Search Results (27)

Background/Objectives: Huntington’s disease (HD) is a neurodegenerative disorder involving the basal ganglia and is characterized by psychiatric, cognitive, and movement dysfunction, including gait and balance impairment. Given the limited efficacy of pharmacological treatments for HD motor symptoms, nonpharmacological approaches like rhythmic auditory stimulation are being explored. This study aims to describe walking performance in people with HD during rhythmic auditory stimulation using external musical cues and internal singing cues. Methods: Individuals in the manifest stage of HD performed walking in four conditions: (1) comfortable pace, (2) cognitive dual task, (3) musical cue (music was played aloud), and (4) singing cue (participants sang aloud). Sensors measured cadence, velocity, stride length, and variability. Relationships between change in cadence and motor and cognitive measures were explored. Results: While no direct measurements of synchronization were performed, limiting our interpretation, neither the external musical cue nor the singing cue significantly improved walking performance. Both cues increased variability, similar to what was observed during the dual task. Greater subjective balance confidence and better cognitive performance were associated with positive cadence change during cueing. Conclusions: Musical cues may be too cognitively demanding for individuals with Huntington’s disease as they worsen gait variability without increasing gait speed, cadence, or stride length. Although global cognition and perceived balance confidence were related to the ability to increase cadence, very few people were able to increase their cadence during either cue. Therefore, the results do not support the use of musical cues to improve gait for individuals with Huntington’s disease. Full article

Background and Objectives: Post-stroke aphasia (PSA) severely limits communication and quality of life. This case study explores the impact of an integrated Neurologic Music Therapy (NMT) approach, combining Melodic Intonation Therapy (MIT) and Therapeutic Singing (TS), on language recovery and brain reorganization in a 59-year-old woman with non-fluent motor aphasia following an ischemic stroke. Methods: Over 8 weeks, the patient underwent 24 sessions of MIT alongside standard speech therapy. Language abilities were assessed using the Western Aphasia Battery-Revised, while fMRI scans captured neurophysiological changes pre- and post-intervention. Results: The results showed significant language improvements: spontaneous speech increased by 68.9%, auditory comprehension by 30.8%, and naming by 83.3%. The Aphasia Quotient rose from 39.3 to 61.4, marking a shift from severe to moderate aphasia. Neuroimaging revealed heightened activation in both hemispheres, especially in the superior frontal and parietal regions, supplementary motor area, and superior temporal gyrus. Increased engagement of the limbic system, particularly the paracingulate gyrus, pointed to emotional involvement and widespread cortical reorganization. Conclusions: These findings highlight the effectiveness of integrating MIT and TS with emotionally meaningful music, supporting language recovery and neural plasticity in PSA. Full article

Voice conversion (VC) is an advanced technology that enables the transformation of raw speech into high-quality audio resembling the target speaker’s voice while preserving the original linguistic content and prosodic patterns. In this study, we propose a voice conversion algorithm, Multi-Dimensional Perception Flow Matching (MPFM-VC). Unlike traditional approaches that directly generate waveform outputs, MPFM-VC models the evolutionary trajectory of mel spectrograms with a flow-matching framework and incorporates a multi-dimensional feature perception network to enhance the stability and quality of speech synthesis. Additionally, we introduce a content perturbation method during training to improve the model’s generalization ability and reduce inference-time artifacts. To further increase speaker similarity, an adversarial training mechanism on speaker embeddings is employed to achieve effective disentanglement between content and speaker identity representations, thereby enhancing the timbre consistency of the converted speech. Experimental results for both speech and singing voice conversion tasks show that MPFM-VC achieves competitive performance compared to existing state-of-the-art VC models in both subjective and objective evaluation metrics. The synthesized speech shows improved naturalness, clarity, and timbre fidelity in both objective and subjective evaluations, suggesting the potential effectiveness of the proposed approach. Full article

