Search Results (9)

As a type II ribosome-inactivating protein (RIP-II) toxin, Ricin has garnered widespread recognition due to its inherent qualities as an easily prepared and highly stable substance, posing serious implications as a potential chemical and biological terrorist threat. For the detection of ricin, traditional immunoassay technologies, including methods like peptide cleavage combined with liquid chromatography mass spectrometry (LC-MS) or the more commonly used enzyme-linked immunosorbent assay (ELISA), have offered reliable results. However, these techniques are unfortunately limited by the requirement of a complex sample pretreatment process, which can be time-consuming and labor-intensive. In an effort to overcome these limitations, a highly sensitive and selective method was introduced via metal element labeling combined with inductively coupled plasma mass spectrometry (ICP-MS) in this research. The method centered on designing and synthesizing a europium-labeled compound (DOTA-NHS-Eu) that specifically targets the amino groups (-NH₂) on ricin. The compound, coupled with the application of specific magnetic beads, achieved the specific enrichment and subsequent quantitative detection of ricin by ICP-MS, which is based on the amount of europium element present. The established method demonstrated high specificity for ricin recognition, with a signal response to bovine serum protein that was found to be less than 10% of that for ricin. Furthermore, the calibration curve created for the method (y = 81.543x + 674.02 (R² > 0.99)) for quantifying ricin in a concentration range of 1.0–100 μg/mL demonstrated good linearity. The method was further evidenced by the limit of detection and quantitation results of 0.1 and 1.89 μg/mL, respectively. Collectively, these findings suggested that the research has offered a highly sensitive and selective method for ricin detection, which was not only easy to operate but also provided efficient results. The scheme showed great potential for the verification of chemical weapons and the destruction of toxic chemicals, therefore representing a significant advancement in the field of biomolecular detection and analysis. Full article

Can we think of the legendary Wandering Jew as a monster? The figure does not easily fit the common definition of a monster and yet, the Wandering Jew is extraordinary. In the medieval and early modern sources of the legend, the Wandering Jew, who once sinned against Christ and is therefore doomed to be an immortal eyewitness to the Passion, serves as a model for the faithful. In his 1796 gothic novel, The Monk, Matthew Lewis creates a new strand of the Wandering Jew tradition, a gothic Wandering Jew, a being transformed from wonder to horror through association with centuries of antisemitic accusations against Jews as agents of conspiracy, ritual murder, nefarious magic, and disease. This essay argues that a variation on the representation of the gothic Wandering Jew, which began with Coleridge’s Rime of the Ancient Mariner, further adapts the legend to make the Wanderer not a sign of redemption, but the monstrous cause of catastrophe not only for himself, but for those he encounters. This article, the first scholarly examination of John Blackburn’s 1972 Wandering Jew novel, Devil Daddy, situates it within the strand of the legend that represents the Wandering Jew as a monstrous source of destruction. Blackburn’s novel, written during a time of global concern over the development of biological weapons of mass destruction, portrays the Wandering Jew’s curse as a source of manmade global environmental catastrophe. In this way, the sin of the monstrous Wandering Jew becomes one not against Christ, but against humankind. Even as Devil Daddy explicitly references the horrors of the Holocaust, this representation of a monstrous Wandering Jew haunts the text, undermining its sympathetic representation of Jewish suffering. Full article

Performing research data governance is critical for preventing the transfer of technologies related to weapons of mass destruction (WMD). While research data governance is common in developed countries, it is still often considered less necessary by research organizations in developing countries such as Indonesia. An investigation of research data governance behavior for Indonesian scientists was conducted in this study. The theories of planned behavior (TPB) and protection motivation (PMT) were used to explain the relationships between different factors influencing scientists’ behavior. The theories have been widely used in the information security domain, and the approach was adopted to build the research model of this study. The obtained data were analyzed using partial least-squares structural equation modeling (PLS-SEM) to answer the main research question: “what factors determine the likelihood of practicing research data governance by Indonesian scientists to prevent WMD-applicable technology transfer?” By learning what motivates scientists to adopt research data governance practices, organizations can design relevant strategies that are directed explicitly at stimulating positive responses. The results of this study can also be applied in other developing countries that have similar situations, such as Indonesia. Full article

The pulsed high power microwave (HPM) technology has been developed worldwide for over 20 years. The sources of HPM pulses are a weapon of mass destruction. They pose danger especially to computer and telecommunications equipment and systems, both the military and civilian ones. This paper presents a survey of literature on electromagnetic wave radiation absorbing and shielding materials to be used in construction. Relevant protective measures should include the shielding of buildings or their parts and the absorption of radiation by building envelopes and their elements. The main focus is on the possibilities of improving the shielding and absorptive properties of common construction materials, such as concrete, mortars and synthetic resins. The survey covers the following groups of materials: carbon-based admixtures, nickel powder, iron powders, ferrites, magnetite and polymers. The final part of the survey is devoted to hybrid foam microwave absorbers in which the shape of the material’s inner structure and that of its surface play a special role. Full article

Kazakhstan and the United States have partnered since 2003 to counter the proliferation of weapons of mass destruction. The US Department of Defense (US DoD) has funded threat reduction programs to eliminate biological weapons, secure material in repositories that could be targeted for theft, and enhance surveillance systems to monitor infectious disease outbreaks that would affect national security. The cooperative biological research (CBR) program of the US DoD’s Biological Threat Reduction Program has provided financing, mentorship, infrastructure, and biologic research support to Kazakhstani scientists and research institutes since 2005. The objective of this paper is to provide a historical perspective for the CBR involvement in Kazakhstan, including project chronology, successes and challenges to allow lessons learned to be applied to future CBR endeavors. A project compendium from open source data and interviews with partner country Kazakhstani participants, project collaborators, and stakeholders was developed utilizing studies from 2004 to the present. An earlier project map was used as a basis to determine project linkages and continuations during the evolution of the CBR program. It was determined that consistent and effective networking increases the chances to collaborate especially for competitive funding opportunities. Overall, the CBR program has increased scientific capabilities in Kazakhstan while reducing their risk of biological threats. However, there is still need for increased scientific transparency and an overall strategy to develop a capability-based model to better enhance and sustain future research. Finally, we offer a living perspective that can be applied to further link related studies especially those related to One Health and zoonoses and the assessment of similar capability-building programs. Full article

