Search Results (9,838)

Sepsis is a clinical syndrome characterized by a dysregulated host response to infection, frequently resulting in septic shock and multi-organ failure. Emerging evidence highlights the critical role of neutrophil extracellular traps (NETs) in the pathophysiology of sepsis. NETs are extracellular structures composed of chromatin DNA, histones, and granular proteins released by neutrophils through a specialized form of cell death known as NETosis. While NETs contribute to the containment of pathogens, their excessive or dysregulated production in sepsis is associated with endothelial damage, immunothrombosis, and organ dysfunction. Several NET-associated biomarkers have been identified, including circulating cell-free DNA (cfDNA), histones, MPO-DNA complexes, and neutrophil elastase–DNA complexes, which correlate with the disease severity and prognosis. Therapeutic strategies targeting NETs are currently under investigation. Inhibition of NET formation using PAD4 inhibitors or ROS scavengers has shown protective effects in preclinical models. Conversely, DNase I therapy facilitates the degradation of extracellular DNA, reducing the NET-related cytotoxicity and thrombotic potential. Additionally, heparin and its derivatives have demonstrated the ability to neutralize NET-associated histones and mitigate coagulopathy. Novel approaches include targeting upstream signaling pathways, such as TLR9 and IL-8/CXCR2, offering further therapeutic promise. Full article

Numerical simulations enable us to couple multiphase flow and geochemical processes to evaluate how sequestration impacts brine chemistry and reservoir properties. This study investigates these impacts during CO₂ storage at the San Juan Basin CarbonSAFE (SJB) site. The hydrodynamic model was calibrated through history-matching, utilizing data from saltwater disposal wells to improve predictive accuracy. Core-scale simulations incorporating mineral interactions and equilibrium reactions validated the model against laboratory flow-through experiments. The calibrated geochemical model was subsequently upscaled into a field-scale 3D model of the SJB site to predict how mineral precipitation and dissolution affect reservoir properties. The results indicate that the majority of the injected CO₂ is trapped structurally, followed by residual trapping and dissolution trapping; mineral trapping was found to be negligible in this study. Although quartz and calcite precipitation occurred, the dissolution of feldspars, phyllosilicates, and clay minerals counteracted these effects, resulting in a minimal reduction in porosity—less than 0.1%. The concentration of the various ions in the brine is directly influenced by dissolution/precipitation trends. This study provides valuable insights into CO₂ sequestration’s effects on reservoir fluid dynamics, mineralogy, and rock properties in the San Juan Basin. It highlights the importance of reservoir simulation in assessing long-term CO₂ storage effectiveness, particularly focusing on geochemical interactions. Full article

This study investigates the ionization balance of Sn ions in an electron beam ion trap (EBIT). Highly charged Sn ions are produced via collisions with a quasi-monochromatic electron beam, and the charge state distribution is analyzed using a Wien filter. Significant Sn¹⁵⁺ production occurs at electron energies below the ionization potential of Sn¹⁴⁺ (379 eV). Calculations attribute this to electron-impact ionization from metastable Sn¹⁴⁺ states. Full article

Habitat fragmentation restricts the movement of large mammals across broad landscapes, leading to isolation of individuals or groups, reduced interaction with other species, and limited access to vital resources in surrounding habitats. In this study, we aimed to determine the wildlife ecological corridors for five large mammals (Ursus arctos, Cervus elaphus, Capreolus capreolus, Sus scrofa, and Canis lupus) between Kastamonu Ilgaz Mountain Wildlife Refuge and Gavurdağı Wildlife Refuge. In the field studies, we used the transect, indirect observation, and camera-trap methods to collect presence data. Maximum Entropy (MaxEnt) (v. 3.4.1) software was used to create habitat suitability models of the target species, which are based on the presence-only data approach. The results indicated that AUC values varied between 0.808 and 0.835, with water sources, stand type, and slope contributing most significantly to model performance. In order to determine wildlife ecological corridors, resistance surface maps were created using the species distribution models (SDMs), and bottleneck areas were determined. The Circuit Theory approach was used to model the connections between ecological corridors. As a result of this study, we developed connectivity models for five large mammals based on Circuit Theory, identified priority wildlife ecological corridors, and evaluated critical connection points between two protected areas, Ilgaz Mountain Wildlife Refuge and Gavurdağı Wildlife Refuge. These findings highlight the essential role of ecological corridors in sustaining landscape-level connectivity and supporting the long-term conservation of wide-ranging species. Full article

