Search Results (5,458)

Long-fiber thermoplastic (LFT) materials are a versatile category of composite materials that can be directly compounded (LFT-D) in twin screw extruders and compression molded. Originating in the automotive sector, the LFT-D process is becoming increasingly attractive for other industries where low cycle times, lightweight performance and recyclability are required. The purpose of this work is to summarize mechanical properties and findings from the investigations into LFT-D process–microstructure–property relationships and present a design of experiments (DoE) study based on the current state of the art. Primary parameters from LFT-D compounding, screw speed, fiber roving amount and polymer throughput m_p are chosen as DoE factors. Polyamide 6 (PA6) is reinforced with a glass fiber (GF) mass fraction w_f between w_f = 20% and w_f = 60%. Tensile, flexural and impact properties are chosen as DoE output parameters, characterized and discussed in relation to the state of the art. The unique microstructure of LFT-D materials, especially the existence of a charge and flow area as well as the fiber migration, is considered in the discussion. All mechanical properties characterized have a linear relation to w_f. This study demonstrates the interactive relationship between the main factors and w_f, which significantly influences the mechanical properties. This dependence of w_f on the DoE factors is accounted for in advanced response contour plots proposed in this work. Parameter recommendations for the screw speed are reported by ranges of w_f and polymer throughput for the goal of maximum mechanical properties or low coefficient of variations. At w_f < 30% a low screw speed is recommended to improve most mechanical properties as well as the coefficient of variation. Full article

Background: Artificial intelligence (AI) is poised to fundamentally reshape healthcare delivery, offering unprecedented advancements in diagnostics, treatment personalization, and operational efficiency. However, a growing body of international research reveals a critical “optimism–knowledge gap”: healthcare professionals are enthusiastic about AI’s potential but possess limited technical knowledge and practical experience. This gap compromises the safe and effective implementation of AI tools. The Italian healthcare context presents a unique and amplifying challenge, as it is defined by the stringent “human-in-the-loop” oversight mandated by the Garante per la protezione dei dati personali (Italy’s Data Protection Authority). This legal framework makes clinician competence not just a goal, but a prerequisite for regulatory compliance. Objective: This study aimed to provide an exploratory quantitative assessment of AI awareness, practical application, and understanding of its limitations among a sample of clinicians in Italy. It specifically sought to compare the preparedness of hospital-based clinicians and general practitioners (GPs) and to identify the workforce’s perceived educational needs within this unique legal environment. Methods: A descriptive, cross-sectional survey was conducted from February to August 2025. Using a non-probability convenience sampling method via professional networks, the survey yielded 362 total responses. Data were analyzed descriptively and inferentially using Chi-square (${\chi }^2$) tests to compare cohort responses on familiarity, practical exposure, knowledge of limitations, and interest in further training. Results: A universal and high demand for education was found, with 89.9% of all respondents being “Moderately” or “Very” interested in learning more about AI. This optimism coexists with dangerously low practical exposure. The gap was most profound among GPs, 44.1% of whom have “Never” used an AI tool—a rate significantly higher than hospital clinicians (34.9%; ${\chi }^2=3.14$, p = 0.045). Furthermore, 32.6% of GPs admitted that they “understand some benefits but not the limitations.” Conclusions: Italian clinicians mirror the global optimism–knowledge gap. These findings underscore the urgent need for structured, continuous education in AI literacy to address ethical and regulatory imperatives within the Italian healthcare system. Full article

Background and Clinical Significance: Mycobacterial infections of the central nervous system (CNS) are a serious condition that demands a rapid interdisciplinary approach according to the most recent protocols. Some cases, however, are unique and not yet reported in the literature. Case Presentation: We report such a case, a 42-year-old Greek male patient with a Mycobacterium xenopi infection of the cerebrodura near the cavernous sinus, an infection not yet reported in the literature and a real challenge for the treating doctors due to the location of the infection and the complication-rich course. Conclusions: This is the first reported intracerebral infection with Mycobacterium xenopi. We share our experience to assist clinicians with similar cases. Full article

