Search Results (66)

The extension of high-speed rail (HSR) lines around the world is increasing. The largest network today is in China, followed by Spain, Japan, France, and Italy; currently, new lines are being built in Morocco and Saudi Arabia. The goal of the new lines built is to drastically reduce the time distances between the extreme railway terminals by intervening on the two main components of time: space and speed. The two components have been investigated in various fields of engineering for design conditions (ex ante/a priori). In the literature, there is no analysis of what happened in the realization of the projects (ex post/retrospective). The research problem that arises is to analyze the high-speed lines built in order to verify, given a pair of extreme terminals, how much the length is reduced by passing from a conventional line to a high-speed line, and to verify how this length is getting closer and closer to the distance as the crow flies. The reduction of spatial distance produces direct connections between two territories, making the railway system (HSR) more competitive compared to other transport alternatives (e.g., air travel). To address the problem posed, information and data are collected on European HSR lines, which constitute a sufficiently homogeneous set in terms of railway and structural standards. The planimetric characteristics of specially built lines such as HSR are examined. A test method is proposed, consisting of a model that is useful to compare the length along the HSR line, with direct lengths, and existing conventional lines. The results obtained from the elaborations offer a first answer to the problem posed, demonstrating that in the HSR lines realized the spatial distances approach the distance as the crow flies between the cities located at the extremes, and are always shorter than the lengths of conventional lines. The final indications that can be drawn concern the possibility of using the results obtained as a reference for decision-makers and planners involved in the transport planning process at national and international level. Future research directions should study the values of the indicators in other large HSR networks, such as those built in Asia, and more generally study all the elements of the lines specially built to allow better sustainable planning, reducing the negative elements found and increasing the positive ones. Full article

This article explores the Confucian Classics as foundational texts of rhetorical theory and literary practice (wen ben yu jing 文本于經) in East Asia, arguing that their scriptural authority derives not only from their moral or philosophical content but also from their exemplary literary form. It addresses a scholarly gap concerning the rhetorical dimensions of these texts, especially as interpreted by premodern intellectuals across China, Korea, and Japan. Drawing on case studies of six influential scholars—Liu Xie and Han Yu from Liang and Tang China, Jeong Dojeon and Seong Hyeon from Joseon Korea, and Fujiwara Seika and Ogyū Sorai from Edō Japan—this study examines how each conceptualized and applied rhetorical principles rooted in the Confucian canon. Methodologically, it combines historical, philological, and comparative analysis of primary sources to trace both shared ideals and divergent approaches in their engagement with the Classics. Findings reveal that while these thinkers uniformly upheld the sacred literary status of the Confucian texts, they varied in rhetorical application, corpus selection, and the social and ethical aims of writing. This study concludes that these transnational rhetorical practices constitute a distinct intellectual trend within the Sinographic Cosmopolis, challenging disciplinary boundaries and reaffirming the central role of literary form in the articulation and transmission of Confucian thought. Full article

Background/Objectives: Improving one’s diet for the purpose of promoting health is constrained by people’s ingrained eating habits, as the eating patterns that align with their established habits do not necessarily correspond to a healthy way of eating. In addressing the issue of improving diet while taking both health and habits into consideration, this paper focuses on three concepts of complementarity related to food combinations and presents an approach using Japanese data. Methods: This paper first organizes three concepts of complementarity related to food combinations. The three concepts of complementarity are formulated based on (i) nutrients, (ii) habits, and (iii) recipes. The definitions of measurement scales corresponding to these concepts are also discussed. Results: Using data from a specific region in Japan, we analyzed three types of complementarities related to food combinations across different gender and age groups. This approach enabled us to visualize the potential for dietary improvements and identify effective strategies tailored to each group. For instance, among females aged 50 and above in this region, it was found that recipes incorporating combinations such as (α) milk and pasta, (β) salmon and pasta, (γ) horse mackerel or sardines with carrots, and (δ) onions with taro can efficiently support dietary improvement for this demographic, building upon their established dietary habits. The differences in recommended recipes for each group are due to variations in nutrients that tend to be insufficient and differences in established eating habits. Conclusions: A combination of foods with high (i) complementarity of nutrients constitutes a healthy diet, whereas a combination of foods with low (ii) complementarity in habits reflects dietary behaviors that are not sufficiently practiced within the relevant sub-population at present. Meanwhile, combinations of foods with high (iii) complementarity in recipes can serve as tools to bridge the gap between healthy eating patterns and established dietary habits. Full article