In order to improve the inversion accuracy of electrical resistivity tomography (ERT) and overcome the limitations of traditional linear methods, this paper proposes an improved shuffled frog leaping algorithm (SFLA). First, an equilibrium grouping strategy is designed to balance the contribution weight of each subgroup to the global optimal solution, suppressing the local optimum traps caused by the dominance of high-quality groups. Second, an adaptive movement operator is constructed to dynamically regulate the step size of the search, enhancing the guiding effect of the optimal solution. In synthetic data tests of three typical electrical models, including a high-resistivity anomaly with 5% random noise, a normal fault, and a reverse fault, the improved algorithm shows an approximately 2.3 times higher accuracy in boundary identification of the anomaly body compared to the least squares (LS) method and standard SFLA. Additionally, the root mean square error is reduced by 57%. In the engineering validation at the Baota Mountain mining area in Jurong, the improved SFLA inversion clearly reveals the undulating bedrock morphology. At a measuring point 55 m along the profile, the bedrock depth is 14.05 m (ZK3 verification value 12.0 m, error 17%), and at 96 m, the depth is 6.9 m (ZK2 verification value 6.7 m, error 3.0%). The characteristic of deeper bedrock to the south and shallower to the north is highly consistent with the terrain and drilling data (RMSE = 1.053). This algorithm provides reliable technical support for precise detection of complex geological structures using ERT. Full article

This study presents a comprehensive analysis of CO₂ trapping mechanisms in subsurface reservoirs by integrating numerical reservoir simulations, geochemical modeling, and machine learning techniques to enhance the design and evaluation of carbon capture and storage (CCS) strategies. A two-dimensional reservoir model was developed to simulate CO₂ injection dynamics under realistic geomechanical and geochemical conditions, incorporating four primary trapping mechanisms: residual, solubility, mineralization, and structural trapping. To improve computational efficiency without compromising accuracy, advanced machine learning models, including random forest, gradient boosting, and decision trees, were deployed as smart proxy models for rapid prediction of trapping behavior across multiple scenarios. Simulation outcomes highlight the critical role of hysteresis, aquifer dynamics, and producer well placement in enhancing CO₂ trapping efficiency and maintaining long-term storage stability. To support the credibility of the model, a qualitative validation framework was implemented by comparing simulation results with benchmarked field studies and peer-reviewed numerical models. These comparisons confirm that the modeled mechanisms and trends align with established CCS behavior in real-world systems. Overall, the study demonstrates the value of combining traditional reservoir engineering with data-driven approaches to optimize CCS performance, offering scalable, reliable, and secure solutions for long-term carbon sequestration. Full article