Background: Emotion regulation and attachment styles are interrelated and are critical factors in psychopathology and treatment outcomes, particularly in youths with suicidal behavior receiving psychiatric inpatient care. This study examined the influence of emotion regulation and attachment style on psychiatric hospitalization duration among adolescents admitted due to suicidal ideation or behavior. Methods: Participants included 79 Israeli adolescents (mean age 15.35 years, 87.3% female) admitted to a tertiary psychiatric inpatient unit following a suicidal crisis. Data was collected using the Difficulties in Emotion Regulation Scale (DERS), the Experience in Close Relationships Scale (ECR), the Screen for Child Anxiety-Related Emotional Disorders (SCARED), the Patient Health Questionnaire (PHQ-9), and the Columbia-Suicide Severity Rating Scale (C-SSRS). Data were analyzed using correlation and multiple regression analyses. Results: Analysis revealed that greater emotion regulation difficulties predicted longer hospitalization duration (β = 0.41, p < 0.001), while avoidant attachment style was associated with shorter hospitalization duration (β = −0.35, p < 0.001). Notably, the level of suicidality as well as psychopathology symptoms (depression and anxiety) did not predict hospitalization duration. Conclusions: These findings underscore the important role of emotion regulation and attachment style in determining treatment duration in suicidal adolescents, beyond the severity of psychopathology and suicidality, suggesting their unique contribution to treatment planning. Clinical interventions targeting emotion regulation and attachment styles could enhance inpatient care effectiveness, offer a more personalized treatment approach and potentially reducing hospitalization duration. Full article

Complex I (NADH:quinone oxidoreductase, CI) is central to cellular aerobic energy metabolism. The L-shaped structure of CI is unique, where the hydrophilic arm is responsible for the electron transfer function and the membrane arm operates proton pumping. These two functional sites are spatially far apart yet functionally connected. This basic core subunit architecture is highly conserved from bacterial to mammalian CI. Here, to gain detailed mechanistic insight into the role of the membrane subunit ND2 in the coupling mechanism, we mutated several highly conserved residues in the middle of the membrane axis of NuoN, the E. coli CI homolog of ND2. To more precisely investigate the consequences of mutational effects on highly conserved residues, we purified each mutant CI and compared the mutational effects on electron transfer and proton pumping activity using our instant membrane reconstitution method with E. coli double knockout (DKO) membrane vesicles lacking both CI and alternative NADH dehydrogenase (NDH-2). Thre results were corroborated by conventional proteoliposome reconstitution experiments. We found that Lys247 and Lys395 are absolutely essential for both electron transfer and proton pumping activities, while about 50% reduction of NADH oxidase activity but no reduction in proton pumping activity was observed in Lys217, and no significant decrease was detected in Glu133. Furthermore, unexpectedly, we were able to purify an NuoN knockout (ΔNuoN) mutant, which contained stoichiometric peripheral subunits NuoB, NuoCD, NuoE, NuoF, NuoG, and NuoI; and a substoichiometric amount of NuoH and a reduced amount of quinone. However, surprisingly, this isolated ΔNuoN CI showed CI activities (~30% of the WT) after being reconstituted into DKO membranes but not into proteoliposomes. Later, we confirmed by blue native PAGE that the wild-type CI was partially formed from ΔNuoN CI by recruiting its missing membrane subunits that existed in DKO membranes. Our data strongly suggest that ND2/NuoN plays an essential role in the coupling mechanism in CI. CI is the entry respiratory chain enzyme and is central to cellular energy metabolism. Two highly conserved lysine residues in the center of the antiporter-like membrane subunit ND2 are essential for the coupling mechanism between electron transfer and proton translocation. Full article

Workplace harassment of transgender employees remains pervasive and understudied. In this narrative review of 63 studies over the past 25 years, we summarize the literature on transgender workplace harassment. We focus on its prevalence and forms. Individual, organizational and cultural factors contribute to its occurrence; psychological and occupational outcomes; and strategies to reduce or prevent harassment. We find that harassment often extends beyond traditional definitions; includes misgendering, deadnaming, and the questioning or outright denial of one’s gender identity; and is particularly pervasive in masculinity contest cultures. These experiences are associated with both negative well-being of transgender employees and less effectiveness of the organizations that employ them, though more causal evidence is needed. We also highlight critical conceptual and methodological gaps to guide future research. Much of the existing research on LGBTQ+ employees in the workplace has focused primarily on sexual minorities, leaving the unique experiences of gender minorities invisible. Further, an intersectional lens is needed, as harassment experiences of trans women, trans men, and nonbinary people may differ in significant ways. Finally, we identify strategies to improve workplace climate including both top-down formal policy and bottom-up interpersonal behaviors. Full article

