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Search Results (269)

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Keywords = supportive and psychological cancer care

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20 pages, 1362 KB  
Article
Patient Perspectives on Prostate Cancer Prehabilitation: A Qualitative Study Using the Behaviour Change Wheel to Investigate Barriers and Facilitators to Engagement
by Hannah Harsanyi, Nicole Slot, Ashley J. Housten, Yun Yun Lee, M. Eric Hyndman and Lin Yang
Curr. Oncol. 2026, 33(9), 564; https://doi.org/10.3390/curroncol33090564 - 17 Sep 2026
Abstract
Cancer prehabilitation aims to improve outcomes by helping patients physically and mentally prepare for treatment. This qualitative study aimed to investigate barriers and facilitators to engaging in prostate cancer prehabilitation and create recommendations for designing interventions. Semi-structured interviews were used to explore perspectives [...] Read more.
Cancer prehabilitation aims to improve outcomes by helping patients physically and mentally prepare for treatment. This qualitative study aimed to investigate barriers and facilitators to engaging in prostate cancer prehabilitation and create recommendations for designing interventions. Semi-structured interviews were used to explore perspectives on cancer prehabilitation among men diagnosed with prostate cancer in Alberta, Canada. Interviews were thematically analyzed to identify barriers and facilitators to engagement. Themes were mapped to the Behaviour Change Wheel (BCW) to create recommendations for intervention development. Thirty-four men diagnosed with prostate cancer completed interviews. Key facilitators to engaging in prehabilitation included opportunities for social connection, strategies to reduce treatment-related side effects, and support coping with the psychological impact of diagnosis. Barriers included competing care priorities, lack of familiarity with prehabilitation, logistical challenges, and stigmatized perceptions of help-seeking. To promote improved patient engagement, prehabilitation interventions should be initiated near diagnosis, offer personalized, goal-oriented interventions with multiple components, and have options for virtual participation to increase accessibility. These recommendations may help improve the uptake and impact of prehabilitation programming in prostate cancer care. Further research to identify evidence-based interventions for mitigating treatment-related side effects may help increase patient motivation to engage in cancer prehabilitation. Full article
(This article belongs to the Section Genitourinary Oncology)
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27 pages, 1422 KB  
Systematic Review
Effects of Remotely Delivered Yoga Interventions on Quality of Life and Symptom Burden in Women with Breast Cancer: A Systematic Review and Meta-Analysis
by Federica Valeriani, Francesca Gallè, Giulia Scalese, Romy Angela Valia, Marco Ferrante, Daniela Marotta, Andrea Botticelli, Monica Verrico and Carmela Protano
Healthcare 2026, 14(18), 3040; https://doi.org/10.3390/healthcare14183040 - 16 Sep 2026
Abstract
Background/Objectives: Breast cancer (BC) survivors frequently experience persistent psychological and physical symptoms and reduced health-related quality of life (HRQoL). Yoga has emerged as a promising supportive intervention in this context; however, evidence regarding remotely delivered yoga programs remains limited. This systematic review aimed [...] Read more.
Background/Objectives: Breast cancer (BC) survivors frequently experience persistent psychological and physical symptoms and reduced health-related quality of life (HRQoL). Yoga has emerged as a promising supportive intervention in this context; however, evidence regarding remotely delivered yoga programs remains limited. This systematic review aimed primarily to evaluate the effects of remotely delivered yoga interventions on HRQoL among women with BC. Secondary outcomes included psychological and physical symptoms, as well as feasibility, adherence, and safety. Methods: Randomized controlled trials (RCTs) and non-randomized studies assessing remote, home-based, or hybrid yoga interventions delivered through digital platforms, videos, or remote support were searched in PubMed, Scopus, Web of Science, and the Cochrane Library (PROSPERO registration number: CRD420261362619). Methodological quality was assessed using the Joanna Briggs Institute (JBI) critical appraisal tools. A random-effects meta-analysis was performed for HRQoL outcomes from independent RCT populations, using standardized mean differences (Hedges’ g). Results: Twenty-six publications representing 19 independent study cohorts were included. Eighteen publications reported randomized controlled trials and eight reported non-randomized studies. In the meta-analysis, the 9 RCTs that reported effects on HRQoL showed a moderate improvement in this outcome (Hedges’ g = 0.56, 95% CI 0.17–0.96), with substantial between-study heterogeneity (I2 = 72.4%). Secondary psychological and physical outcomes showed potential benefits, but findings varied across studies. Feasibility and adherence were generally favorable, while no serious yoga-related adverse events were reported among studies assessing safety. Conclusions: Remote and home-based yoga interventions may improve HRQoL in women with BC; however, the consistency and generalizability of this effect are limited by substantial between-study heterogeneity and variability in intervention delivery. Further standardized and adequately powered RCTs are needed to confirm clinical effectiveness and inform long-term implementation in breast cancer care. Full article
(This article belongs to the Special Issue Future Trends of Physical Activity in Health Promotion)
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14 pages, 2599 KB  
Article
Self-Reported Late Effects, Information Needs, and Preferences for Long-Term Follow-Up Care Among Survivors of Childhood Cancer: A Nationwide Survivor-Led Survey from Germany
by Jette Luedersen, Bjoern Hessing, Marie Alfes, Franziska E. Marquard and Eva-Maria Wild
Cancers 2026, 18(18), 2951; https://doi.org/10.3390/cancers18182951 - 12 Sep 2026
Viewed by 380
Abstract
Background: Rising survival rates have created a growing population of childhood cancer survivors (CCSs) who have an increased risk of late effects and require long-term follow-up (LTFU) care. Existing services are often fragmented and may not reflect survivors’ priorities; optimizing such care [...] Read more.