Drosophila suzukii is an invasive pest of many fruit crops worldwide. Employing the Sterile Insect Technique (SIT) could mitigate D. suzukii population growth and crop damage. This study evaluated the efficacy of SIT on commercial fruit, by (1) validating the quality of irradiated sterile males (male mating competitiveness, courtship, and flight performance) in the laboratory, and (2) assessing population suppression and fruit damage reduction in commercial raspberry fields. Treatment with SIT was compared to the grower’s standard chemical insecticide program throughout the season. The principal metrics of efficacy were trap counts of wild adult female D. suzukii in crops and larvae per fruit during harvesting. These metrics together with monitoring of border areas allowed targeting of high-pressure areas with higher releases of sterile males, to maximise efficacy for a given release number. The sterile male D. suzukii were as competitive as their fertile non-irradiated counterparts in laboratory mating competitiveness and flight performance studies while fertility egg-to-pupae recovery was reduced by 99%. In commercial raspberry crops, season-long releases of sterile males significantly suppressed the wild D. suzukii population, compared to the grower standard control strategy; with up to 89% reduction in wild female D. suzukii and 80% decrease in numbers of larvae per harvested fruit. Additionally, relative fruit waste (i.e., percentage of harvested fruits rejected for sale) at harvest was reduced for early, mid and late harvest crops, by up to 58% compared to the grower standard control. SIT has the potential to provide an effective and sustainable strategy for managing D. suzukii in raspberries, increasing marketable yield by reducing adult populations, fruit damage and waste fruit. SIT could therefore serve as a valuable tool for integrated pest management practices in berry production systems. Full article

In Brazil, Plasmodium infections in non-human primates (NHPs) have been associated with P. simium and P. brasilianum, which are morphologically and genetically similar to the human-infecting species P. vivax and P. malariae, respectively. Surveillance and monitoring of wild NHPs are crucial for understanding the distribution of these parasites and assessing the risk of zoonotic transmission. This study aimed to detect the presence of Plasmodium spp. genetic material in Platyrrhini primates from 47 municipalities in the states of Bahia and Minas Gerais. The animals were captured using Tomahawk-type live traps baited with fruit or immobilized with tranquilizer darts. Free-ranging individuals were chemically restrained via inhalation anesthesia using VetBag^® or intramuscular anesthesia injection. Blood samples were collected from the femoral vein. A total of 298 blood and tissue samples were collected from 10 primate species across five genera: Alouatta caraya (25), Alouatta guariba clamitans (1), Callicebus melanochir (1), Callithrix geoffroyi (28), Callithrix jacchus (4), Callithrix kuhlii (31), Callithrix penicillata (175), Callithrix spp. hybrids (15), Leontopithecus chrysomelas (16), Sapajus robustus (1), and Sapajus xanthosthernos (1). Molecular diagnosis was performed using a nested PCR targeting the 18S small subunit ribosomal RNA (18S SSU rRNA) gene, followed by sequencing. Of the 298 samples analyzed, only one (0.3%) from Bahia tested positive for Plasmodium brasilianum/P. malariae. This represents the first detection of this parasite in a free-living C. geoffroyi in Brazil. These findings highlight the importance of continued surveillance of Plasmodium infections in NHPs to identify regions at risk for zoonotic transmission. Full article

Background/Objective: In patients with acute lymphoblastic leukemia (ALL), it has been demonstrated that the treatment has a negative effect on bone health. The n-3 polyunsaturated fatty acids (LCPUFAs-ω3) may attenuate bone resorption. We evaluated the effects of LCPUFAs-ω3, vitamin D, and calcium supplementation on bone turnover markers and changes in vitamin D concentrations during 6 weeks of supplementation and during 6 weeks of post-intervention follow-up in pediatric patients with ALL. Methods: Thirty-six pediatric patients with ALL were randomly assigned to the ω-3VDCa group (100 mg/kg/d LCPUFAs-ω3 + 4000 IU vitamin D + 1000 mg calcium) or the VDCa group (4000 IU vitamin D + 1000 mg calcium) for 6 weeks. Blood samples were collected to determine 25(OH)D, PTH, ICTP, and TRAP-5b (biomarkers of bone resorption) and osteocalcin (OC, a biomarker of bone production) levels at baseline, 6 weeks, and 12 weeks after supplementation. The 25(OH)D analysis was performed using ultra-high-performance liquid chromatography coupled to a mass spectrometer, and PTH and bone turnover markers were measured by ELISA. Results: The 25(OH)D concentration increased in both groups (ω3VDCa group: 19.4 ng/mL vs. 44.0 ng/mL, p < 0.0001; VDCa group: 15.3 ng/mL vs. 42.8 ng/mL, p = 0.018) and remained significantly higher at 12 weeks. At 12 weeks, ICTP showed lower concentrations in the ω-3VDCa group than in the VDCa group (0.74 ng/mL vs. 1.05 ng/mL, p = 0.024). Conclusions: Combined omega-3 and 4000 IU vitamin D supplementation for 6 weeks had a positive effect on bone health, as indicated by serum ICTP, with no effect on serum 25(OH)D levels over vitamin D supplementation alone. Full article