As global warming worsens, there is a growing need to reduce emissions of methane, a greenhouse gas. In agriculture, a water management method called alternate wetting and drying (AWD) has proven effective in mitigating methane emissions from paddy fields. It is, therefore, advisable to disseminate it efficiently. This study was conducted in Shiga Prefecture, Japan, to determine what influences AWD adoption behavior and examine the effectiveness of human networks in promoting AWD. Spatial statistical methods, including Moran’s I and Global G* and the spatial probit model, were employed for the purpose. The analysis results indicate that the behavior of surrounding farmers, which constitutes a spatial factor, influences that of the individual farmers. Moreover, farmers who acquire and use data, those with large-scale production, and those who mainly sell paddy rice tend to implement AWD, whereas corporate-managed farms do not. Therefore, to more efficiently improve the AWD implementation rate in Shiga Prefecture, this study makes several recommendations. Farmers’ active information sharing and technology exchange should be leveraged to strengthen networks and promote best practices for AWD dissemination. Advancing agricultural digitalization and data utilization is crucial, particularly by reducing digital equipment costs and securing technical personnel through public investment. Additionally, the approach toward corporate entities in AWD dissemination should be reconsidered, with market incentives playing a role. Lastly, promoting larger farmland parcels and increasing large-scale management farmers who are motivated to adopt AWD is essential. These strategies constitute this study’s original contribution. Full article

As described in several recent studies, the appropriation of the concept “religion 宗教” in modern Japan made “Buddhism 仏教” enter a transformation process that led, ultimately, to the reimagining of its very content; according to historian of religions Isomae Junichi, one of these elements was, for instance, an emphasis on “belief” to the detriment of “practice”. However, in terms of Buddhism’s reframing into the category of “religion”, we should also pay attention to the construction of the idea of “superstition 迷信”, which appears during this time as a concept relative to “belief” or “faith”. Often considered the epitome of this belief-centered version of the dharma, the so-called New Buddhism movement (shinbukkyō undō 新仏教運動) that occurred in the turn of the 20th century played a fundamental role in establishing the concept of “superstition”. This paper focuses on Sakaino Kōyō (境野黄洋 1871–1933), a pioneer of Chinese Buddhist studies in modern Japan and one of the main leaders of the movement. In order to explore the intellectual context that gave birth to such reformist efforts, I explore his ideas during the later 1890s, a period in which he was dedicated to differentiating “belief” from “superstition”. During this time, he emphasized the eradication of “superstition”, arguing that it constituted an unsound element both socially and intellectually. Sakaino offered the idea of “poetical Buddhism” (shiteki bukkyō 詩的仏教), a method for interpreting scripture in general, and segments thereof contemporarily regarded as “superstitious” specifically. This paper situates Sakaino’s contributions to Buddhist reform—analyzed through historical and hermeneutical methods and influenced by liberal Christian theology—within the global discourse on religion and science, while critically examining how his reinterpretations navigated tensions between modern rationality and the preservation of Buddhist truth in Meiji Japan. Full article

Purpose: To elucidate pathogen-specific seasonal patterns in infectious keratitis through a comprehensive long-term analysis of microbiologically proven cases in a Japanese tertiary care center. Methods: This retrospective study analyzed 500 consecutive cases of culture-proven infectious keratitis diagnosed and treated by corneal specialists at Yamaguchi University Hospital between 2009 and 2021. Seasonal distribution patterns were analyzed for each pathogen category and specific microorganisms. Results: Among the 500 cases, bacteria were identified in 249 eyes (49.8%), viruses in 173 eyes (34.6%), fungi in 51 eyes (10.2%), and Acanthamoeba in 27 eyes (5.4%). The top 10 causative microorganisms constituted 80.4% of all cases. Distinct seasonal patterns emerged: bacterial keratitis peaked during winter months (October–March), Pseudomonas aeruginosa infections clustered in late summer (August–September), Acanthamoeba keratitis showed summer predominance (June–August), and HSV keratitis was most frequent in winter to spring (January–May). Overall incidence peaked from January to March and reached its nadir in June. Conclusions: This long-term study revealed distinct seasonal patterns for specific pathogens causing infectious keratitis in Japan. The findings suggest that geographical location and climate may influence the temporal distribution of corneal infections. These pathogen-specific seasonal trends could aid in the preliminary diagnosis and empirical treatment of infectious keratitis. Full article

