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Keywords = uterosomes

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30 pages, 2238 KB  
Review
Tetraspanins, More than Markers of Extracellular Vesicles in Reproduction
by Jana Jankovičová, Petra Sečová, Katarína Michalková and Jana Antalíková
Int. J. Mol. Sci. 2020, 21(20), 7568; https://doi.org/10.3390/ijms21207568 - 14 Oct 2020
Cited by 239 | Viewed by 12014
Abstract
The participation of extracellular vesicles in many cellular processes, including reproduction, is unquestionable. Although currently, the tetraspanin proteins found in extracellular vesicles are mostly applied as markers, increasing evidence points to their role in extracellular vesicle biogenesis, cargo selection, cell targeting, and cell [...] Read more.
The participation of extracellular vesicles in many cellular processes, including reproduction, is unquestionable. Although currently, the tetraspanin proteins found in extracellular vesicles are mostly applied as markers, increasing evidence points to their role in extracellular vesicle biogenesis, cargo selection, cell targeting, and cell uptake under both physiological and pathological conditions. In this review, we bring other insight into the involvement of tetraspanin proteins in extracellular vesicle physiology in mammalian reproduction. We provide knowledge regarding the involvement of extracellular vesicle tetraspanins in these processes in somatic cells. Furthermore, we discuss the future direction towards an understanding of their functions in the tissues and fluids of the mammalian reproductive system in gamete maturation, fertilization, and embryo development; their involvement in mutual cell contact and communication in their complexity. Full article
(This article belongs to the Special Issue Extracellular Vesicles in Reproduction)
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