Traps are central to petroleum exploration, where hydrocarbons accumulate during migration. Reservoirs are likewise an essential petroleum system element and serve as the primary medium for hydrocarbon storage. The buried hill is a geological formation highly favorable for reservoir development. However, the factors influencing hydrocarbon accumulation in buried hill reservoirs are highly diverse, especially in areas with complex, active fault systems. Fault systems play a dual role, both in the formation of reservoirs and in the migration of hydrocarbons. Therefore, understanding the impact of complex fault systems helps enhance the exploration success rate of buried hill traps and guide drilling deployment. In the Beibuwan Basin in the South China Sea, buried hill traps are key targets for deep-buried hydrocarbon exploration in this faulted basin. The low level of exploration and research in buried hills globally limits the understanding of hydrocarbon accumulation conditions, thereby hindering large-scale hydrocarbon exploration. By using drilling data, logging data, and seismic data, stress fields and tectonic faults were restored. There are two types of buried hills developed in the Beibuwan Basin, which were formed during the Late Ordovician-Silurian period and Permian-Triassic period, respectively. The tectonic genesis of the Late Ordovician-Silurian period buried hills belongs to magma diapirism activity, while the tectonic genesis of the Permian-Triassic period buried hills belongs to reverse thrust activity. The fault systems formed by two periods of tectonic activity were respectively altered into basement buried hills and limestone buried hills. The negative structural inversion controls the distribution and interior stratigraphic framework of the deformed Carboniferous strata in the limestone buried hill. The faults and derived fractures of the Late Ordovician-Silurian period and Permian-Triassic period promoted the diagenesis and erosion of these buried hills. The faults formed after the Permian-Triassic period are not conducive to calcite cementation, thus facilitating the preservation of the reservoir space formed earlier. The control of hydrocarbon accumulation by the fault system is reflected in two aspects: on the one hand, the early to mid-Eocene extensional faulting activity directly controlled the depositional process of lacustrine source rocks; on the other hand, the Late Eocene-Oligocene, which is closest to the hydrocarbon expulsion period, is the most effective fault activity period for connecting Eocene source rocks and buried hill reservoirs. This study contributes to understanding of the role of complex fault activity in the formation of buried hill traps within hydrocarbon-bearing basins. Full article

The common bed bug, Cimex lectularius L., is a pervasive pest of humans throughout the world. Insecticide resistance, cryptic habits, and proclivity for harborage on human belongings have contributed to its global status as a difficult pest to control. Leaves from common bean plants, Phaseolus vulgaris L., which include numerous trichomes, have traditionally been used to capture wandering bed bugs in southeastern Europe. However, fresh leaves rapidly desiccate once removed from plants, losing their trapping ability. A leaf-derived trapping material was developed that does not desiccate as rapidly as fresh leaves and retains the potential to trap bed bugs. In this study, we tested the efficacy of the leaf-derived material in capturing bed bugs. We tested the leaf-derived material in both horizontal and vertical orientations, using fresh bean leaves as positive controls. When deployed horizontally, the leaf-derived material captured bed bugs of all life stages and both sexes (adults). Leaf-derived material was also found to capture bed bugs in a vertical orientation (only evaluated for adult male bed bugs). Because this experimental leaf-derived material was effective in both horizontal and vertical orientations and against all life stages, it may have great potential for development into bed bug monitoring or exclusion devices. Full article