Background: Rising survival rates have created a growing population of childhood cancer survivors (CCSs) who have an increased risk of late effects and require long-term follow-up (LTFU) care. Existing services are often fragmented and may not reflect survivors’ priorities; optimizing such care requires understanding not only the self-reported burden of late effects and their impact on daily lives but also survivors’ information status and their preferences for future care. Methods: Survivor Deutschland e.V. conducted a nationwide cross-sectional online survey assessing the current late effects, daily-life impairments, subjective information statuses, current follow-up structures, and preferences for future LTFU care. A total of 339 CCSs were included, covering all childhood cancer entities, most frequently leukemia (30.7%), central nervous system tumors (18.3%), and lymphoma (16.5%). Data were analyzed descriptively and supplemented by paired non-parametric analyses. Results: Overall, 74.3% (252/339) reported at least one late effect. Self-rated limitations in daily life had a median of five (Q1–Q3 3–7) on a 1–10 scale, which increased with the number of reported late effects. The most frequently affected domains were endocrine (36.3%, n = 123), fertility (33.6%), psychological (30.4%, n = 103), neurocognitive (26.0%, n = 88), and orthopedic (24.8%, n = 84) problems. A majority (69.3%, n = 235) knew that late effects existed yet felt insufficiently informed, and 4.4% only learned of these through the survey. Among 172 survivors in adult follow-up care, only 26.8% (46/172) reported access to structured, specialized LTFU care, whereas 56.4% (97/172) preferred this model. Survivors rated the importance of LTFU care highly (median 9/10) but rated satisfaction with their current care as much lower (median 3/10). The most valued components were the coverage of follow-up costs, sufficient consultation time, a dedicated contact person, and clear communication of results. Psychological support was a notable gap (5.8%, 10/172 current access vs. 17.9% 31/172 preferred), and 84.1% were willing to travel up to two hours or more for high-quality care. Conclusions: German CCSs report a high late-effect burden, meaningful impairment of their daily lives, a pronounced information gap, and substantial unmet care needs. These patient-centered findings support structured, risk-adapted LTFU with proactive information, integrated psychological support, and sustainable financing at specialized LTFU centers. Full article
(This article belongs to the Special Issue Survivorship Following Childhood, Adolescent, and Young Adult Cancer)
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15 pages, 3549 KB  
Article
Post-Treatment Nutrition and Rehabilitation Support Is Associated with Reduced Psychological Distress After Early-Stage Upper Gastrointestinal Cancer Surgery: A Retrospective Cohort Study
by Mehmet Kadir Bartın and Müge Kara
Healthcare 2026, 14(18), 2936; https://doi.org/10.3390/healthcare14182936 - 10 Sep 2026
Viewed by 127
Abstract
Background/Objectives: Curative-intent surgery for early-stage upper gastrointestinal (GI) cancer causes substantial nutritional, functional, and psychological morbidity; whether an integrated post-treatment nutrition and rehabilitation pathway improves distress and survival is unclear. Methods: We conducted a retrospective cohort study of 130 patients undergoing curative-intent esophagectomy [...] Read more.