In this paper, an attempt is made to analyze the potential threats and consequences of cyber conflicts and, in particular, the risks of a global cyber conflict. The material is based on a comprehensive analysis of the nature of cyber conflict and its elements from both technical and societal points of view. The approach used in the paper considers the societal component as an essential part of cyber conflicts, allowing basics of cyber conflicts often disregarded by researchers and the public to be highlighted. Finally, the conclusion offers an opportunity to consider cyber conflict as the most advanced form of modern warfare, which imposes the most serious threat and whose effect could be comparable to weapons of mass destruction. Full article

This paper aims at explaining the lessons learned from the chemical attacks that took place in 2013 in the Syrian military conflict, especially the sarin attacks on the Ghouta area of Damascus on August 21. Despite the limitations the UN Mission found while investigating the use of chemical weapons (CW) in Syria, some interesting conclusions for the scientific and medical community can be obtained from its reports. These include the advantages of the Chemical Weapons Convention procedure for the investigation of alleged CW use, when compared with the United Nations mechanism for similar investigations, the difficulties of differential diagnosis based only on clinical signs and symptoms and the impact of secondary contamination when responding to a CW attack. Full article

The possibility of a terrorist attack employing the use of chemical or biological weapons of mass destruction (WMD) on American soil is no longer an empty threat, it has become a reality. A WMD is defined as any weapon with the capacity to inflict death and destruction on such a massive scale that its very presence in the hands of hostile forces is a grievous threat. Events of the past few years including the bombing of the World Trade Center in 1993, the Murrah Federal Building in Oklahoma City in 1995 and the use of planes as guided missiles directed into the Pentagon and New York’s Twin Towers in 2001 (9/11) and the tragic incidents involving twentythree people who were infected and five who died as a result of contact with anthrax-laced mail in the Fall of 2001, have well established that the United States can be attacked by both domestic and international terrorists without warning or provocation. In light of these actions, hospitals have been working vigorously to ensure that they would be “ready” in the event of another terrorist attack to provide appropriate medical care to victims. However, according to a recent United States General Accounting Office (GAO) nationwide survey, our nation’s hospitals still are not prepared to manage mass causalities resulting from chemical or biological WMD. Therefore, there is a clear need for information about current hospital preparedness in order to provide a foundation for systematic planning and broader discussions about relative cost, probable effectiveness, environmental impact and overall societal priorities. Hence, the aim of this research was to examine the current preparedness of hospitals in the State of Mississippi to manage victims of terrorist attacks involving chemical or biological WMD. All acute care hospitals in the State were selected for inclusion in this study. Both quantitative and qualitative methods were utilized for data collection and analysis. Six hypotheses were tested. Using a questionnaire survey, the availability of functional preparedness plans, specific preparedness education/training, decontamination facilities, surge capacity, pharmaceutical supplies, and laboratory diagnostic capabilities of hospitals were examined. The findings revealed that a majority (89.2%) of hospitals in the State of Mississippi have documented preparedness plans, provided specific preparedness education/training (89.2%), have dedicated facilities for decontamination (75.7%), and pharmaceutical plans and supplies (56.8%) for the treatment of victims in the event of a disaster involving chemical or biological WMD. However, over half (59.5%) of the hospitals could not increase surge capacity (supplies, equipment, staff, patient beds, etc.) and lack appropriate laboratory diagnostic services (91.9%) capable of analyzing and identifying WMD. In general, hospitals in the State of Mississippi, like a number of hospitals throughout the United States, are still not adequately prepared to manage victims of terrorist attacks involving chemical or biological WMD which consequently may result in the loss of hundreds or even thousands of lives. Therefore, hospitals continue to require substantial resources at the local, State, and national levels in order to be “truly” prepared. Full article

Ion mobility spectrometry (IMS) is recognized as one of the most sensitive and robust techniques for the detection of narcotics, explosives and chemical warfare agents. IMS is widely used in forensic, military and security applications. Increasing threat of terrorist attacks, the proliferation of narcotics, Chemical Weapons Convention (CWC) treaty verification as well as humanitarian de-mining efforts have mandated that equal importance be placed on the time required to obtain results as well as the quality of the analytical data. [1] In this regard IMS is virtually unrivaled when both speed of response and sensitivity have to be considered. [2] The problem with conventional (signal averaging) IMS systems is the fixed duty cycle of the entrance gate that restricts to less than 1%, the number of available ions contributing to the measured signal. Furthermore, the signal averaging process incorporates scan-to-scan variations that degrade the spectral resolution contributing to misidentifications and false positives. With external second gate, Fourier Transform ion mobility spectrometry (FT-IMS) the entrance gate frequency is variable and can be altered in conjunction with other data acquisition parameters (scan time and sampling rate) to increase the spectral resolution to reduce false alarms and improve the sensitivity for early warning and contamination avoidance. In addition, with FT-IMS the entrance gate operates with a 50% duty cycle and so affords a seven-fold increase in sensitivity. Recent data on high explosives are presented to demonstrate the parametric optimization in sensitivity and resolution of our system. Full article