core requirement to mitigate against overdependence on complex computational infrastructure, ensure diagnostic resilience in low-resource settings, and promote broader adoption in contexts whereby digital literacy, data privacy, or technological access may be limited. Instead, this topic advocates for the repurposing of existing technologies and the reinvestigation of previously overlooked or underutilized biomarkers through new scientific and contextual lenses. Sustainability is a key pillar of this topic, encompassing not only environmental considerations (e.g., biodegradable materials, low-energy devices, miniaturisation) but also long-term affordability and ease of integration into existing healthcare infrastructures.

We welcome research that bridges molecular biology, clinical chemistry, biosensing, engineering, and implementation science to create diagnostics that are not only scientifically rigorous but also culturally and logistically adaptable. Studies that include multicohort validations, community engagement, or health systems integration are particularly encouraged. By fostering innovation grounded in equity and pragmatism, this topic aims to catalyse the development of POC tools that democratize oral cancer detection and ultimately reduce global health disparities. We look forward to receiving contributions.

Prof. Dr. Muy-Teck Teh
Prof. Dr. Dipak Sapkota
Dr. Tami Yap
Topic Editors

Keywords

  • point-of-care diagnostics
  • early oral cancer detection
  • non-invasive
  • minimally invasive
  • cancer biomarkers
  • diagnostic imaging
  • translational research
  • cost-effective diagnostics
  • cancer screening
  • risk stratification

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomedicines
biomedicines
3.9 6.8 2013 17 Days CHF 2600 Submit
Cancers
cancers
4.4 8.8 2009 20.3 Days CHF 2900 Submit
Diagnostics
diagnostics
3.3 5.9 2011 21 Days CHF 2600 Submit
Journal of Clinical Medicine
jcm
2.9 5.2 2012 17.7 Days CHF 2600 Submit
Oral
oral
1.1 - 2021 23.3 Days CHF 1200 Submit

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Published Papers (1 paper)

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25 pages, 777 KB  
Systematic Review
Salivary MicroRNAs as Innovative Biomarkers for Diagnosis and Prediction of the Oral Potentially Malignant Disorders Transition Towards Oral Cancer: A Systematic Review
by Ciprian Osan, Ioana Berindan-Neagoe, Cristian Dinu, Gabriel Armencea, Simion Bran, Winfried Kretschmer, Grigore Baciut, Florin Onisor and Mihaela Baciut
J. Clin. Med. 2025, 14(22), 8128; https://doi.org/10.3390/jcm14228128 - 17 Nov 2025
Viewed by 534
Abstract
Background/Objectives: Oral potentially malignant diseases (OPMD) are a group of specific conditions characterized by a variable degree of progression to oral cancer. Although these lesions are generally easily recognizable, clinicians face a difficult challenge in predicting which lesions will undergo malignancy. This [...] Read more.
Background/Objectives: Oral potentially malignant diseases (OPMD) are a group of specific conditions characterized by a variable degree of progression to oral cancer. Although these lesions are generally easily recognizable, clinicians face a difficult challenge in predicting which lesions will undergo malignancy. This fact becomes more pressing when considering that early detection of OPMD significantly influences the survival toll. Our systematic review aims to evaluate current evidence of the mechanism through which salivary microRNAs are involved in OPMD and to study the possibility of using these molecules as a novel biomarker for predicting transition to oral cancer. Methods: A comprehensive search in PubMed, Google Academic, Cochrane and Scopus databases was performed, analyzing studies conducted between 2014 and 2025. The quality of studies was evaluated using Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2). Results: A total of 1046 articles were found; 76 articles were thoroughly examined, but only 33 articles were included in this systematic review. Salivary microRNAs, such as miR-21, miR-34a or miR-320a, were found to be dysregulated in OPMD samples compared to healthy and oral squamous cell carcinoma samples (OSCC), contributing to malignancy through gene expression alteration. Conclusions: Salivary microRNAs were found to be intricately involved in the malignant transformation of OPMD, potentially being promising biomarkers for early detection of oral cancer. Full article
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