Background/Objectives: Curative-intent surgery for early-stage upper gastrointestinal (GI) cancer causes substantial nutritional, functional, and psychological morbidity; whether an integrated post-treatment nutrition and rehabilitation pathway improves distress and survival is unclear. Methods: We conducted a retrospective cohort study of 130 patients undergoing curative-intent esophagectomy or gastrectomy for early-stage esophagogastric cancer: 65 received a structured post-treatment nutrition and rehabilitation support program (Group A), and 65 received standard care (Group B). The primary outcome was psychological distress trajectory over 12 months (Distress Thermometer; secondarily HADS); overall survival was secondary. Propensity-score matching assessed covariate balance; a multivariable Cox model estimated the adjusted mortality association. Results: Distress scores were similar at 1 month (7.2 vs. 7.4; p = 0.43) and diverged progressively (group × time interaction p < 0.001; 4.9 vs. 6.1 at 12 months; p < 0.001, Cohen’s d ≈ 0.8; 95% CI for the 12-month between-group difference 0.65–1.75 points); HADS-A and HADS-D followed a concordant trajectory (8.4 vs. 10.1; 7.7 vs. 9.3; both p ≤ 0.003). Baseline covariates were reasonably balanced before matching (all standardized mean differences [SMDs] < 0.16) and met the prespecified <0.10 balance threshold for most covariates after matching. Fourteen deaths occurred (3 vs. 11); log-rank testing showed a significant survival difference (p = 0.021), consistent after matching (p = 0.037), and in the adjusted Cox model, support-program receipt was associated with lower mortality (hazard ratio 0.25, 95% CI 0.07–0.90; p = 0.034), though underpowered (14 vs. ~37 events required) and hypothesis-generating. Conclusions: Structured post-treatment nutrition and rehabilitation support was associated with markedly lower psychological distress, the prespecified primary outcome, with the achieved sample exceeding the a priori requirement for the assumed effect size; a secondary, exploratory survival association requires prospective confirmation. These findings support prospective, multicenter evaluation of integrated psycho-oncology and nutrition-rehabilitation care pathways after upper GI cancer surgery and should not be interpreted as demonstrating a causal treatment effect. Full article
(This article belongs to the Section Mental Health and Psychosocial Well-being)
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16 pages, 275 KB  
Article
From Availability to Access: A Mixed-Methods Study of Digital Prostate Cancer Survivorship Support for Black Men
by Olamide Okedara, Gabriela Ilie, Maren Brodovsky, Ross J. Mason, Ricardo Rendon, Andrea Kokorovic, Greg Bailly, Howard Evans, Kunal Jana, Jasmir G. Nayak, Ernest Chan, Stanley Flax, Nikhilesh Patil, David Bowes, Duvern Ramiah, Shingai Mutambirwa, Andrew Oberholzer, Lola Riley, Jordan Cole, William Carruthers, Sarah Taylar and Robert David Harold Rutledgeadd Show full author list remove Hide full author list
Curr. Oncol. 2026, 33(9), 543; https://doi.org/10.3390/curroncol33090543 - 9 Sep 2026
Viewed by 152
Abstract
Introduction: Black men experience persistent disparities across the prostate cancer continuum, including inequities in access to survivorship support. This study examined the perceived value, acceptability, and experiences of accessing a multicomponent digital survivorship program among Black men with prostate cancer. Methods: This exploratory [...] Read more.
Introduction: Black men experience persistent disparities across the prostate cancer continuum, including inequities in access to survivorship support. This study examined the perceived value, acceptability, and experiences of accessing a multicomponent digital survivorship program among Black men with prostate cancer. Methods: This exploratory mixed-methods study was embedded within the ongoing international Phase 4 implementation trial of the Prostate Cancer Patient Empowerment Program (PC-PEP), a six-month digital intervention integrating exercise, pelvic floor muscle training, nutrition, stress management, psychosocial support, and peer connection. Fourteen self-identified Black participants contributed six-month program evaluation and qualitative data collected through open-ended responses and conference-based focus group discussions. Nine participants (64%) had undergone surgery with or without radiation and/or hormone therapy, four (29%) had received radiation with or without hormone therapy, and one (7%) was on active surveillance or had received no treatment. Quantitative data were summarized descriptively, and qualitative data were analyzed using inductive thematic analysis. Results: PC-PEP was highly valued, with median ratings of 10 (IQR 8–10) for likelihood of recommending the program and 9 (IQR 8–10) for overall usefulness. Among participants with available item-level data, 11/13 (85%) reported lifestyle improvement and 12/13 (92%) endorsed offering PC-PEP as standard care. Qualitative findings identified the value of holistic survivorship support, peer connection, normalization of vulnerability, and support for physical and psychological self-management. Participants also described limited awareness of PC-PEP at diagnosis and reliance on individual clinicians or incidental opportunities to learn about the program. Participants emphasized the need for earlier referral, greater representation, and culturally relevant community outreach. Conclusions: Black men who accessed PC-PEP reported high perceived value and identified benefits across multiple dimensions of survivorship. Their experiences, however, highlighted an important distinction between program availability and meaningful access: participants’ experiences suggest that availability alone may not ensure timely connection to survivorship support. Earlier referral, culturally responsive outreach, and integration of survivorship support into routine prostate cancer care may help close this gap. Full article
(This article belongs to the Section Palliative and Supportive Care)
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33 pages, 1656 KB  
Review
Lung Cancer Survivorship: Challenges and Care Needs
by Massimiliano Cani, Paolo Cotogni, Alessandra Greco, Giacomo Ronconi, Elisa Lombardi, Matteo Fracchiolla, Stefania Vallone, Maria Vittoria Pacchiana, Irene Capizzi, Valentina Bertaglia, Simona Carnio, Luisella Righi, Maurizio Balbi, Lorenzo Belluomini, Paolo Bironzo and Silvia Novello
Cancers 2026, 18(17), 2856; https://doi.org/10.3390/cancers18172856 - 3 Sep 2026
Viewed by 554
Abstract
Advances in lung cancer treatment have progressively improved survival across all disease stages. Some patients now achieve long-term survival, while others may remain on treatment for several years, particularly with immune checkpoint inhibitors and selected tyrosine kinase inhibitors. These advances have increased recognition [...] Read more.