The accelerated growth of the global economy has given rise to a multitude of environmental concerns that demand immediate attention. At this juncture, the total global carbon emissions are exhibiting a gradual increase. China, the United States, India, Russia, and Japan represent the top five countries in terms of global carbon emissions, collectively accounting for approximately 60% of the global total. Of these, China’s carbon emissions are the highest in the world, representing over 30% of the global total. As urbanization accelerates, the carbon emissions from urban agglomerations constitute a substantial share of the nation’s total emissions, rendering the carbon emissions of urban clusters a critical issue. In the context of China’s urban agglomerations, the Beijing–Tianjin–Hebei region, due to factors such as industrial structure, accounts for a relatively high proportion of carbon emissions, approximately 11% of the national total. The future trajectory of carbon emissions in the Beijing–Tianjin–Hebei region will significantly impact the high-quality development of the entire urban cluster. Consequently, research on carbon emissions in the Beijing–Tianjin–Hebei region is of vital importance. This paper takes the carbon emissions of the power industry in the Beijing–Tianjin–Hebei region as the research subject, analyzes its carbon emissions status, and builds a multi-regional input–output model for the Beijing–Tianjin–Hebei region based on the input–output tables and carbon emissions data of each province. This study explores the key influencing factors of carbon emissions from the power industry in this region from 2012 to 2017 and analyzes the carbon emissions transfer and structural evolution from the perspective of the region and the industry to clarify the carbon reduction responsibilities of the Beijing–Tianjin–Hebei region and provide references and recommendations for the formulation of regional collaborative emission reduction policies. The results show that the direct carbon emissions from the power industry in the Beijing–Tianjin–Hebei region account for a higher proportion compared to the indirect carbon emissions it generates by driving other industries. Industries with relatively high indirect carbon emissions in the key path include coal mining and selection, equipment manufacturing, transportation, services, etc. The capital input process from Tianjin and Hebei to Beijing is accompanied by a relatively high carbon transfer. Promoting the widespread adoption of carbon emission reduction technologies will have an effective suppressive effect on carbon emissions in the Beijing–Tianjin–Hebei region, especially in Hebei; Beijing and Tianjin should pay attention to the stimulating effect of increased final demand on carbon emissions; the transfer of carbon emissions between regions and industries shows a downward trend as the power sector undergoes transformation. Full article

Mutations in TSC1 or TSC2 in axons induce tuberous sclerosis complex. Neurological manifestations mainly include epilepsy and autism spectrum disorder (ASD). ASD is the presenting symptom (25–50% of patients). ASD was observed at significantly higher frequencies in participants with TSC2 than those with TSC1 mutations. The occurrence of TSC2 mutations is about 50% larger than TSC1. Therefore, ASD may develop due to TSC2 deficiency. TSC2 regulates microRNA biogenesis and Microprocessor activity via GSK3β. Of reference, everolimus has the best treatment target because of the higher potency of interactions with mTORC2 rather than rapamycin. Mutations in the TSC1 and TSC2 genes result in the constitutive hyperactivation of the mammalian target of the rapamycin (mTOR) pathway, contributing to the growth of benign tumors or hamartomas in various organs. TSC2 mutations were associated with a more severe phenotypic spectrum than TSC1 mutations because of the inhibition of the mTOR cascade. There are few studies on the peptide analysis of this disorder in relation to everolimus. Only one study reported that, in ten plasma samples, pre-melanosome protein (PMEL) and S-adenosylmethionine (SAM) were significantly changed as diagnostic prognostic effects. Our study on peptide analysis in Protosera Inc (Osaka, Japan) revealed that three peptides that were related to inflammation in two patients with tuberous sclerosis, who showed a 30% decrease in ASD symptoms following everolimus treatment. TSC2 mutations were associated with a more severe phenotypic spectrum due to the inhibition of the mTOR cascade. PMEL and SAM were significantly changed as diagnostic effects. Full article