Background/Objectives: As the global population ages, the need for effective nonpharmacological interventions to support cognitive health has become increasingly urgent. Singing has been identified as a promising strategy to enhance cognitive function and emotional well-being in older adults. While substantial research has focused on the neurocognitive benefits of musical training, the specific effects of singing on neuroplasticity and cognition in aging populations remain underexplored. Methods: This review synthesizes findings from PubMed, PsycINFO, and Google Scholar to examine the impact of singing on cognitive health, particularly in mitigating cognitive decline and promoting mental well-being. Results: Key benefits of singing include improvements in verbal fluency, executive function, and episodic memory. Structural changes such as increased white matter integrity and enhanced auditory–motor integration highlight the potential of singing to stimulate neuroplasticity. Among individuals with dementia, singing fosters episodic memory, mood enhancement, and social connection, while healthy older adults demonstrate improved verbal flexibility and cognitive resilience. However, methodological limitations, such as small sample sizes and cross-sectional designs, preclude definitive conclusions about long-term benefits. Conclusions: Future research should explore the specific neural mechanisms underlying these effects, with an emphasis on longitudinal studies and diverse populations. Tailored, inclusive singing programs could address individual cognitive and physical abilities while fostering sustained engagement and social connection. As a low-cost, scalable intervention, singing holds promise for addressing cognitive and emotional challenges associated with aging, offering an accessible avenue to support healthy aging and enhance quality of life across diverse populations. Full article

In uncertain situations, individuals seek to maximize rewards while managing risks. Yet, the effects of acute stress and anxiety on decision-making in ambiguous and risky contexts are unclear. This study aims to contribute to the exploration of how acute stress influences sensitivity to immediate vs. delayed rewards, risk management strategies, and the role of anxiety in these processes. This study used the laboratory acute stress induction paradigm to analyze the direction of influence of acute stress on ambiguity decision-making and risky decision-making in males and then used moderating effect analysis to study the impact of anxiety on this process. The results show that a combination of the Socially Evaluated Cold Pressor Test and the Sing-a-Song Stress Test can successfully induce acute stress, which reduces both the proportion of the options selected that represent long-term rewards and risk-adjustment ability. Additionally, trait anxiety had a moderating effect on the influence of stress on ambiguity decision-making. Acute stress reduces focus on long-term rewards while increasing focus on short-term rewards, leading to impulsivity and impaired risk-adjustment. Additionally, to some extent, high trait anxiety scores predict better performance in making decisions under ambiguity during stress. Full article

In the past, the Romani in Slovakia identified with the prevailing religion, mainly with the Roman Catholic Church. However, the missionary activities of various Christian denominations after 1990 resulted in the conversion of the Romani to Pentecostal Christian communities. This launched a long, creative process of the formation of Pentecostal Romani music. Romani believers consider music and the ability to play and sing to be a gift from God and view these as a form of prayer that should serve for the praise of God. That is why many have given up their worldly music making and now play only praise songs. They gradually modified the hymns they borrowed and replaced them with their own creations. The soundscape of religion does not lie only in religious singing and music, as the emotional sermons and prayers, glossolalia and sounds during the healing and blessing rituals can also be considered religious sounds. During the worship services, this mixture of various sounds leads to the gradual spiritual and emotional unification of the community. The music and the rituals create feelings of intense sensory and emotional character that reflect in bodily expressions. Movements, dance, and the positions of the hands can help glorify God and experience the worship service more intensely. However, under certain circumstances, they might become sources of temptation and sin. This is related to the concepts of “purity” and “impurity”. The premises, whether sacral or profane, interior or exterior ones, also play a significant role in creating the sound. In writing this paper, I have also drawn on my own research on Romani Christian songs, which I carried out in (2012–2013 in Eastern Slovakia). Full article

A fungal strain (X21156) collected in Tibet was used as the material, identified based on its morphological characteristics and internal transcribed spacer (ITS) sequence; its optimal culture conditions were analyzed by single-factor experiments; artificial domestication and cultivation were carried out; its nutrient composition was determined; and the bioactivities of its polysaccharides were detected using chemical antioxidant assays and MTT assays. The results showed that the strain was Pleurotus citrinopileatus Sing. Its optimal culture conditions were a pH of 7, a temperature of 25 °C, glucose (20 g·L⁻¹) as the carbon source, and yeast powder (20 g·L⁻¹) as the nitrogen source. The fresh weight of a single domesticated fruiting body was 41.16 g. The strain had high protein (28.5%), high fiber (34%), and low fat (1.4%) contents, with high proportions of fresh and sweet amino acids. Polysaccharides had good scavenging ability on ABTS+, DPPH, and OH free radicals (EC₅₀ 0.06 mg/mL, 1.21 mg/mL, and 3.62 mg/mL, respectively), and the cytotoxicity of polysaccharides to hepatocellular carcinoma cells (HepG2) (IC₅₀: 1.69 mg/mL) was higher than that of triple-negative breast cancer cells (MDA-MB-468) (IC₅₀: 1.76 mg/mL). In conclusion, the study provides a reference on the optimal culture conditions, domestication and cultivation, and dietary and medicinal values of wild P. citrinopileatus Sing. Full article