Advances in lung cancer treatment have progressively improved survival across all disease stages. Some patients now achieve long-term survival, while others may remain on treatment for several years, particularly with immune checkpoint inhibitors and selected tyrosine kinase inhibitors. These advances have increased recognition of the survivorship needs of patients with lung cancer, including persistent symptoms, treatment-related toxicities, and social, psychological, and caregiver-related concerns. The integration of palliative care has also become increasingly relevant, reflecting a shift in the traditional care paradigm by extending supportive approaches beyond the end-of-life setting to patients living long-term with active disease. However, evidence and care models addressing lung cancer survivorship remain fragmented and focus predominantly on patients treated with curative intent. This narrative review provides a comprehensive overview of survivorship in lung cancer, from screening and early-stage to locally advanced and metastatic disease, while also examining more cross-cutting physical, psychological and social domains. Greater recognition and systematic assessment of these needs is essential to develop structured, coordinated, and personalized survivorship pathways for the growing and clinically heterogeneous population of individuals living with and beyond lung cancer. Full article
(This article belongs to the Section Cancer Survivorship and Quality of Life)
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14 pages, 3539 KB  
Article
Spiritual Well-Being, Religiosity, Psychological Distress and Quality of Life in Adults with Cancer: A Cross-Sectional Study in a Romanian Oncology and Palliative Care Centre
by Dana Sonia Nagy, Alexandru Catalin Motofelea, Sorin Saftescu, Vlad-Norin Vornicu, Razvan Gheorghe Diaconescu, Dan Ionel Orbulescu, Catalin Alexandru Pirvu and Serban Mircea Negru
Cancers 2026, 18(17), 2840; https://doi.org/10.3390/cancers18172840 - 2 Sep 2026
Viewed by 287
Abstract
Background: Spiritual wellbeing is increasingly recognised as a key area of complex oncology and palliative care, but evidence from Eastern Europe is still limited. Understanding how spiritual well-being and religiosity are related to psychological distress and quality of life can inform holistic support [...] Read more.
Background: Spiritual wellbeing is increasingly recognised as a key area of complex oncology and palliative care, but evidence from Eastern Europe is still limited. Understanding how spiritual well-being and religiosity are related to psychological distress and quality of life can inform holistic support interventions in cancer patients. Objective: To describe spiritual well-being, religiosity, anxiety, depression, and quality of life in a Romanian cancer cohort, and to examine associations between spiritual well-being and psychological distress. Methods: A cross-sectional study was carried out in 124 cancer-stricken adults at a regional cancer centre in Romania. Participants completed FACIT-Sp-12 (spiritual well-being), RCI-10 (religious belief), HADS (depression), and EQT QLQ-C30 (QoL). Multivariable linear regression was used to determine independent predictors of outcomes in patients. Results: Participants had a median age of 65 years (53–71) and 70 (56%) patients had metastatic disease. Religious involvement was high and spirituality related to disease was commonly reinforced, with 66 (53%). There were twice as many cases of clinical depression symptoms (28%) as anxiety symptoms (14%). A median QoL score of 51 (IQR: 37–64 points) was revealed by descriptive analysis of the EORTC QLQ-C30. In adjusted multivariable models, spiritual well-being was significantly and independently associated with lower anxiety (β = −0.25, p = 0.030) and depression (β = −0.29, p = 0.013), with models accounting for 11.5% and 10.8% of variance, respectively. Global quality of life was best explained by the model (R2 = 26.4%), with independent contributions from impaired ECOG performance status (β = −0.27, p = 0.006) and depressive symptoms (β = −0.22, p = 0.014), whereas religious commitment showed no independent association with any primary outcome. Conclusions: In this Romanian cohort, spiritual well-being, not religious adherence, remained independently associated with lower anxiety and depression, suggesting that spiritual well-being is associated with better psychological health among cancer patients. Religious affiliation has not been shown to be independent of any outcome, a difference with direct implications for the screening of spiritual care. Global quality of life, on the other hand, was independently associated with both physical functional status (ECOG) and depressive symptom burden, rather than with spiritual or religious factors, underlining that both functional decline and psychological distress remain central to cancer-related quality of life. Full article
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22 pages, 1516 KB  
Article
Associations Between Cancer-Related Self-Efficacy, Coping Styles, and Perceived Stress in Patients with Lung Cancer: A Cross-Sectional Mediation Analysis
by Agata Poręba-Chabros, Magdalena Kolańska-Stronka and Marzanna Farnicka
J. Clin. Med. 2026, 15(17), 6674; https://doi.org/10.3390/jcm15176674 - 28 Aug 2026
Viewed by 246
Abstract
Lung cancer carries a substantial psychosocial burden, frequently involving elevated psychological distress, disease-related stigma, and difficulties in adaptation to illness. Coping styles and self-efficacy are both recognized as relevant personal resources in chronic illness, but their combined statistical association with perceived stress, and [...] Read more.