This paper explores the scholarly discourse on the divinity of the emperor in postwar Japan to better understand Japanese conservative nationalism, which has been regaining momentum since the 1990s. Viewing the idea of the divinity of the emperor as ideologically fundamental to Japanese conservative nationalism, this paper looks at how conservative scholars from the 1970s developed a culturalist argument for the divinity of the emperor, first to negate the “humanity declaration”, i.e., the New Year’s greeting by the Showa emperor on 1 January 1946 renouncing his divinity, and then to reconfigure conservative ideology into a popular discourse on Japanese identity (i.e., the Nihonjin-ron), thereby making it more easily accepted by postwar society. Key to this culturalist argument is an essentialized dichotomy between Japanese culture and Western culture, more specifically a binary between Shinto kami and the Christian God—that the Japanese concept of kami is qualitatively different from that of the Christian God, so the emperor is not God but is kami; therefore, the emperor’s divinity is not really denied and he remains the spiritual pillar of the Japanese nation even under the postwar constitutional regime. Refashioning itself as part of the increasingly popular but depoliticized Nihonjin-ron discourse, the culturalist argument on the divinity of the emperor helped make the imperial house a popular topic of the discourse on Japanese identities, even while it completely circumvented the very issues of war responsibility and historical memory which gave rise to the “humanity declaration” in 1946 in the first place. In its depoliticized, popularly appealing form, the culturalist argument played a role in legitimating the regressive conservative nationalism that seeks to revive the pre-1945 divine emperor-centered political regime. Exploring the scholarly discourse on the divinity of the emperor, then, helps shed light on how and why conservative nationalism could persist and gain momentum in the 21st century. Full article

The Zhao Lun, authored by Seng Zhao, elaborates on the Madhyamaka thought. This work has had a significant impact on Chinese Buddhist philosophy, as well as on Confucianism and Taoism. During the Yuan dynasty (1271–1368), the esteemed monk Wencai from the Huayan school of Buddhism composed a book titled A New Commentary on the Zhao Lun (hereafter New Commentary), which offers annotations and explanations for the text of the Zhao Lun and employs the “One Mind” theory to interpret the Zhao Lun. Text analysis methods are utilized in this article to conduct an in-depth study of the “One Mind” theoretical system constructed by Wencai within the New Commentary. It explores the essential content, integrative characteristics, and theoretical origins of the “One Mind” theory, thereby revealing the theoretical style of the Huayan school during the Yuan dynasty from a novel and unique perspective. Additionally, we analyze how Wencai integrates Tathāgatagarbha thought and Madhyamaka thought into his theory of “One Mind”. This analysis constitutes, to a certain extent, an indirect refutation of the harsh criticisms of Tathāgatagarbha thought of “Critical Buddhism” in Japan and provides new perspectives and reflections for a deeper understanding of Tathāgatagarbha thought. Full article

Background: Japan is a country often subject to natural disasters, influenced by a rapidly increasing aging demographic. The current research aims to analyze the food distribution for elderly evacuees who were relocated to a care facility in Wajima City, administered by the non-profit organization Tokushukai Medical Assistant Team (TMAT), post the Noto Peninsula Earthquake on 1 January 2024. A significant portion of the shelter’s inhabitants were elderly individuals. Methods: TMAT’s operations began immediately after the calamity, concentrating on evaluating the nutritional content of meals provided during the initial and subsequent phases, along with a thorough nutritional assessment. During this process, researchers examined the meal conditions for evacuees, including the elderly and those with disabilities, observed the actual meal distribution at welfare centers, and discussed the challenges and potential solutions. Result: Throughout the TMAT mission, a total of 700 evacuees received assistance, with 65% being 65 years old or above. An analysis of the nutritional content of the 10 meal varieties served at the shelter revealed inadequate energy and protein levels for elderly individuals, particularly men, indicating the need for future enhancements. Conclusions: Following a detailed evaluation of TMAT’s response to the Noto Peninsula earthquake, it was determined that the food provided in the shelters in the affected areas did not meet the nutritional needs of elderly individuals, especially men, based on nutritional analysis. To stress the importance of establishing an effective framework, it is recommended to promptly revise the emergency food provisions for the elderly population, considering they constitute the majority of the affected individuals. Full article

Numerous risk factors play a role in the causation of stroke, and the cardiometabolic condition is a one of the most important. In Korea, various treatment methods are employed based on the constitutional type, which is known to differ significantly in cardiometabolic disease. In this study, we compared the estimates obtained for different groups by applying the Mendelian randomization method to investigate the causal effects of genetic characteristics on stroke, according to constitutional type. In clinical analysis, the subtypes differ significantly in diabetes or dyslipidemia. The genetic association estimates for the stroke subtype risk were obtained from MEGASTROKE, the International Stroke Genetics Consortium (ISGC), UKbiobank, and BioBank Japan (BBJ), using group-related SNPs as instrumental variables. The TE subtypes with higher risk of metabolic disease were associated with increased risk (beta = 4.190; s.e. = 1.807; p = 0.035) of cardioembolic stroke (CES), and the SE subtypes were associated with decreased risk (beta = −9.336, s.e. = 1.753; p = 3.87 × 10⁻⁵) of CES. The findings highlight the importance of personalized medicine in assessing disease risk based on an individual’s constitutional type. Full article