Grain boundaries are among the most influential structural features that control the charge transport in polycrystalline organic semiconductors. Acting as both charge trapping sites and electrostatic barriers, they disrupt molecular packing and introduce energetic disorder, thereby limiting carrier mobility, increasing threshold voltage, and degrading the stability of organic thin-film transistors (OTFTs). This review presents a detailed discussion of grain boundary formation, their impact on charge transport, and experimental strategies for engineering their structure and distribution across several high-mobility small-molecule semiconductors, including pentacene, TIPS pentacene, diF-TES-ADT, and rubrene. We explore grain boundary engineering approaches through solvent design, polymer additives, and external alignment methods that modulate crystallization dynamics and domain morphology. Then various case studies are discussed to demonstrate that optimized processing can yield larger, well-aligned grains with reduced boundary effects, leading to great mobility enhancements and improved device stability. By offering insights from structural characterization, device physics, and materials processing, this review outlines key directions for grain boundary control, which is essential for advancing the performance and stability of organic electronic devices. Full article

Anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a heterogeneous group of small-vessel vasculitides, characterized by the presence of antibodies binding to myeloperoxidase (MPO) and proteinase-3 (PR3) found in neutrophil granules. Apart from being the target of ANCA, neutrophils actively contribute to the vicious cycle of inflammation and vascular damage in AAV. On the other hand, platelets have recently been recognized as essential for thrombosis and as inflammatory effectors that collaborate with neutrophils, reinforcing the generation of reactive oxygen species (ROS) and the formation of neutrophil extracellular traps (NETs) in those diseases. Neutrophils exhibit morphological and functional heterogeneity in AAV, reflecting the complexity of their contribution to disease pathogenesis. Since long-term immunosuppression may be related to serious infections and malignancies, there is an urgent need for reliable biomarkers of disease activity to optimize the management of AAV. This review summarizes the current understanding of the role of neutrophils and platelets in the pathogenesis of granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA), focusing on their crosstalk, and highlights the potential for identifying novel biomarkers relevant for predicting the disease course and its relapses. Full article

Spodoptera eridania (Stoll, 1781) (Lepidoptera: Noctuidae) is an important pest with a broad host range and growing relevance due to its high dispersal capacity, recent invasions into Africa and Asia, and documented resistance to biological insecticides. Here, we assessed S. eridania flight phenology and seasonal dynamics in the Florida Panhandle, using pheromone trapping data to evaluate population trends and environmental drivers. Moths were collected year-round, showing consistent patterns across six consecutive years, including two distinct annual flight peaks: an early crop season flight around March, and a more prominent flight peak during September–October. Moth abundance followed a negative quadratic relationship with temperature, with peak activity occurring between 15 °C and 26 °C. No significant relationship was found with precipitation or wind. These results underscore the strong influence of abiotic factors, particularly temperature, on seasonal abundance patterns of this species. Our findings offer key insights by identifying predictable periods of high pest pressure and the environmental conditions that drive population increases. Understanding the flight phenology and behavior of this species provides an ultimate contribution to the development of effective IPM and insect resistance management (IRM) programs, promoting the development of forecasting tools for more effective, timely pest management interventions. Full article

Results are reported for a series of small-scale experiments that examine the dispersion of dense gas released upstream of an isolated building. The experiments replicate the geometry of the Thorney Island Phase II field tests and show good qualitative agreement with the flow regimes observed therein. The experiments were run in a water flume, and the flow is characterized by the Richardson number ($Ri$), where high $Ri$ represent relatively high density releases. For low $Ri$ the dense cloud flows over and around the building and any fluid drawn into the building wake is rapidly flushed. However, for high Ri, the dense cloud collapses, flows around the building, and is drawn into the wake. The dense fluid layer becomes trapped in the wake and is flushed by small parcels of fluid being peeled off the top of the layer and driven up and out of the wake. Results are presented for the concentration field along the center plane (parallel to the flow) of the building wake and time series of concentration just above the floor and downstream of the building. The time series for low-$Ri$ and high-$Ri$ flows are starkly different, with differences explained in terms of the observed flow regimes. Full article