Lung cancer carries a substantial psychosocial burden, frequently involving elevated psychological distress, disease-related stigma, and difficulties in adaptation to illness. Coping styles and self-efficacy are both recognized as relevant personal resources in chronic illness, but their combined statistical association with perceived stress, and specifically whether self-efficacy accounts for part of the association between coping and stress, has not been examined in lung cancer patients. Objective: This study examined the statistical associations between coping styles (task-, emotion-, and avoidance-oriented), cancer-related self-efficacy, and perceived stress, testing cancer-related self-efficacy as a mediator of each coping style’s association with perceived stress, and additionally compared these variables by gender. Methods: A cross-sectional study was conducted among ninety-seven patients diagnosed with lung cancer. Standardized measures included the Coping Inventory for Stressful Situations, a cancer-specific adaptation of the Generalized Self-Efficacy Scale, and the Perceived Stress Scale. A series of three simple mediation analyses was performed to evaluate the proposed statistical model. Results: Task-oriented coping was positively, and emotion-oriented coping negatively, associated with cancer-related self-efficacy; avoidance-oriented coping showed no significant association with self-efficacy. Task- and emotion-oriented coping were significantly associated with perceived stress in the expected directions, while avoidance-oriented coping was not. Cancer-related self-efficacy significantly, and partially, mediated the association between task-oriented coping and perceived stress; no significant indirect effect was found for emotion- or avoidance-oriented coping. Women reported significantly higher perceived stress and greater use of emotion-oriented coping than men, with no significant gender differences in self-efficacy or the other coping styles. Conclusions: In this cross-sectional sample, cancer-related self-efficacy was statistically associated with lower perceived stress specifically through its association with task-oriented coping, whereas the association between emotion-oriented coping and stress appeared largely independent of self-efficacy. These findings suggest that coping styles are associated with perceived stress through at least partly distinct mechanisms and support attention to both active coping and self-efficacy beliefs in psychosocial care for lung cancer patients, while findings regarding gender differences warrant further, formally tested investigation. Full article
(This article belongs to the Section Mental Health)
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17 pages, 279 KB  
Article
Longitudinal Changes in Illness Acceptance, Psychological Adjustment, and Quality of Life After Robot-Assisted Radical Prostatectomy
by Adrianna Królikowska, Kamila Rachubińska, Mariusz Panczyk, Marzena Mikła, Anna Maria Cybulska, Marta Nowak, Elżbieta Grochans and Daria Schneider-Matyka
Cancers 2026, 18(17), 2774; https://doi.org/10.3390/cancers18172774 - 26 Aug 2026
Viewed by 329
Abstract
Background: Prostate cancer is one of the most commonly diagnosed cancers in men. Robot-assisted radical prostatectomy (RARP) is one of the recommended surgical treatment options; however, knowledge regarding changes in illness acceptance, psychological adjustment, and quality of life after surgery remains limited. [...] Read more.
Background: Prostate cancer is one of the most commonly diagnosed cancers in men. Robot-assisted radical prostatectomy (RARP) is one of the recommended surgical treatment options; however, knowledge regarding changes in illness acceptance, psychological adjustment, and quality of life after surgery remains limited. Objective: To evaluate changes in illness acceptance, psychological adjustment, and quality of life in patients undergoing RARP. Materials and Methods: A total of 150 patients diagnosed with prostate cancer and scheduled for RARP were enrolled. Longitudinal analysis was performed in 93 patients who completed both study assessments. Evaluations were conducted before surgery and 3–4 months postoperatively using a self-developed questionnaire, the Acceptance of Illness Scale (AIS), the Mini-Mental Adjustment to Cancer (Mini-MAC), the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (EORTC QLQ-C30), and the prostate cancer-specific module (EORTC QLQ-PR25). Results: Following RARP, illness acceptance did not change significantly after Holm adjustment (pHolm = 0.465). Psychological adjustment showed an adverse postoperative pattern, characterised by increased anxious preoccupation, helplessness–hopelessness, and destructive style, together with reduced fighting spirit and constructive style. After adjustment across 25 paired outcome comparisons, significant increases remained in emotional and cognitive functioning scores, while constipation and diarrhoea decreased significantly. Sexual activity also decreased significantly after surgery. Among participants who completed both assessments, incontinence-aid use increased from 15/93 (16.1%) before surgery to 38/93 (40.9%) at follow-up (exact two-sided McNemar test, p < 0.001). Conclusions: During the early postoperative period following RARP, favourable changes were observed in selected quality-of-life scores, whereas illness acceptance did not change significantly after adjustment for multiple comparisons. At the same time, psychological adjustment showed an adverse pattern, characterised by reduced fighting spirit and constructive style together with increased anxious preoccupation, helplessness–hopelessness, and destructive style. Decreased sexual activity and increased incontinence-aid use further illustrate the multidimensional nature of early postoperative recovery. These exploratory findings indicate that favourable changes in selected quality-of-life outcomes do not necessarily coincide with improved psychological adaptation and support the inclusion of psycho-oncological assessment and support in postoperative care. Full article
(This article belongs to the Section Cancer Survivorship and Quality of Life)
14 pages, 1093 KB  
Review
Lifestyle Interventions During Radiotherapy: A Scoping Review of Their Effects on Toxicity and Patient-Centered Outcomes
by Anastasia Stergioula, Mavra Antiochou-Plexida, Marietina Giannoutsou, Eleni Gotsopoulou, Stamatina Karavopoulou, Ioanna Kitsou, Chrysovalantou Manolopoulou, Maria Pantelidi, Chrysanthi Pontiki and Panagiotis Plotas
Med. Sci. 2026, 14(4), 501; https://doi.org/10.3390/medsci14040501 - 20 Aug 2026
Viewed by 793
Abstract
Background/Objectives: Lifestyle interventions may alleviate treatment-related toxicity and improve patient-centered outcomes during radiotherapy (RT). This scoping review mapped randomized evidence on lifestyle interventions delivered during RT, summarized reported outcomes, and identified evidence gaps. Methods: PubMed and Web of Science were searched [...] Read more.