Saudade is a cultural concept expressing a profound sense of longing, nostalgia, or melancholy associated with absence, loss, or unattainable experiences. Emerging in medieval Portugal and shaped by historical, social, and literary developments, it has evolved from an individual emotion into a collective cultural construct reflecting the identity, history, and aesthetic sensibilities of Lusophone communities. Drawing on peer-reviewed scholarship and interdisciplinary research in cultural studies, this entry examines how saudade is expressed in the literature, music, and philosophical discourse, and its role in national memory, emigration, and cultural imagination. While sometimes described as untranslatable, its uniqueness reflects deep historical and cultural embedding rather than a linguistic limitation. Saudade, therefore, functions as a multilayered symbolic category, revealing the interplay between emotion, language, and cultural identity in Lusophone contexts. Full article

Research on financial risk tolerance and risk-taking increasingly incorporates personality traits into predictive and descriptive models of risk-taking behavior; however, intercorrelations among traits can obscure the unique contributions of individual traits. This is known as the suppressor effect. This study employed a two-stage analytic framework to test and adjust for suppressor effects across the Big Five personality dimensions in describing financial risk tolerance. In Stage 1, correlation and OLS regression analyses identified suppression patterns, revealing that the explanatory validity of some factors was distorted by shared variance. In Stage 2, suppression-adjusted trait estimates were used to reassess their unique association with financial risk-taking mediated through financial risk tolerance. Results indicate that Openness to Experience and Extraversion are the strongest descriptors of financial risk-taking once suppressor effects are controlled. At the same time, Agreeableness and Conscientiousness contribute modestly and context-dependently to descriptions of financial risk-taking. These findings demonstrate that ignoring suppression effects can lead to mischaracterizing the role of personality in financial decision-making. This study shows that more precise estimates of trait influences can improve theoretical models of investor behavior and enhance the delivery of financial advice and education. Full article

The Xingqi (行气, breath circulation) pattern bronze mirrors of the Song Dynasty (960–1279 CE) represent a distinctive category of Daoist material culture in southern China. Despite their unique iconography, systematic research on their functions and religious significance has been lacking. This study examines sixteen Xingqi pattern bronze mirrors through iconographic analysis and textual research, integrating evidence from surviving Daoist scriptures and ritual manuals. Two primary types are identified: the “Tortoise-Swallowing and Crane-Breathing Style” and the “Sun and Moon Observing Style”. The former depicts practitioners imitating the breathing techniques of tortoises and cranes, while the latter shows figures gazing upward to ingest the essences of the sun and moon. Both motifs continue earlier health preservation traditions from the Pre-Qin (221–207 BCE) through Han dynasties, adapted within the Northern and Southern Song context. These mirrors were specifically used by Daoists along the middle Yangtze River for inner alchemy cultivation, particularly in visualized Cunsi (存思, contemplation practices). They were predominantly passed down through generations rather than buried, explaining their scarcity in archaeological contexts. These artifacts illuminate how Song Daoism translated abstract philosophical concepts into tangible, operable practices through material imagery. They provide new physical evidence for understanding historical Daoist cultivation methods and the materialization of religious experience. Full article