Hereditary transthyretin amyloidosis (hATTR) with polyneuropathy (formerly known as Familial Amyloid Polyneuropathy (FAP)) is an endemic amyloidosis involving the harmful aggregation of proteins, most commonly transthyretin (TTR) but sometimes also apolipoprotein A-1 or gelsolin. hATTR appears to be transmitted as an autosomal dominant trait. Over 100 point mutations have been identified, with the Val30Met substitution being the most common. Yet, the mechanism of pathogenesis and the overall origin of hATTR remain unclear. Here, we argue that hATTR could be related to harmful metal exposure. hATTR incidence is unevenly distributed globally, and the three largest defined clusters exist in Japan, Portugal, and Sweden. All three disease regions are also ancient mining districts with associated metal contamination of the local environment. There are two main mechanisms for how harmful metals, after uptake into tissues and body fluids, could induce hATTR. First, the metals could directly influence the expression, function, and/or aggregation of the proteins involved in hATTR pathology. Such metal–protein interactions might constitute molecular targets for anti-hATTR drug design. Second, metal exposure could induce hATTR -associated genetic mutations, which may have happened several generations ago. These two mechanisms can occur in parallel. In conclusion, the possibility that hATTR could be related to metal exposure in geochemically defined regions deserves further attention. Full article

The global tobacco epidemic, claiming over 8 million lives annually, constitutes a formidable public health threat. Fatalities arise from both direct tobacco use and exposure to second-hand smoke. Smoking prevalence, notably in Japan, varies across age groups with distinct patterns indicating higher rates among those aged 40 years and above. Persistent concerns surround the significance of smoking behavior in individuals aged 20 to 30 years, given the potential for early adulthood behavior to contribute to long-term health impacts. The emergence of heated tobacco products adds complexity with a substantial percentage of individuals aged 20 to 30 years using these alternatives. This study analyzed data from 15,333 individuals aged 20 to 39 years, collected through Japan’s “Comprehensive Survey of Living Conditions 2017”. Compliant with the Japan Statistics Act, a secondary analysis employed multivariate logistic analysis to examine concerns and stress sources by sex and smoking behavior, adjusting for various variables. As a result, no statistically significant associations were found between smoking in men and concerns or stress. However, in women who smoked, significant associations were observed between smoking and specific stressors, such as work-related concerns, financial stress, and stress from a lack of personal free time. This study emphasizes the necessity of considering gender differences and social backgrounds in designing targeted smoking-prevention programs, aiming to enhance overall health longevity and comprehensively reduce lifelong smoking rates in this demographic. Full article

Landslides and flash floods are significant natural hazards with substantial risks to human settlements and the environment, and understanding their interconnection is vital. This research investigates the hazards of landslides and floods in two adopted basins in the Yamaguchi and Shimane prefectures, Japan. This study utilized ten environmental variables alongside categories representing landslide-prone, non-landslide, flooded, and non-flooded areas. Employing a machine-learning approach, namely, a LASSO regression model, we generated Landslide Hazard Maps (LHM), Flood Hazard Maps (FHM), and a Composite Hazard Map (CHM). The LHM identified flood-prone low-lying areas in the northwest and southeast, while central and northwest regions exhibited higher landslide susceptibility. Both LHM and FHM were classified into five hazard levels. Landslide hazards predominantly covered high- to moderate-risk areas, since the high-risk areas constituted 38.8% of the study region. Conversely, flood hazards were mostly low to moderate, with high- and very high-risk areas at 10.49% of the entire study area. The integration of LHM and FHM into CHM emphasized high-risk regions, underscoring the importance of tailored mitigation strategies. The accuracy of the model was assessed by employing the Receiver Operating Characteristic (ROC) curve method, and the Area Under the Curve (AUC) values were determined. The LHM and FHM exhibited an exceptional AUC of 99.36% and 99.06%, respectively, signifying the robust efficacy of the model. The novelty in this study is the generation of an integrated representation of both landslide and flood hazards. Finally, the produced hazard maps are essential for policymaking to address vulnerabilities to landslides and floods. Full article