Background/Objectives: Lifestyle interventions may alleviate treatment-related toxicity and improve patient-centered outcomes during radiotherapy (RT). This scoping review mapped randomized evidence on lifestyle interventions delivered during RT, summarized reported outcomes, and identified evidence gaps. Methods: PubMed and Web of Science were searched for randomized controlled trials (RCTs) published from April 2016 to April 2026. Eligible studies included adults who received exercise, nutritional, psychological, combined, or multimodal lifestyle interventions during their RT treatment. Study characteristics, intervention details, and outcomes were charted and narratively synthesized. Results: Twenty-three RCTs were included. Exercise interventions were evaluated in 12 studies, nutrition in five, psychological in one, combined exercise-and-nutrition in two, combined nutrition-and-psychological in two, and multimodal interventions comprising all three components in one study. Breast, head and neck, and prostate cancers were most frequently represented. QoL, fatigue, and functional capacity were the most commonly assessed outcomes. Exercise interventions were most consistently associated with improvements in fatigue and functional capacity, whereas effects on QoL were less consistent. Nutritional interventions showed favorable findings for nutritional status and treatment-related toxicity. Psychological, combined, and multimodal interventions showed favorable findings for selected QoL, fatigue, nutritional, and psychological outcomes. Key evidence gaps included heterogeneous intervention protocols and outcomes assessment, limited evidence for non-exercise interventions and underrepresentation of several cancer populations. Conclusions: Lifestyle interventions delivered during RT may improve selected patient-centered and treatment-related toxicity outcomes. Exercise comprised the largest body of evidence, whereas other intervention types were less frequently evaluated. Heterogeneity across studies limits conclusions regarding optimal approaches. Further RT-specific studies using standardized intervention programs and comparable outcome measures are required to inform supportive-care delivery. Full article
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17 pages, 278 KB  
Article
Caregiving Experiences, Supportive Care Needs and Coping Strategies Among Family Caregivers of Patients with Colorectal Cancer in Kazakhstan: A Qualitative Descriptive Study
by Gulbakit Koshmaganbetova, Azamat Zharylgapov, Arip Koishybaev, Nauryzbay Imanbayev and Aliya Zhylkybekova
Nurs. Rep. 2026, 16(8), 288; https://doi.org/10.3390/nursrep16080288 - 18 Aug 2026
Viewed by 469
Abstract
Background: Family caregivers play a central role in supporting people with colorectal cancer (CRC) and often manage complex physical, emotional, and practical demands. However, evidence regarding their experiences and supportive care needs in Kazakhstan remains limited. This qualitative study explored caregiving experiences, caregiving [...] Read more.
Background: Family caregivers play a central role in supporting people with colorectal cancer (CRC) and often manage complex physical, emotional, and practical demands. However, evidence regarding their experiences and supportive care needs in Kazakhstan remains limited. This qualitative study explored caregiving experiences, caregiving burden, caregivers’ needs, and coping strategies. Methods: A qualitative descriptive design was used, involving semi-structured interviews with 21 family caregivers caring for patients with CRC. Participants were recruited purposively from the Medical Center of West Kazakhstan Marat Ospanov Medical University and outpatient clinics in Aktobe between December 2025 and March 2026. Interviews were audio-recorded, transcribed verbatim, and analyzed using inductive reflexive thematic analysis. Results: Most family caregivers of patients with colorectal cancer were women (95.2%). Five main themes developed: emotional challenges, transformation of daily life, caregiving tasks, caregivers’ needs and support gaps, and coping strategies and resilience. Diagnosis was described as a distressing experience characterized by shock, fear, and uncertainty. Caregiving substantially disrupted employment, financial stability, and family roles, often requiring work adjustment or leaving the workforce. Caregivers reported insufficient preparation for stoma care and expressed a strong need for structured training. Social isolation was common, as both caregivers and patients experienced a shrinking of their social support networks. Despite substantial burden, caregivers described adaptive responses to ongoing emotional and practical demands, and resilience was a prominent theme. Conclusions: Family caregivers of patients with colorectal cancer in Kazakhstan face interconnected emotional, informational, physical, and system-level challenges, while also drawing on resilience. The findings highlight priorities for support, including structured stoma care education, psychological services, recognition of caregivers’ roles, and improved discharge and transitional care. Full article
(This article belongs to the Section Nursing Care for Older People)
20 pages, 275 KB  
Article
Beyond Treatment: Cancer Survival and Daily Life Among Women with Breast Cancer: A Qualitative Phenomenological Study in La Araucanía, Chile
by Scarlet Hauri-Opazo, Bárbara Burgos-Mansilla, Cinthya Espejo-Alvarado, Ángela Navarrete-González and Ana María Donoso-Rojas
Behav. Sci. 2026, 16(8), 1413; https://doi.org/10.3390/bs16081413 - 18 Aug 2026
Viewed by 270
Abstract
Breast cancer constitutes one of the oncological diagnoses with the greatest impact on women’s lives, with consequences that extend beyond active treatment into a survivorship period marked by profound transformations in identity, relationships, and well-being. This study aimed to explore the impacts that [...] Read more.