Objectives: Survivors of mild-grade aneurysmal subarachnoid hemorrhage (aSAH) often achieve favorable neurological recovery, yet many continue to experience cognitive difficulties and reduced health-related quality of life (HRQoL). The relative contribution of objectively measured cognition and subjective cognitive complaints to long-term HRQoL in this population remains insufficiently clarified. Methods: This prospective cohort study assessed objective and subjective cognitive functioning one year after mild-grade aSAH (Hunt & Hess I–II) and examined their unique contributions to HRQoL. Forty endovascularly treated aSAH survivors and 80 neurologically healthy controls, matched for sex, age, and educational level, were assessed 12–14 months post-ictus using the Montreal Cognitive Assessment (MoCA), Cognitive Failures Questionnaire (CFQ), and SF-36. Results: Compared with controls, patients demonstrated significantly lower MoCA scores, with cognitive impairment present in 42.5% of cases, as well as reduced HRQoL. In multivariate regression analyses adjusted for demographic, clinical, and affective covariates, subjective cognitive complaints (CFQ) remained independently associated with the mental component summary score of the SF-36 (β = −0.47, p = 0.002). Objective cognitive performance (MoCA) was not associated with the SF-36 component summary scores but showed weaker, domain-specific associations in exploratory analyses. The correlation between MoCA and CFQ was weak (ρ = −0.33), indicating a dissociation between these two measures. Conclusions: One year after mild-grade aSAH, subjective cognitive complaints contribute to mental HRQoL above and beyond the influence of affective symptoms. These findings highlight a clinically relevant dissociation between perceived and objectively measured cognition and support the importance of incorporating patient-reported cognitive difficulties into long-term outcome assessment and rehabilitation planning. Full article

Anishnawbe Health Toronto (AHT) is Canada’s largest multidisciplinary Indigenous health centre. In 2023, the Executive Director of AHT spearheaded a community-centered research study looking at mental and spiritual health for its community of service users. This project sought to support cultural resurgence efforts in AHT health programming through the synthesis of Indigenous-informed models and understandings of mental health, rooted in the knowledge and experience of care providers at AHT. This project also sought to enhance Indigenous community research capacity by involving Indigenous community stakeholders in each stage of the qualitative research process. This paper details these methods, which follow Indigenous community ethics in research, and include both Indigenous approaches to research as well as qualitative methods. This paper then presents a summary of the study’s findings, describing the interdisciplinary mental health services of a team of Indigenous and non-Indigenous practitioners at AHT. Three major themes describe the unique features of these services: The Healing Relationship, Indigenous Spaces and Identities as a “Sacred Home”, and Healing Through Spirit. The connection between spirituality and Indigenous wellness is discussed by centering Indigenous values and ways of knowing as central to Indigenous healing, survivance, and cultural resurgence. Full article

Multilingual research offers a unique window into the diverse developmental trajectories of language and cognition; yet this research has largely been built on a monolingual framework. Here, we first describe how a monolingual bias has limited theory construction and research on the multilingual experience. We then apply a developmental systems framework to understand the multilingual experience, shifting the field away from a monolingual bias toward centering the lived language experiences of multilingual children. At the center of our framework are the moment-to-moment, multimodal, and dynamic interactions between children, their social partners, and environment. Contributing to interaction dynamics are child and social partner characteristics (cognition, motivation, and experiences), as well as contextual factors (activities, places, and policies) that can shape multilingual exposure. Cultural practices, values, and beliefs, as well as developmental time at the micro level (seconds, hours, days) and the macro level (weeks, months, and years), permeate all levels of the framework. Our proposal reveals important avenues of future research, including (1) understanding the dynamic coordination of multimodal behaviors and languages within interactions, (2) how experiences specific to minoritized communities (e.g., language discrimination) shape interaction dynamics, (3) how the temporal patterns of language experience at the micro level contribute to long-term multilingual exposure, and (4) understanding experiences of different multilingual communities within and across communities. Use of this framework can advance knowledge of the contexts enriching multilingual experiences and reconstruct multilingual development research for the benefit of multilingual learners. Full article