In France, around one-fifth of children have reading difficulties, and school results are highly dependent on their socio-economic status. In this context, the need for alternative and innovative teaching techniques holds importance, and more artistic approaches are promising. The aim of this study was to assess the impact of a daily choral singing or creative writing practice on the cognitive and linguistic development of French children from disadvantaged backgrounds. Eighty children participated in this longitudinal study, for whom we measured several cognitive and linguistic skills at the beginning (pre-test) and end (post-test) of the school year. The results showed that children in “singing” classes improved both their reading skills and processing speed, while those in “writing” classes improved their reading skills and vocabulary. These results open up new avenues of learning support, specifically for children with difficulties. Full article

The development of the central auditory system, including the auditory cortex and other areas involved in processing sound, is shaped by genetic and environmental factors, enabling infants to learn how to speak. Before explaining hearing in humans, a short overview of auditory dysfunction is provided. Environmental factors such as exposure to sound and language can impact the development and function of the auditory system sound processing, including discerning in speech perception, singing, and language processing. Infants can hear before birth, and sound exposure sculpts their developing auditory system structure and functions. Exposing infants to singing and speaking can support their auditory and language development. In aging humans, the hippocampus and auditory nuclear centers are affected by neurodegenerative diseases such as Alzheimer’s, resulting in memory and auditory processing difficulties. As the disease progresses, overt auditory nuclear center damage occurs, leading to problems in processing auditory information. In conclusion, combined memory and auditory processing difficulties significantly impact people’s ability to communicate and engage with their societal essence. Full article

To date, no established protocol exists for measuring functional voice changes in singers with subclinical singing-voice complaints. Hence, these may go undiagnosed until they progress into greater severity. This exploratory study sought to (1) determine which scale items in the self-perceptual Evaluation of Ability to Sing Easily (EASE) are associated with instrumental voice measures, and (2) construct as proof-of-concept an instrumental index related to singers’ perceptions of their vocal function and health status. Eighteen classical singers were acoustically recorded in a controlled environment singing an /a/ vowel using soft phonation. Aerodynamic data were collected during a softly sung /papapapapapapa/ task with the KayPENTAX Phonatory Aerodynamic System. Using multi and univariate linear regression techniques, CPPS, vibrato jitter, vibrato shimmer, and an efficiency ratio (SPL/P_Sub) were included in a significant model (p < 0.001) explaining 62.4% of variance in participants’ composite scores of three scale items related to vocal fatigue. The instrumental index showed a significant association (p = 0.001) with the EASE vocal fatigue subscale overall. Findings illustrate that an aeroacoustic instrumental index may be useful for monitoring functional changes in the singing voice as part of a multidimensional diagnostic approach to preventative and rehabilitative voice healthcare for professional singing-voice users. Full article

This study examined how second language (L2) speakers’ individual differences in music perception abilities, singing abilities and phonetic aptitude relate to their L2 phonological awareness. To measure participants’ L2 phonological awareness, we used an accent faking paradigm, where participants were asked to speak in their native language (German) while imitating a strong L2 accent (English). We measured their musical abilities with the AMMA test and their singing abilities with two singing tasks and a self-report questionnaire. Their phonetic aptitude was assessed with a combination of phonological short-term memory tasks (forward and backward digit span tasks), and language perception and production tasks, in which participants needed to process and imitate sounds from unfamiliar languages. A regression analysis revealed that singing abilities and phonetic aptitude could predict participants’ English faking abilities. This suggests that being able to sing could help learners produce and memorise highly accurate L2 sounds, although their performance could also partly be explained by innate learning capacities such as phonetic aptitude. This study also proposes a new combination of tests to obtain a well-rounded assessment of individual differences in phonetic aptitude. Full article