Breast cancer constitutes one of the oncological diagnoses with the greatest impact on women’s lives, with consequences that extend beyond active treatment into a survivorship period marked by profound transformations in identity, relationships, and well-being. This study aimed to explore the impacts that breast cancer produces on the everyday lives of survivor women in the municipality of Villarrica, La Araucanía Region. A qualitative methodology with a phenomenological orientation was employed, based on discourse analysis of three focus groups with 20 female breast cancer survivors between 35 and 70 years old. The analysis identified five categories: impact on everyday life and work, management of uncertainty and fear, transformation of self-care and life priorities, support networks and community, and barriers to accessing the healthcare system. The findings demonstrate the coexistence of posttraumatic growth and persistent psychological distress, together with structural inequities that limit access to comprehensive care during the survivorship period. It is concluded that cancer survivorship demands public policy responses that are continuous, multilevel, and integrative of a gender perspective, articulating individual, family, and community interventions from primary healthcare. Full article
(This article belongs to the Section Health Psychology)
51 pages, 18879 KB  
Review
Time Toxicity in Advanced Breast Cancer: Psychological Burden, Psychiatric Vulnerability, and Implications for Patient-Centered Decision-Making
by Giuseppe Marano, Ida Paris, Gianandrea Traversi, Osvaldo Mazza, Silvia Rotondaro, Tatiana D’Angelo, Paola Fuso, Daniela Pia Rosaria Chieffo, Gianluca Franceschini and Marianna Mazza
Medicina 2026, 62(8), 1551; https://doi.org/10.3390/medicina62081551 - 12 Aug 2026
Viewed by 622
Abstract
The paradigm shift toward precision oncology in advanced breast cancer has increased therapeutic complexity, prolonging survival for many patients while simultaneously expanding the temporal burden associated with cancer care. Time toxicity, defined as the cumulative time spent receiving, accessing, coordinating, and recovering from [...] Read more.
The paradigm shift toward precision oncology in advanced breast cancer has increased therapeutic complexity, prolonging survival for many patients while simultaneously expanding the temporal burden associated with cancer care. Time toxicity, defined as the cumulative time spent receiving, accessing, coordinating, and recovering from medical interventions, is increasingly recognized as a clinically meaningful but still under-assessed dimension of patient-centered value. Beyond its organizational and economic implications, time toxicity may exert profound psychological and psychiatric effects, particularly in patients with advanced disease, for whom time represents not only a practical resource but also an existential, relational, and emotional domain. This narrative review examines how objective and subjective dimensions of time toxicity may inform patient-centered decision-making in advanced breast cancer. We summarize current evidence on the temporal demands of cancer care in advanced breast cancer and their psychological and relational consequences, focusing on how these factors can be discussed in patient-centered treatment decisions. From a value-based oncology perspective, the review examines how treatment optimization, subcutaneous formulations, oral therapies, telemedicine-based surveillance, decentralized care models, and early psycho-oncological assessment may reduce non-value-added time in clinical settings while preserving quality of care. Methodological challenges in measuring time toxicity and correlating it with overall survival, health-related quality of life, anxiety, depression, demoralization, and illness-related distress are also discussed. Incorporating time toxicity into shared decision-making may help clinicians move beyond traditional efficacy endpoints. It may support a more comprehensive approach in which survival benefit, psychological well-being, personal priorities, and the subjective value of time are considered together. Full article
(This article belongs to the Special Issue New Developments in Diagnosis and Management of Breast Cancer)
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18 pages, 1293 KB  
Article
“Translational” Patient Education in Adult Cancer Patients with Entero-Urostomy and Their Caregivers: A Qualitative Focus Group Study
by Nicolò Panattoni, Alessia Campoli, Alessandro Spano, Carmelina De Stefano, Daniele De Rossi, Federica Sorrenti, Albina Paterniani, Aurora De Leo, Fabrizio Petrone, Laura Iacorossi and Emanuele Di Simone
Healthcare 2026, 14(16), 2501; https://doi.org/10.3390/healthcare14162501 - 12 Aug 2026
Viewed by 589
Abstract
Background/Objectives: Patient education (PE) is a key component in the management of chronic conditions, including living with an entero-urostomy. Exploring patients’ and caregivers’ experiences may inform the development of tailored educational interventions. This study aimed to explore the perceptions, experiences, and needs [...] Read more.