With the expansion of global oil and gas resource exploration and development into deep and ultra deep layers, the efficient development of deep carbonate rock fracture cave reservoirs has become the key to ensuring energy security. However, this type of reservoir commonly faces high temperatures, high salinity, and extremely strong heterogeneity, leading to increasingly severe water content spikes caused by dominant water flow channels. Although the existing traditional inorganic plugging agent has good temperature resistance, it has the defects of great brittleness and easy cracking, while the organic polymer gel is prone to degradation failure under high temperature and high salt environments. In order to solve the above problems, a new biochar-enhanced inorganic composite gel system was constructed by using biochar prepared from agricultural and forestry waste pyrolysis as a functional enhancement component. Through rheological testing, high-temperature and high-pressure mechanical experiments, long-term thermal stability evaluation, and dynamic sealing experiments of fractured rock cores, the reinforcement and toughening laws and rheological control mechanisms of biochar on inorganic matrices were systematically studied. Research has found that a biochar content of 0.5 wt% can significantly improve the micro pore structure of the matrix. By utilizing its micro aggregate filling effect and interfacial chemical bonding, the compressive strength of the solidified body can be increased to over 2 MPa, and there is no significant decline in strength after aging at 130 °C for 30 days. More importantly, the unique “adsorption slow-release” mechanism of biochar effectively stabilizes the hydration reaction kinetics at high temperatures, extending the solidification time of the system to 15 h and solving the problem of flash condensation in deep well pumping. This system exhibits excellent shear thinning characteristics and crack sealing ability, and presents a unique “yield reconstruction” toughness sealing feature. This study elucidates the multidimensional strengthening mechanism of biochar in inorganic cementitious materials, providing technical reference for stable oil and water control in deep fractured reservoirs. Full article

Digital platforms became central to institutional participation during the COVID-19 pandemic, yet little is known about how participants experience digitally mediated decision-making processes and which conditions foster high-quality deliberation. Guided by an ecological perspective from community psychology, this study examined university staff’s experiences with platform-based participation, focusing on the relationship between online participation practices, digital empowerment, and perceived deliberative quality. In November 2021, faculty and technical/administrative staff at an Italian university (N = 673) completed an online questionnaire assessing platform use (Microsoft Teams), participation practices, perceived benefits and limitations of digital platforms, digital empowerment, and deliberative quality (critical awareness and engagement). Exploratory factor analyses supported multidimensional measures of platform perceptions and deliberative quality. Hierarchical regression analyses showed that interaction rules and perceived improvements in participation processes were the strongest predictors of deliberative quality. Platform benefits related to participatory quality were positively associated with both outcomes, while efficiency-related benefits showed a small negative association with critical awareness. Digital empowerment uniquely predicted deliberative engagement above and beyond participation practices. Overall, results suggest that deliberative quality in digital institutional settings depends more on structured interaction and empowerment-supportive conditions than on platform use frequency, with implications for designing sustainable online and hybrid participatory processes. Full article

Medieval literature often seems to be a remote, irrelevant, incomprehensible world of narrative texts lost in heroic, religious, or courtly themes, limited to stories about King Arthur, courtly lovers, military heroes, and religious martyrs, saints, and prophets. In reality, as any expert can easily confirm, when we turn our full attention to pre-modern literature from across Europe (and also other parts of the world), we can often recognize the true extent to which poets utilized their narratives for spiritual, philosophical, religious, scientific, and medical explorations that have much to tell us today and prove to be deeply meaningful in a timeless manner. One key aspect, which was shared among virtually all medieval artists, poets, and theologians, consisted of the unique experience by an individual who is entitled through a physical opening to see into the depth or the height of all existence and can thus discover a wholly different world. Through this motif of the gaze, an entire epiphanic realization can set in, which thus quickly transforms the purely entertaining narrative medium into a narrative catalyst of profound spiritual experiences, helping the individual to gain inspiration from the Godhead (e.g., mysticism). Indeed, numerous times, medieval poets employed the motif of the visionary gaze, developed in very concrete terms, to trace and explain the process of perspicuity and accompanying acuity which ultimately leads to new intellectual, emotional, and religious understandings and experiences. While many intellectuals already embraced this notion of a visionary concept of spiritual comprehension, it might come as a surprise that secular and religious poets also operated quite intentionally with the concept of a hole in the wall or some other opening as a springboard for intellectual and spiritual experiences, directly drawing from the concepts of the optical sciences as understood at that time. Oddly but highly significantly, Christian and pagan notions tend to intersect in those narrative moments, particularly in late medieval literature, merging the visionary experience with the monstrous within human society, associating the gaze with the erotic and religious dimension. Full article