Previous research suggests that musical ability is associated with language processing and foreign language pronunciation. Whether musical ability is associated with the ability to generate intelligible unfamiliar utterances has not been investigated. Furthermore, how unfamiliar languages are perceived has rarely been related to musical ability. We tested 80 healthy adults, with a mean age of 34.05 and a combination of 41 women and 39 men. We used batteries of perceptual and generational music and language measures to assess foreign language intelligibility and musical capacity. Regression analysis revealed that five measures explained the variance in the intelligibility of unfamiliar foreign utterances. These were short-term memory capacity, melodic singing ability, speech perception ability, and how melodic and memorable the utterances sounded to the participants. Correlational analyses revealed that musical aptitude measures are related to melodic perception and how memorable unfamiliar utterances sound, whereas singing aptitude is related to the perceived difficulty level of the language material. These findings provide novel evidence of the link between musical and speech abilities. In particular, intelligibility measures are associated with singing aptitude and how melodic languages appear to be. As impressions on how foreign languages are perceived are also related to musical capacities, perceptual language parameters address a new perspective that facilitates the understanding of the link between music and language in general. Full article

Vocal identity processing depends on the ability to tell apart two instances of different speakers whilst also being able to tell together two instances of the same speaker. Whilst previous research has examined these voice processing capabilities under relatively common listening conditions, it has not yet tested the limits of these capabilities. Here, two studies are presented that employ challenging listening tasks to determine just how good we are at these voice processing tasks. In Experiment 1, 54 university students were asked to distinguish between very similar sounding, yet different speakers (celebrity targets and their impersonators). Participants completed a ‘Same/Different’ task and a ‘Which is the Celebrity?’ task to pairs of speakers, and a ‘Real or Not?’ task to individual speakers. In Experiment 2, a separate group of 40 university students was asked to pair very different sounding instances of the same speakers (speaking and singing). Participants were presented with an array of voice clips and completed a ‘Pairs Task’ as a variant of the more traditional voice sorting task. The results of Experiment 1 suggested that significantly more mistakes were made when distinguishing celebrity targets from their impersonators than when distinguishing the same targets from control voices. Nevertheless, listeners were significantly better than chance in all three tasks despite the challenge. Similarly, the results of Experiment 2 suggested that it was significantly more difficult to pair singing and speaking clips than to pair two speaking clips, particularly when the speakers were unfamiliar. Again, however, the performance was significantly above zero, and was again better than chance in a cautious comparison. Taken together, the results suggest that vocal identity processing is a highly adaptable task, assisted by familiarity with the speaker. However, the fact that performance remained above chance in all tasks suggests that we had not reached the limit of our listeners’ capability, despite the considerable listening challenges introduced. We conclude that voice processing is far better than previous research might have presumed. Full article

(1) Background: Preterm infants spend their first weeks of life in the hospital partially separated from their parents and subjected to frequent potentially painful clinical procedures. Previous research has found that early vocal contact reduces infant pain perception while simultaneously increasing oxytocin (OXT) levels. The current study aims to assess the effect of maternal singing and speaking on mothers. (2) Methods: During a painful procedure over two days, twenty preterm infants were randomly exposed to their mother’s live voice (speaking or singing). Maternal OXT levels were measured twice: before and after singing, as well as before and after speaking. The anxiety and resilience responses of mothers were studied before and after the two-day interventions, regardless of the speaking/singing condition. OXT levels in mothers increased in response to both singing and speech. Concurrently, anxiety levels decreased, but no significant effects on maternal resilience were found. (3) Conclusions: OXT could be identified as a key mechanism for anxiety regulation in parents, even in sensitive care situations, such as when their infant is in pain. Active involvement of parents in the care of their preterm infants can have a positive effect on their anxiety as well as potential benefits to their sensitivity and care abilities through OXT. Full article

Birds may alter song structure in response to territorial challenges to convey information about aggressive intent or fighting ability. Professional and amateur ornithologists upload daily many birdsong recordings into acoustic data repositories, usually scoring whether songs were recorded in response to a conspecific playback or produced spontaneously. We analyzed recordings from these repositories to evaluate if song traits of Rufous-browed Peppershrikes (Cyclarhis gujanensis) vary between playback-elicited songs and spontaneous songs. For each recording after playback, we chose one spatially closer spontaneous recording to avoid geographic bias. Birds recorded after playback produced slightly longer songs than birds that were singing spontaneously. This result was accounted for by increases in the amount of sound and silence within a song after the playback instead of changes in the mean number or duration of elements. Playback did not alter song frequency parameters (bandwidth, minimum, mean, and maximum frequencies) or song rate. These results indicate that song duration might mediate aggressive interactions in Rufous-browed Peppershrikes. Even considering limitations such as unknown playback stimulus identity and possible pseudoreplication, acoustic data repositories give a unique yet unexplored opportunity to gather insights into the evolution of song flexibility during aggressive encounters. Full article