Recent Advances in the Molecular Genetics of Lung Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: 30 May 2025 | Viewed by 490
Special Issue Editor
Special Issue Information
Dear Colleagues,
The upcoming Special Issue will review recent developments and future perspectives in the field of lung cancer genetics. It is well known that lung cancer is the most common cancer and the leading cause of cancer death worldwide. Although most lung cancers, particularly non-small-cell lung cancer (NSCLC), are caused by smoking, genetics plays an important role, as less than 20% of smokers will develop the disease, and non-smokers with a family history may also have an increased risk of developing the disease. The genetics of lung cancer is complex and includes alterations in oncogenes (EGFR, KRAS, ALK, and ROS1), tumor suppressor genes (p53, RB1, and CDKN2A) and other regulatory pathways. Chromosomal abnormalities, such as EML4-ALK fusion and EGFR amplification, as well as epigenetic changes, also play an important role in lung cancer. Because lung cancer is caused by a variety of genetic alterations, it is a dynamic and evolving field. Advances in the genetic understanding of lung cancer have revolutionized treatment strategies, particularly in immunotherapy for lung cancer driven by specific oncogenes, highlighting the need for comprehensive molecular profiling to fine-tune treatment choices.
In this Special Issue, original research articles and review articles are welcome. Research areas may include (but are not limited to) the following:
- The genetic landscape of lung cancer: oncogenes, tumor suppressor genes, chromosomal abnormalities, and gene expression profiling.
- Epigenetic alterations: DNA methylation and histone modifications.
- Genetic predisposition to lung cancer.
- Genetic testing.
- Environmental and lifestyle factors leading to lung cancer.
- Targeted therapies.
- Tumor microenvironment.
Dr. Iwona Ziółkowska-Suchanek
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- lung cancer
- molecular oncology
- genetics
- epigenetic alterations
- proteomics
- multi-omics approaches
- immunotherapy
- targeted therapy
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