Background/Objectives: Patient education (PE) is a key component in the management of chronic conditions, including living with an entero-urostomy. Exploring patients’ and caregivers’ experiences may inform the development of tailored educational interventions. This study aimed to explore the perceptions, experiences, and needs of adult oncology patients with entero-urostomies and their caregivers as part of the patient education process. Methods: A descriptive qualitative study was conducted at a single Italian cancer centre using two focus group sessions integrated with PE activities. Discussions were audio-recorded and analysed through thematic analysis following the framework described by Dawadi. NVivo was used to support data management and facilitate the assessment of data saturation. Results: A total of 28 participants (15 patients and 13 caregivers) were recruited. Three main themes emerged: translational patient education as a co-constructed educational process, time as a protective and regulatory resource in everyday stoma management and living with a stoma requires adaptation and meaning-making. The first theme describes a dynamic integration of clinical, peer, and relational knowledge co-constructed by nurses, patients, and caregivers. The second theme referred to the perception of time and care contexts, including telenursing, as protective spaces supporting anticipatory coping and daily life planning. The last theme captured the embodied and psychological adaptation to living with a stoma, characterised by heterogeneous processes of acceptance and meaning-making. Conclusions: PE emerges as a relational and interactive process that supports self-care, emotional adjustment, and quality of life. The concept of translational patient education, as part of the patient education process, offers a novel framework for integrating multiple forms of knowledge within educational practices, strengthening the person-centred nature of PE programmes. These findings support the development of tailored, person-centred PE interventions that incorporate the dynamic educational ecosystem involving patients, caregivers, and stoma care nurses. They also highlight the need for further research to validate this conceptual model across diverse settings and populations. Full article
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27 pages, 864 KB  
Review
Surviving Cancer, Lacking Support: The Hidden Burden of Modern Radiation Oncology in the Treatment of Oligometastatic Disease
by Beth Chasty, Agata Rembielak, Richard Berman and Eva Oldenburger
Cancers 2026, 18(16), 2584; https://doi.org/10.3390/cancers18162584 - 11 Aug 2026
Viewed by 531
Abstract
The management of oligometastatic disease has undergone a significant paradigm shift over the past two decades. Once considered uniformly incurable, selected patients with metastatic disease can now achieve prolonged progression-free survival, durable disease control, and, in carefully selected cases, long-term remission or cure [...] Read more.
The management of oligometastatic disease has undergone a significant paradigm shift over the past two decades. Once considered uniformly incurable, selected patients with metastatic disease can now achieve prolonged progression-free survival, durable disease control, and, in carefully selected cases, long-term remission or cure through metastasis-directed therapies. Advances in stereotactic ablative radiotherapy (SABR), surgery, systemic therapies, and the emerging concept of Curative Oligometastatic Radiotherapy (CORT) have challenged the traditional distinction between curative and palliative treatment. Concurrent developments in imaging, including PET/CT, prostate-specific membrane antigen (PSMA) PET, whole-body MRI, and MR-guided adaptive radiotherapy (MR-linac), together with evolving biomarker research, are improving disease characterisation, refining patient selection, and treatment personalisation. As survival improves, an increasing number of patients are living with durably controlled metastatic cancer and experience long-term physical, psychological, cognitive, functional, and financial consequences of treatment. Despite these challenges, evidence-based survivorship pathways for patients with oligometastatic disease remain poorly defined. Supportive oncology is becoming an essential component of modern radiation oncology rather than an adjunct to cancer treatment. This emerging discipline focuses on optimising symptom control, minimising toxicity, and delivering structured survivorship care. Rather than being limited to end-of-life care, supportive oncology is embedded throughout the patient journey; from diagnosis and treatment selection to prehabilitation, rehabilitation, patient-reported outcome (PRO) monitoring, surveillance for late effects, multidisciplinary follow-up, and long-term survivorship. This review discusses how advances in precision radiotherapy, molecular imaging, biomarkers, and emerging treatment technologies are reshaping the management of oligometastatic disease while simultaneously creating a growing population of long-term survivors with increasingly complex supportive care needs. It highlights the expanding role of supportive oncology in the care of patients with oligometastatic disease, encompassing multidisciplinary symptom management and argues that improvements in disease control must now be matched by the development of evidence-based multidisciplinary survivorship pathways that integrate supportive oncology to optimise quality of life (QoL), functional independence, and patient-centred outcomes. Finally, this review highlights current evidence gaps and proposes future research priorities for developing evidence-based survivorship models for this rapidly expanding patient population. Full article
(This article belongs to the Special Issue Modern Radiation Oncology: Predictions, Prognosis and Survivorship)
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